LEADER 04411nam 2200517 450 001 9910677158003321 005 20230630002559.0 010 $a1-119-67837-4 010 $a1-119-67836-6 010 $a1-119-67827-7 010 $a9781119678274$b(adobe pdf) 010 $a9781119678373$b(epub) 010 $z9781119678281$b(cloth) 035 $a(MiAaPQ)EBC6826398 035 $a(Au-PeEL)EBL6826398 035 $a(CKB)20133956300041 035 $a(OCoLC)1289369487 035 $a(EXLCZ)9920133956300041 100 $a20220827d2022 uy 0 101 0 $aeng 135 $aurcz#---auuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiopharmaceutics $efrom fundamentals to industrial practice /$fedited by Hannah Batchelor 205 $aFirst edition. 210 1$aChichester, West Sussex, England :$cJohn Wiley & Sons,$d[2022] 210 4$dİ2022 215 $a1 online resource (319 pages) 225 1 $aAdvances in Pharmaceutical Technology 311 08$aPrint version: Batchelor, Hannah Biopharmaceutics Newark : John Wiley & Sons, Incorporated,c2021 9781119678281 320 $aIncludes bibliographical references and index. 327 $aAn introduction to biopharmaceutics / Hannah Batchelor -- Basic pharmacokinetics / Hamid A. Merchant -- Introduction to biopharmaceutics measures / Hannah Batchelor and Pavel Gershkovich --Solubility / Hannah Batchelor -- Permeability / Chris Roe and Vanessa Zann -- Dissolution / Hannah Batchelor and James Butler -- Biopharmaceutics to inform candidate drug selection and optimisation / Linette Ruston -- Biopharmaceutics tools for rational formulation design / Panagiota Zarmpi, Mark McAllister, James Butler, and Nikoletta Fotaki -- Biopharmaceutic classification system / Hannah Batchelor and Talia Flanagan -- Regulatory biopharmaceutics / Shanoo Budhdeo, Paul A. Dickinson, and Talia Flanagan -- Impact of anatomy and physiology / Francesca K. H. Gavins, Christine M. Madla, Sarah J. Trenfield, Laura E. McCoubrey, Abdul W. Basit, and Mark McAllister -- Integrating biopharmaceutics to predict oral absorption using PBPK modelling / Konstantinos Stamatopoulos --Special populations / Christine M. Madla, Francesca K. H. Gavins, Sarah J. Trenfield, and Abdul W. Basit -- Inhalation biopharmaceutics / Precious Akhuemokhan, Magda Swedrowska and Ben Forbes -- Biopharmaceutics of injectable formulations / Wang Wang Lee and Claire M. Patterson -- Biopharmaceutics of topical and transdermal formulations / Hannah Batchelor -- Impact of the microbiome on oral biopharmaceutics / Laura E. McCoubrey, Hannah Batchelor, Abdul W. Basit, Simon Gaisford, and Mine Orlu. 330 $a"This book arose as a result of this mission where the members of the focus group recognised the need to provide training for those wanting to better understand biopharmaceutics and serves as a handbook to introduce the tools used within biopharmaceutics as applied to drug development. The first six chapters cover the basics of biopharmaceutics and provide the context that underpins the later chapters. Chapters 7 and 8 specifically deal with how biopharmaceutics is integrated into product development within the pharmaceutical industry. Chapters 9 and 10 provide information on the regulatory aspects of biopharmaceutics. Chapter 11 highlights the impact of physiology and anatomy and how this can affect the rate and extent of drug absorption. Physiologically based modelling is a valuable asset in the biopharmaceutics toolkit, and this is introduced in Chapter 12. Chapter 13 provides information on a more advanced topic, the application of biopharmaceutics to special populations. Although oral administration remains the mainstay of drug therapy, it is not the exclusive route of administration, Chapters 14-16 cover alternative routes of administration. A newly emerging topic that considers the impact of the microbiome on the rate and extent of drug absorption is included as the final chapter in this book"--$cProvided by publisher. 410 0$aAdvances in pharmaceutical technology. 606 $aBiopharmaceutics 615 0$aBiopharmaceutics. 676 $a615.7 702 $aBatchelor$b Hannah 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910677158003321 996 $aBiopharmaceutics$93068963 997 $aUNINA