LEADER 02429nam 2200373 450 001 9910683393703321 005 20230703202421.0 010 $a3-0365-6349-0 035 $a(CKB)5700000000354292 035 $a(NjHacI)995700000000354292 035 $a(EXLCZ)995700000000354292 100 $a20230703d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aOsteoporosis and Related Bone Metabolic Disease /$fedited by Heinrich Resch 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2023. 215 $a1 online resource (164 pages) 311 $a3-0365-6348-2 330 $aMany heterogeneous causes (e.g., metabolic, inflammatory, autoimmune, vascular, and renal diseases, and even drugs), collectively grouped as secondary causes of osteoporosis, may lead to bone loss or damage to architecture through a number of mechanisms. Although these secondary causes of osteoporosis are the most frequently observed causes of unexpected bone loss, they can only be diagnosed via a high degree of suspicion and clinical experience and by performing the appropriate investigations. In inflammatory disorders such as rheumatoid arthritis or chronic inflammatory bowel diseases, as well as vascular diseases, T-cell activation, and consequently pro-inflammatory cascades, trigger the increased expression of T-cell-derived RANKL. In addition, a new biomarker signature of bone-related miRNAs is promising in certain clinical features. Glucocorticoids, often used to control disease activity, decrease the number and function of osteoblasts and inhibit OPG expression. The ubiquitous occurrence of disease-related secondary changes in bone metabolism implies that numerous medical disciplines need to interact. Screening for secondary causes of osteoporosis and the search for new modes of action should present a substantial aspect of osteoporosis manageme. 606 $aBones$xMetabolism$xDisorders 606 $aOsteoporosis$xGenetic aspects 615 0$aBones$xMetabolism$xDisorders. 615 0$aOsteoporosis$xGenetic aspects. 676 $a616.7/16042 702 $aResch$b Heinrich 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910683393703321 996 $aOsteoporosis and Related Bone Metabolic Disease$93085044 997 $aUNINA