LEADER 05154nam 22006134a 450 001 9910677482003321 005 20230617000419.0 010 $a1-280-27609-6 010 $a9786610276097 010 $a0-470-01126-2 010 $a0-470-01132-7 035 $a(CKB)1000000000226364 035 $a(EBL)239033 035 $a(OCoLC)304116727 035 $a(SSID)ssj0000180164 035 $a(PQKBManifestationID)11179429 035 $a(PQKBTitleCode)TC0000180164 035 $a(PQKBWorkID)10149465 035 $a(PQKB)11467678 035 $a(MiAaPQ)EBC239033 035 $a(EXLCZ)991000000000226364 100 $a20040720d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aInsulin resistance$b[electronic resource] $einsulin action and its disturbances in disease /$feditors, Sudhesh Kumar, Stephen O'Rahilly 210 $aChichester, West Sussex, England ;$aHoboken, N.J. $cJ. Wiley$dc2005 215 $a1 online resource (617 p.) 300 $aDescription based upon print version of record. 311 $a0-470-85008-6 320 $aIncludes bibliographical references and index. 327 $aInsulin Resistance; Contents; Preface; List of Contributors; 1 The Insulin Receptor and Downstream Signalling; 1.1 Introduction; 1.2 Insulin receptor structure and function; 1.3 Insulin receptor substrates; 1.4 Downstream signalling pathways; 1.5 The basis of insulin's signalling specificity; 1.6 Conclusion; References; 2 Insulin-mediated Regulation of Glucose Metabolism; 2.1 Introduction; 2.2 Insulin as a master regulator of whole body glucose disposal; 2.3 Insulin-mediated regulation of glucose metabolic pathways 327 $a2.4 Glucose uptake into skeletal muscle - the rate-limiting step in glucose metabolismAcknowledgements; References; 3 Insulin Action on Lipid Metabolism; 3.1 Introduction: does insulin affect lipid metabolism?; 3.2 Molecular mechanisms by which insulin regulates lipid metabolism; 3.3 Insulin and lipolysis; 3.4 Insulin, lipoprotein lipase and cellular fatty acid uptake; 3.5 Co-ordinated regulation of fatty acid synthesis and ketogenesis; 3.6 Insulin and cholesterol synthesis; 3.7 Insulin effects on lipoprotein metabolism; Acknowledgement; References 327 $a4 The Effect of Insulin on Protein Metabolism4.1 Introduction; 4.2 Molecular mechanisms of insulin's effect on protein turnover; 4.3 Measurement of protein metabolism (synthesis and breakdown or turnover) in human subjects; 4.4 Whole body and regional protein turnover; Acknowledgements; References; 5 Genetically Modified Mouse Models of Insulin Resistance; 5.1 Introduction; 5.2 Genetic modification as a tool to dissect the mechanisms leading to insulin resistance; 5.3 Candidate genes involved in the mechanisms of insulin resistance; 5.4 Insulin signalling network 327 $a5.5 Factors leading to insulin resistance5.6 Defining the function of the insulin cascade molecules through global knockouts; 5.7 Double heterozygous mice as models of polygenic forms of diabetes; 5.8 Defining tissue and/or organ relevance for the maintenance of insulin sensitivity; 5.9 Genetically modified mice to study modulators of insulin sensitivity; 5.10 Lipodystrophy versus obesity, the insulin resistance paradox; 5.11 Excess of nutrients as a cause of insulin resistance; 5.12 PPARs, key mediators of nutritional-regulated gene expression and insulin sensitivity; References 327 $a6 Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes6.1 Introduction; 6.2 Measurement of insulin resistance; 6.3 Insulin-resistant states; 6.4 Conclusion and perspectives; References; 7 Central Regulation of Peripheral Glucose Metabolism; 7.1 Introduction; 7.2 Counter-regulation of hypoglycaemia - role of the CNS; 7.3 Brain regions involved in counter-regulation; 7.4 Glucosensing neurons; 7.5 Central control of peripheral organs involved in glucoregulation 327 $a7.6 Additional afferent signals to the CNS regulating peripheral glucose metabolism 330 $aDiabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects.The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycy 606 $aInsulin resistance 615 0$aInsulin resistance. 676 $a612.34 676 $a616.4/6207 676 $a616.46207 701 $aKumar$b Sudhesh$0855737 701 $aO'Rahilly$b S$g(Stephen)$01342810 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910677482003321 996 $aInsulin resistance$93066588 997 $aUNINA