LEADER 02151nam 2200361 450 001 9910683366003321 005 20230703095537.0 010 $a3-0365-6897-2 035 $a(CKB)5700000000354572 035 $a(NjHacI)995700000000354572 035 $a(EXLCZ)995700000000354572 100 $a20230703d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aModel-Informed Precision Dosing /$fedited by Jona?s Samuel Pe?rez-Blanco, Jose? Marti?nez Lanao 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2023. 215 $a1 online resource (320 pages) 311 $a3-0365-6896-4 330 $aModel-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs. 606 $aDrugs$xDosage 615 0$aDrugs$xDosage. 676 $a615.14 702 $aPe?rez-Blanco$b Jona?s Samuel 702 $aLanao$b Jose? Marti?nez 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910683366003321 996 $aModel-Informed Precision Dosing$93086503 997 $aUNINA LEADER 05554nam 2200697Ia 450 001 9910784652103321 005 20200520144314.0 010 $a1-280-64144-4 010 $a9786610641444 010 $a0-08-046224-3 035 $a(CKB)1000000000364099 035 $a(EBL)270372 035 $a(OCoLC)476003664 035 $a(SSID)ssj0000182543 035 $a(PQKBManifestationID)11178051 035 $a(PQKBTitleCode)TC0000182543 035 $a(PQKBWorkID)10172724 035 $a(PQKB)10698508 035 $a(MiAaPQ)EBC270372 035 $a(Au-PeEL)EBL270372 035 $a(CaPaEBR)ebr10138355 035 $a(CaONFJC)MIL64144 035 $a(OCoLC)162131351 035 $a(PPN)131230573 035 $a(EXLCZ)991000000000364099 100 $a20060609d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aIntroduction to electrophysiological methods and instrumentation$b[electronic resource] /$fFranklin Bretschneider, Jan R. de Weille 205 $a1st ed. 210 $aAmsterdam $cElsevier/ Academic Press$dc2006 215 $a1 online resource (267 p.) 300 $aDescription based upon print version of record. 311 $a0-12-370588-6 320 $aIncludes bibliographical references and index. 327 $aFront cover; Title page; Copyright page; Table of contents; Preface; 1 Electricity; Electrical Quantities; Electric Charge, Current and Potential; Resistance; Capacitance; Magnetism; Self-Inductance; Direct and Alternating Current; Frequency; Reactance; Current and Voltage Sources; Components, Unwanted Properties; Unwanted Properties, Impedance; Cables; Circuits, Schematics, Kirchoff's Laws; Composition of Similar Components: Attenuators; Practical Voltage Sources and Current Sources; Voltage and Current Measurement; Composition of Unequal Components: Filters; Integration and Differentiation 327 $aLC Filters2 Electronics; Active Elements; Vacuum Tubes and Semiconductors; Semiconductor Devices; Diodes and Transistors; Other Semiconductor Types; Amplifiers, Gain, Decibels and Saturation; Gain; Bandwidth; Input and Output Impedances; Maximum Signal Strength, Distortion; Noise, Hum Interference and Grounding; Differential Amplifiers, Block Diagrams; Operational Amplifiers, Feedback; Electronic Filters; Electrophysiological Preamplifiers; Amplifier for Extracellular Recording; Amplifier for Intracellular Recording; Patch-Clamp Amplifier; Two-Electrode Voltage-Clamp Amplifier 327 $aMeasurement of Membrane Capacitance in Voltage-ClampRecording of Secretory Events; Power Supplies and Signal Sources; Electronic Voltmeters; Electrometers; The Cathode Ray Oscilloscope; LCD Screen Oscilloscopes; Important Properties of Oscilloscopes; Digital Electronics, Logic; A/D and D/A Conversions; Computers; 3 Electrochemistry; Introduction, Properties of Electrolytes; Electrolytes; The Metal/Electrolyte Interface; Capacitance of Polarized Electrodes; Faradaic Processes; Practical Electrodes; Electrochemical Cells, Measuring Electrodes; The Silver/Silver Chloride Electrode 327 $aNon-Faradaic ProcessesElectrokinetic Processes; Liquid Junction Potentials; Membrane Potentials; Derivation of the Equilibrium Potential; The Reversal Potential; Ion Selectivity; Electrodes Sensitive to pH and Other Ions; Electrodes: Practical Aspects; The Glass Micropipette; Patch Electrodes; The Semi-Permeable Patch; Ground Electrodes; Volume Conduction: Electric Fields in Electrolyte Solutions; Homogeneous Electric Field; Monopole Field; Dipole Field; 4 Signal Analysis; Introduction; Analysis of Analogue Potentials; Systems Analysis; Convolution; The Laplace Transform 327 $aThe Fourier TransformOdd and Even Functions; Linearity; Analogue-to-Digital and Digital-to-Analogue Conversions; Signal Windowing; Digital Signal Processing; Signal Averaging; Autocorrelation; Crosscorrelation; The Discrete Fourier Transform; The Detection of Signals of Known Shape; Digital Filters; Fourier Filters and Non-Causal Filters; Non-Linear Systems Analysis; The Formal Method: Wiener Kernel Analysis; The Informal Method: Output Shape Analysis; The Importance of Non-Linearity; Analysis of Action Potential Signals; Population Spike and Gross Activity; Recording from the Skin Surface 327 $aThe Electrocardiogram 330 $aIntroduction to Electrophysiological Methods and Instrumentation covers all topics of interest to electrophysiologists, neuroscientists and neurophysiologists, from the reliable penetration of cells, the behaviour and function of the equipment, to the mathematical tools available for analysing data. It discusses the pros and cons of techniques and methods used in electrophysiology and how to avoid their pitfalls.Particularly in an era where high quality off-the-shelf solutions are readily available, it is important for the electrophysiologist to understand how his or her equipme 606 $aElectrophysiology$xEquipment and supplies 606 $aElectronics 615 0$aElectrophysiology$xEquipment and supplies. 615 0$aElectronics. 676 $a612.01427 676 $a612.813 676 $a616.807547 700 $aBretschneider$b Franklin$f1947-$01497136 701 $aDe Weille$b Jan R$0140939 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910784652103321 996 $aIntroduction to electrophysiological methods and instrumentation$93722186 997 $aUNINA