LEADER 03325nam 22005295 450 001 9910483196003321 005 20200705023456.0 010 $a3-540-89891-3 024 7 $a10.1007/978-3-540-89891-7 035 $a(CKB)2670000000062028 035 $a(DE-He213)978-3-540-89891-7 035 $a(SSID)ssj0000476077 035 $a(PQKBManifestationID)11913333 035 $a(PQKBTitleCode)TC0000476077 035 $a(PQKBWorkID)10479325 035 $a(PQKB)10368846 035 $a(MiAaPQ)EBC3066280 035 $a(PPN)149902336 035 $a(EXLCZ)992670000000062028 100 $a20101224d2011 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDrug Discovery and Evaluation: Methods in Clinical Pharmacology$b[electronic resource] /$fedited by H.Gerhard Vogel, Jochen Maas, Alexander Gebauer 205 $a1st ed. 2011. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2011. 215 $a1 online resource (XII, 564p. 138 illus.. eReference.) 300 $a"With 153 figures and 95 tables." 311 $a3-540-89892-1 311 $a3-540-89890-5 320 $aIncludes bibliographical references and index. 327 $asection A. Introduction -- section B. Clinical pharmacokinetics -- section C. Human studies in clinical pharmacology -- section D. Regulations. 330 $aDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume ?Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: ?Methods in Clinical Pharmacology". 606 $aPharmacology 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 615 0$aPharmacology. 615 14$aPharmacology/Toxicology. 676 $a615 702 $aVogel$b H.Gerhard$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMaas$b Jochen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGebauer$b Alexander$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910483196003321 996 $aDrug Discovery and Evaluation: Methods in Clinical Pharmacology$92513355 997 $aUNINA LEADER 01568nam 2200397 450 001 9910683378503321 005 20230627070824.0 010 $a3-0365-6834-4 024 7 $a10.3390/books978-3-0365-6834-8 035 $a(CKB)5700000000354446 035 $a(NjHacI)995700000000354446 035 $a(EXLCZ)995700000000354446 100 $a20230627d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSmart Devices and Systems for Vibration Sensing and Energy Harvesting /$fedted by Kai Tao, Yunjia Li 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2023. 215 $a1 online resource (166 pages) 311 $a3-0365-6835-2 330 $aThis reprint focuses on state-of-the-art vibration sensing and energy harvesting technologies. The 11 chapters can be divided into three aspects: (i) new materials for vibration energy harvesting applications, (ii) design and fabrication of vibration energy harvesters (VEHs), and (iii) system-level integration and testing of VEHs. 606 $aSmart materials$vCongresses 606 $aSmart structures$vCongresses 615 0$aSmart materials 615 0$aSmart structures 676 $a620.11 702 $aTao$b Kai 702 $aLi$b Yunjia 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910683378503321 996 $aSmart Devices and Systems for Vibration Sensing and Energy Harvesting$93085548 997 $aUNINA