LEADER 03323nam 2200481 450 001 9910686788403321 005 20230731000300.0 010 $a9783031243233$b(electronic bk.) 010 $z9783031243226 024 7 $a10.1007/978-3-031-24323-3 035 $a(MiAaPQ)EBC7233709 035 $a(Au-PeEL)EBL7233709 035 $a(OCoLC)1376934127 035 $a(DE-He213)978-3-031-24323-3 035 $a(PPN)269660062 035 $a(EXLCZ)9926388129100041 100 $a20230731d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSpray drying of vaccines $efrom laboratory research to industrial applications /$fCordin Arpagaus 205 $aFirst edition 2023. 210 1$aCham, Switzerland :$cSpringer Nature Switzerland AG,$d[2023] 210 4$dİ2023 215 $a1 online resource (610 pages) $cillustrations 311 08$aPrint version: Arpagaus, Cordin Spray Drying of Vaccines Cham : Springer International Publishing AG,c2023 9783031243226 320 $aIncludes bibliographical references. 327 $aChapter 1 A short introduction to vaccines -- Chapter 2 Thermostability of vaccines -- Chapter 3 Drying technologies for vaccines -- Chapter 4 Aseptic spray drying technology -- Chapter 5 Design of experiment studies and scale-up -- Chapter 6 Applications of spray dried vaccines.-Chapter 7 Conclusions and future perspectives of spray-dried vaccines. 330 $aThis book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry. 606 $aSpray drying 606 $aVaccines$xBiotechnology 615 0$aSpray drying. 615 0$aVaccines$xBiotechnology. 676 $a660.28426 700 $aArpagaus$b Cordin$01349776 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910686788403321 996 $aSpray Drying of Vaccines$93087599 997 $aUNINA