LEADER 01763nam 2200385 n 450 001 996390459703316 005 20200824120755.0 035 $a(CKB)4940000000102228 035 $a(EEBO)2248579745 035 $a(UnM)99841549e 035 $a(UnM)99841549 035 $a(EXLCZ)994940000000102228 100 $a19910408d1608 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 00$aGreenes carde of fancie$b[electronic resource] $eWherein the folly of those carpet knights is deciphered, which guiding their course by the compass of Cupid, either dash their ship against most dangerous rocks, or else attaine the haven with pain and perill. Wherein also is described in the person of Gwydonius a cruell combate between nature and necessitie. By Robert Green, Master of Art, in Cambridge 210 $aAt London $cPrinted by H[umphrey] L[ownes] for Mathewe Lownes, and are to be solde at his shop in Paules-churchyard$d1608 215 $a[152] p 300 $aPrinter's name from STC. 300 $aSignatures: A-T?. 300 $aIncludes Louise Labe?'s "The debate betweene follie and loue, translated out of French [from 'Le debat de folie et d'amour'] by Robert Greene", beginning on K3. 300 $aRunning title reads: The carde of fancie. 300 $aOriginally published in 1584 as: Gwydonius. 300 $aReproduction of the original in the Henry E. Huntington Library and Art Gallery. 330 $aeebo-0113 700 $aGreene$b Robert$f1558?-1592.$061817 701 $aLabe?$b Louise$f1526?-1566.$0436669 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996390459703316 996 $aGreenes Carde of fancie$92408052 997 $aUNISA LEADER 02839nam 2200385 450 001 9910683381003321 005 20230703073822.0 010 $a3-0365-6823-9 035 $a(CKB)5700000000354420 035 $a(NjHacI)995700000000354420 035 $a(EXLCZ)995700000000354420 100 $a20230703d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiological activities of ribosome-inactivating proteins /$fLuci?a Citores, Jose? M. Ferreras, editors 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d[2023] 215 $a1 online resource (196 pages) 311 $a3-0365-6822-0 330 $aRibosome-inactivating proteins (RIPs) are rRNA N-glycosylases isolated mainly from plants that catalyze the hydrolysis of the N-glycosidic bond of a specific adenosine in the sarcin-ricin loop (SRL) of the major ribosomal RNA. Because the SRL is crucial for anchoring translation elongation factors, RIPs cause inactivation of ribosomes. They have been classified into two types based on the presence (type 2 RIPs) or absence (type 1 RIPs) of a lectin chain that can turn type 2 RIPs into potent toxins, such as ricin or abrin. The biological role of these proteins is unknown, but they are thought to be a defense mechanism of some plants against pathogens and predators. Because of their enzymatic action, RIPs show several biological activities, among which antiviral, antifungal and antiproliferative activities stand out. The most promising application of RIPs is their use as a component of immunotoxins, in which RIPs are linked to antibodies that mediate their binding and internalization by malignant cells. In agriculture, RIPs have been shown to increase resistance against viruses, fungi and insects in transgenic plants. The studies collected in this book provide the reader with an overview of the most current and interesting lines of research in the field of RIPs and their applications in medicine and agriculture. Thus, the reprint includes the isolation and biological properties of some new RIPs, both type 1 and type 2, the mechanisms of toxicity of previously described RIPs and two extensive reviews, one on the antiviral activity of RIPs and the other on the strategies used to improve their pharmacological properties. 606 $aRibosomes$xResearch$vLaboratory manuals 606 $aProteins$xSynthesis 615 0$aRibosomes$xResearch 615 0$aProteins$xSynthesis. 676 $a574.8734 702 $aCitores$b Luci?a 702 $aFerreras$b Jose? M. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910683381003321 996 $aBiological Activities of Ribosome-Inactivating Proteins$93086631 997 $aUNINA