LEADER 03784nam 2200637 450 001 9910686476203321 005 20230824003845.0 010 $a3-031-22802-2 024 7 $a10.1007/978-3-031-22802-5 035 $a(CKB)5590000001037692 035 $a(DE-He213)978-3-031-22802-5 035 $a(MiAaPQ)EBC7236621 035 $a(Au-PeEL)EBL7236621 035 $a(PPN)269656650 035 $a(EXLCZ)995590000001037692 100 $a20230731d2023 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEngineering and physical approaches to cancer /$fIan Y. Wong and Michelle R. Dawson, editors 205 $aFirst edition 2023. 210 1$aCham, Switzerland :$cSpringer Nature Switzerland AG,$d[2023] 210 4$dİ2023 215 $a1 online resource (VIII, 331 pages, 60 illustrations, 57 illustrations in color) $cillustrations 225 1 $aCurrent Cancer Research,$x2199-2592 311 $a3-031-22801-4 320 $aIncludes bibliographical references and index. 327 $aChapter 1. EMT -- Chapter 2. Nuclear/Chromatin Mechanics -- Chapter 3. Cell level mechanical changes -- Chapter 4. Physical aspects related to metabolism -- Chapter 5. Mechanical tropism / Physical aspects of seed and soil -- Chapter 6. Tumor microenvironment interactions -- Chapter 7. Extracellular Matrix -- Chapter 8. Physical Assays Focused on Tumor Heterogeneity -- Chapter 9. Ecology / evolution of the tumor microenvironment -- Chapter 10. Spatial transcriptomics / proteomics in the Human Tumor Atlas. 330 $aEngineering and Physical Approaches to Cancer addresses the newest research at this interface between cancer biology and the physical sciences. Several chapters address the mechanobiology of collective and individual cell migration, including experimental, theoretical, and computational perspectives. Other chapters consider the crosstalk of biological, chemical, and physical cues in the tumor microenvironment, including the role of senescence, polyploid giant cells, TGF-beta, metabolism, and immune cells. Further, chapters focus on circulating tumor cells and metastatic colonization, highlighting both bioengineered models as well as diagnostic technologies. Further, this book features the work of emerging and diverse investigators in this field, who have already made impressive cross-disciplinary scientific contributions. This book is designed for a general audience, particularly researchers conversant in cancer biology but less familiar with engineering (and vice-versa). Thus, we envision that this book will be suitable for faculty, postdoctoral fellows, and advanced graduate students across medicine, biological sciences, and engineering. We also anticipate this book will be of interest to medical professionals and trainees, as well as researchers in the pharmaceutical and biomedical device industry. 410 0$aCurrent Cancer Research,$x2199-2592 606 $aBiomechanics 606 $aCancer$xImaging 606 $aCancer$xTreatment 606 $aBiomechanical Phenomena 606 $aTumor Microenvironment 606 $aExtracellular Matrix 606 $aNeoplasms 615 0$aBiomechanics. 615 0$aCancer$xImaging. 615 0$aCancer$xTreatment. 615 2$aBiomechanical Phenomena. 615 2$aTumor Microenvironment. 615 2$aExtracellular Matrix. 615 2$aNeoplasms. 676 $a612.76 702 $aWong$b Ian Y. 702 $aDawson$b Michelle R. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910686476203321 996 $aEngineering and Physical Approaches to Cancer$93089332 997 $aUNINA