LEADER 04265nam 2200493 450 001 9910682600603321 005 20230526173550.0 010 $a3-031-23781-1 024 7 $a10.1007/978-3-031-23781-2 035 $a(MiAaPQ)EBC7212669 035 $a(Au-PeEL)EBL7212669 035 $a(CKB)26257595200041 035 $a(DE-He213)978-3-031-23781-2 035 $a(PPN)269094709 035 $a(EXLCZ)9926257595200041 100 $a20230526d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIntegrins in Health and Disease $eKey Effectors of Cell-Matrix and Cell-Cell Interactions /$fDonald Gullberg and Johannes A. Eble, editors 205 $aFirst edition. 210 1$aCham, Switzerland :$cSpringer Nature Switzerland AG,$d[2023] 210 4$dİ2023 215 $a1 online resource (473 pages) 225 1 $aBiology of Extracellular Matrix Series ;$vVolume 13 311 08$aPrint version: Gullberg, Donald Integrins in Health and Disease Cham : Springer International Publishing AG,c2023 9783031237805 320 $aIncludes bibliographical references. 327 $aPart 1: Knockouts and animal models -- Integrins ?1?1 and ?2?1 ? The generalist collagen receptors -- Roles for Integrin ?3?1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin ?8 and its ligand nephronectin in health and disease -- ?v integrin-dependent TGF? activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- ?4 integrins in immune homeostasis and disease -- ?2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin ?M?2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens. 330 $aIntegrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find ?Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions? authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology. 410 0$aBiology of extracellular matrix ;$vVolume 13. 606 $aIntegrins 615 0$aIntegrins. 676 $a572.68 702 $aGullberg$b Donald 702 $aEble$b Johannes A. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910682600603321 996 $aIntegrins in Health and Disease$93074386 997 $aUNINA