LEADER 05424nam 2200685Ia 450 001 9910677468603321 005 20200520144314.0 010 $a9786611002138 010 $a9781281002136 010 $a1281002135 010 $a9780470085226 010 $a0470085223 010 $a9780470085219 010 $a0470085215 035 $a(CKB)1000000000376116 035 $a(EBL)315158 035 $a(OCoLC)630529340 035 $a(SSID)ssj0000611743 035 $a(PQKBManifestationID)11445577 035 $a(PQKBTitleCode)TC0000611743 035 $a(PQKBWorkID)10666442 035 $a(PQKB)10432027 035 $a(MiAaPQ)EBC315158 035 $a(PPN)240480511 035 $a(Perlego)2758606 035 $a(EXLCZ)991000000000376116 100 $a20050722d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug discovery and development$hVolume 2$iDrug development /$fedited by Mukund S. Chorghade 210 $aHoboken, N.J. $cWiley-Interscience$dc2007 215 $a1 online resource (401 p.) 300 $aDescription based upon print version of record. 311 08$a9780471398479 311 08$a0471398470 320 $aIncludes bibliographical references and index. 327 $aDRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Contributors; Preface; 17 Bioactive Molecules in Medicinal Plants: A Perspective on Their Therapeutic Action; 17.1 Introduction; 17.2 Evolutionary Relationships Among Plants and Humans; 17.3 Traditional Wisdom; 17.4 Unique Libraries for Plants; 17.5 Drugs and Bioactive Molecules from Plants; 17.6 Synergism in Herbal Formulations; 17.7 Interactions Between Modern Drugs and Natural Products; 17.8 Bioavailability and Bioefficacy Enhancers; 17.9 Combination Therapies in Modern Drugs; 17.10 Role of Developments in Technologies and Analytical Tools 327 $a17.10.1 Developments in Separation Technologies17.10.2 Developments in Combined Techniques and Advanced Technologies; 17.10.3 Molecular Farming and Bioengineering of Medicinal Plants; 17.10.4 High-Throughput Screening of Natural Products; 17.11 Herbal Medicine: The Best Possible Route to Health Care; References; 18 Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools; 18.1 Introduction; 18.2 Solid-Supported Reagents as Tools in Natural Product Synthesis; 18.3 Multistep Use of Supported Reagents in Natural Product Synthesis; 18.4 Conclusions 327 $aReferences19 Insulin Sensitizers: Emerging Therapeutics; 19.1 Introduction; 19.2 Therapeutic Interventions; 19.3 Discovery of Insulin Sensitizers; 19.4 Journey Toward New Drugs; 19.5 Conclusions; References; 20 Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals; 20.1 Introduction; 20.2 Criteria for Technology Readiness; 20.3 Examples of Industrially Ready Chiral Catalytic Technologies and Their Application; 20.3.1 Lipase Bioresolution: Ethyl 3-Amino-3-Phenylpropionate; 20.3.2 Aminoacylase Bioresolution of N-Acylamino Acids 327 $a20.3.3 Asymmetric Hydrogenation of Prochiral Olefins by Rhodium-DuPhos Catalysts20.3.4 Asymmetric Hydrogenation of Prochiral Ketones by Ruthenium-Biphosphine-Diamine Catalysts; 20.3.5 Asymmetric Hydroformylation with Rhodium-Phosphite Catalysts; 20.3.6 Asymmetric Allylic Substitution with Palladium-Based Catalysts; 20.4 How Industrially Ready Technology Can Deliver Commercial Advantages; 20.5 Conclusions; References; 21 Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons; 21.1 Introduction; 21.2 Asymmetric Reduction of Prochiral ?, ?-Alkynyl Ketones 327 $a21.3 Addition of Acetylenic Anion to Carbonyl Carbon21.4 Desymmetrization and Enzymatic Strategies for Chiral Propargyl Alcohol Synthesis; 21.5 ?-Elimination Strategy and Miscellaneous Approaches; 21.6 Conclusions; References; 22 Carbohydrates: From Chirons to Mimics; 22.1 Introduction; 22.2 Synthetic Strategies for C-Glycosides; 22.3 Synthetic Strategies for Carbon-Linked Disaccharides and Pseudosaccharides; References; 23 Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients; 23.1 Introduction; 23.1.1 Drug Development in the Pharmaceutical Industry 327 $a23.1.2 Challenges in Developing and Scaling Up Chemical Processes 330 $aFrom first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume re 606 $aDrug development 606 $aPharmacology 615 0$aDrug development. 615 0$aPharmacology. 676 $a615.1072 676 $a615.19 701 $aChorghade$b Mukund S$g(Mukund Shankar)$01339568 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910677468603321 996 $aDrug discovery and development$93060765 997 $aUNINA