LEADER 04559nam 2200481 450 001 9910682583903321 005 20230526173555.0 010 $a9783031217760$b(electronic bk.) 010 $z9783031217753 024 7 $a10.1007/978-3-031-21776-0 035 $a(MiAaPQ)EBC7212681 035 $a(Au-PeEL)EBL7212681 035 $a(CKB)26257604200041 035 $a(DE-He213)978-3-031-21776-0 035 $a(PPN)269098941 035 $a(EXLCZ)9926257604200041 100 $a20230526d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDamage-Associated Molecular Patterns in Human Diseases$hVolume 3$iAntigen-Related Disorders /$fWalter Gottlieb Land 205 $aFirst edition. 210 1$aCham, Switzerland :$cSpringer Nature Switzerland AG,$d[2023] 210 4$dİ2023 215 $a1 online resource (708 pages) 311 08$aPrint version: Land, Walter Gottlieb Damage-Associated Molecular Patterns in Human Diseases Cham : Springer International Publishing AG,c2023 9783031217753 320 $aIncludes bibliographical references. 327 $aPreface -- Foreword -- Acknowledgments -- Abbreviations -- Part I Prologue 1 Perspectives of the Danger/Injury Model of Immunology as Applied to Antigen-Related Human Disorders -- Part II Infections 2 Infectious Agents: From the Red Queen Paradigm to Some of Their Genuine Traits -- 3 Virulence of Pathogens and the Counteracting Responses of the Host -- 4 The DAMP-Driven Host Immune Defense Program Against Pathogens -- 5 The Pathogenetic Role of DAMPs in Severe Infectious Diseases -- Part III Autoimmunity 6 Basic Trajectories in Autoimmunity -- 7 DAMPs in Systemic Autoimmune Diseases -- 8 DAMPs in Organ-Specific Autoimmune Diseases -- Part IV Transplants and Cancer 9 The Undesirable and DesirableFunctions of DAMPs in Transplant and Tumor Rejection -- Part V Epilogue 10 Approaching the DAMPome: Evolution in Medicine? 330 $aThis book is a continuation of the topic of ?DAMPs in Human Diseases?, the basics of which were described in a first volume, and details of their role in polytrauma, solid organ injuries, atherosclerosis, and cerebrocardiovascular diseases in a second volume by the same author. The third volume presents our current understanding of the impact of DAMP-driven innate/adaptive immune responses on the etiopathogenesis of antigen-related disorders, focusing on infectious and autoimmune diseases (highlighting respiratory virus diseases such as COVID-19, bacterial sepsis, and malaria) and autoimmune diseases (emphasizing systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes), and briefly discussing allograft and tumor rejection. The detailed description and illustration of DAMP-triggered inflammatory pathways in the various chapters explain, for example, why it is the dysregulated emission of DAMPs - and not the virus or the bacterium per se- that is responsible for admitting COVID-19 or sepsis patients to the ICU for intensive care treatment. Also, the chapters on autoimmune diseases explain why, mechanistically, environmental factors make up a significant part of the risk in disease initiation and propagation. Our growing understanding of such deleterious pathogenetic functions of activating DAMPs and suppressing DAMPs (SAMPs) is used as a point of departure to explore how these molecules can be used as valuable diagnostic and prognostic biomarkers as well as future therapeutic targets and therapeutics. The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. 606 $aAntigen-antibody reactions 606 $aDiseases$xMolecular aspects 615 0$aAntigen-antibody reactions. 615 0$aDiseases$xMolecular aspects. 676 $a616.0792 700 $aLand$b W$g(Walter),$0909257 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910682583903321 996 $aDamage-associated molecular patterns in human diseases$92034040 997 $aUNINA