LEADER 02965nam 2200385 450 001 9910674398603321 005 20230625131909.0 035 $a(CKB)5400000000046276 035 $a(NjHacI)995400000000046276 035 $a(EXLCZ)995400000000046276 100 $a20230625d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNASH and Systemic Complications $eFrom Basic to Clinical Research /$fRonit Shiri-Sverdlov and Sabine Baumgartner 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2022. 215 $a1 online resource (232 pages) 311 $a3-0365-2978-0 330 $aNonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). NASH is a chronic inflammatory condition of the liver that can further progress to fibrosis and cirrhosis, which may eventually lead to liver failure and death. While we have increased our mechanistic knowledge regarding the pathogenesis of NASH within the last decade, treatment options are still limited and liver biopsies have remained the gold standard for diagnosis. To achieve major clinical breakthroughs for NASH patients, it is not sufficient to use a single animal model, since each model has specific limitations. Furthermore, we should rely more on alternative models such as organ-on-a-chip, which will enable us to explore unknown aspects of disease pathogenesis much faster and serve as clinically relevant surrogates for murine models. Another important direction for the improvement of patient health is to pay more attention to extrahepatic, organ-specific and systemic effects, which are associated with NASH. The articles in this Special Issue include an up-to-date overview of the rapidly developing technologies, novel targets for intervention and insights in the field in NASH. Additionally, these articles describe the major challenges in the field, strategies to overcome them and suggestions for future directions. To improve patient's outcome, clinicians, as well as scientists with biomedical, nutrition, physics and mathematics backgrounds, should join forces. Although challenges remain, the future of the field seems promising as these novel technologies and developments are expected to lead to progress in NASH. 517 $aNASH and Systemic Complications 606 $aClinical trials 606 $aBiomedical materials 615 0$aClinical trials. 615 0$aBiomedical materials. 676 $a610.724 700 $aShiri-Sverdlov$b Ronit$01367755 702 $aBaumgartner$b Sabine 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910674398603321 996 $aNASH and Systemic Complications$93391558 997 $aUNINA