LEADER 06557nam 22006495 450 001 9910686773403321 005 20251008140644.0 010 $a9783031215476$b(electronic bk.) 010 $z9783031215469 024 7 $a10.1007/978-3-031-21547-6 035 $a(MiAaPQ)EBC7222565 035 $a(Au-PeEL)EBL7222565 035 $a(OCoLC)1374423056 035 $a(DE-He213)978-3-031-21547-6 035 $a(PPN)269093192 035 $a(CKB)26388222300041 035 $a(EXLCZ)9926388222300041 100 $a20230329d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCholesterol and PI(4,5)P2 in Vital Biological Functions $eFrom Coexistence to Crosstalk /$fedited by Avia Rosenhouse- Dantsker 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (438 pages) 225 1 $aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1422 311 08$aPrint version: Dantsker, Avia Rosenhouse- Cholesterol and PI(4,5)P2 in Vital Biological Functions Cham : Springer International Publishing AG,c2023 9783031215469 320 $aIncludes bibliographical references and index. 327 $aPreface -- 1. Mutual influence of cholesterol and PI(4,5)P2 on their levels -- Chapter 1. Mechanism of the regulation of plasma cholesterol levels by PI(4,5)P2 -- Chapter 2. Effect of cholesterol depletion on ciliary PI(4,5)P2 levels -- Chapter 3. Impact of cholesterol on PI(4,5)P2 levels in the brain -- Chapter 4. Alterations in PIP2 levels in the intracellular cholesterol trafficking disorder NPC1 -- Chapter 5. Targeting cholesterol release and PI(4,5)P2 redistribution by the oral drug Miltefosine -- 2. Cross-talk between cholesterol and PI(4,5)P2 as a factor affecting protein function -- A. Plasma membrane ion channels -- Chapter 6. From cross-talk to synergism: the combined effect of cholesterol and PI(4,5)P2 on inwardly rectifying potassium channels -- Chapter 7. Link between lysosomal cholesterol and PI(4,5)P2 in the regulation of the voltage gated KCNQ2/3 potassium channel -- Chapter 8. Cholesterol and PI(4,5)P2 binding to a ciliary membrane transient receptor potential channel -- Chapter 9. Regulation of ell by cholesterol and PI(4,5)P2 -- Chapter 10. Cholesterol stimulates the epithelial sodium channel in a PI(4,5)P2-dependent manner -- Chapter 11. Roles of cholesterol and PI(4,5)P2 in store operated calcium entry -- Chapter 12. Roles of cholesterol and PI(4,5)P2 levels in the modulation of the calcium activated chloride channel TMEM16A -- B. Lipid transport proteins--Chapter 13. PI(4,5)P2 facilitates ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction -- Chapter 14. Role of PI(4,5)P2 binding in ORP2-mediated cholesterol distribution -- Chapter 15. PI(4,5)P2-dependent transport of cholesterol from lysosomes to peroxisomes at lysosomeperoxisome contact sites -- 3. Cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement -- Chapter 16. The insertion of the N-terminal domain of Gasdermin-D is increased byPI(4,5)P2 and decreased by cholesterol -- Chapter 17. Cholesterol promotes the cooperative interaction of formins with PI(4,5)P2 to initiate actin nucleation -- Chapter 18. Cooperation between cholesterol and PI(4,5)P2 in the regulation of Engrailed-2 homeoprotein intercellular trafficking -- Chapter 19. Cholesterol and PI(4,5)P2 as a membrane nanoplatform for HIV assembly -- Chapter 20. Role of Cholesterol and PI(4,5)P2 in the localization of the HIV-1 structural polyprotein Gag to the plasma membrane. 330 $aCholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major regulators of protein function. Studies on these important lipids have traditionally focused on the effect of each lipid individually. Accumulating evidence indicates, however, that these lipids may cross-regulate each other?s levels. Furthermore, it is becoming evident that cholesterol and PI(4,5)P2 can act together to modulate protein function and biological processes. This book provides an overview of cellular functions and molecular mechanisms in which cholesterol and PI(4,5)P2 functions extend from parallel existence to crosstalk. It includes four sections. The first section introduces the reader to cholesterol and PI(4,5)P2. The second section demonstrates the mutual influence of these two critical lipids on their levels. The third section, divided into two parts, describes the co-modulation of protein function by cholesterol and PI(4,5)P2. The first part focuses on ion channels and the second - on lipid transfer proteins. The fourth section highlights other cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement. Collectively, the book portrays the emerging relationship between cholesterol and PI(4,5)P2 in a broad array of biological systems and processes. The book will be of interest to a wide audience of research scientists with an interest in the biophysical properties of lipids and the physiological consequences of their presence in biological systems, as well as graduate students, postdoctoral trainees, basic and clinical researchers, and pharmaceutical scientists. Specifically, the content will be relevant to researchers in the fields of biochemistry, molecular biophysics, pharmacology, neurobiology, cardiovascular biology, among others. 410 0$aAdvances in Experimental Medicine and Biology,$x2214-8019 ;$v1422 606 $aPhysical biochemistry 606 $aLipids 606 $aBiochemistry 606 $aProteins 606 $aBiophysical Chemistry 606 $aLipidology 606 $aBiochemistry 606 $aProteins 615 0$aPhysical biochemistry. 615 0$aLipids. 615 0$aBiochemistry. 615 0$aProteins. 615 14$aBiophysical Chemistry. 615 24$aLipidology. 615 24$aBiochemistry. 615 24$aProteins. 676 $a405 702 $aRosenhouse-Dantsker$b Avia 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910686773403321 996 $aCholesterol and PI(4,5)P2 in Vital Biological Functions$93087705 997 $aUNINA