LEADER 03347nam 2200829z- 450 001 9910674395803321 005 20231214132945.0 035 $a(CKB)5400000000042115 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/77041 035 $a(EXLCZ)995400000000042115 100 $a20202201d2021 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRole of TCTP in Cell Biological and Disease Processes 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2021 215 $a1 electronic resource (150 p.) 311 $a3-0365-2285-9 311 $a3-0365-2286-7 330 $aTranslationally controlled tumor protein (TCTP), also referred to as HRF or fortilin, is a multifunctional protein, expressed in all eukaryotic organisms from protozoa to humans. TCTP is involved in many basic biological processes, such as cell division, growth, and development. It is therefore not surprising that dysregulation of TCTP occurs in various disease processes, such as cardiovascular, allergic, and immune disorders. TCTP?s role in cancer-promoting pathways is well- documented, and the protein is considered a potential target for the design of new anti-cancer strategies. Therefore, an understanding of the core biological functions of TCTP, the mechanisms underlying its cellular regulation, and its involvement in disease processes is important. This book provides a current overview on the basic biological functions of TCTP and on its role in promoting a range of disease processes. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $aLoxosceles 610 $abrown spider 610 $aTCTP 610 $avenom 610 $atoxin 610 $aHRF 610 $aallergy 610 $amast cells 610 $abasophils 610 $aIgE 610 $aFc?RI 610 $atranslationally controlled tumor protein (TCTP) 610 $aapoptosis 610 $aconditional knockout mice 610 $adevelopment 610 $aNestin-cre 610 $aneurogenesis 610 $aneuronal progenitor cells 610 $aperinatal death 610 $aproliferation 610 $aMmi1 610 $atranslationally controlled tumor protein 610 $aautophagy 610 $areactive oxygen species 610 $arapamycin 610 $anitrogen starvation 610 $acancer 610 $aphospho-TCTP 610 $aDHA 610 $aT-DM1 610 $aHER2-positive breast cancer 610 $aTCTP (HRF 610 $afortilin) 610 $agrowth and development 610 $abiological stress reactions 610 $aregulation of protein synthesis 610 $aregulated protein degradation 610 $acardiovascular diseases 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aBommer$b Ulrich-Axel$4edt$01338462 702 $aKawakami$b Toshiaki$4edt 702 $aBommer$b Ulrich-Axel$4oth 702 $aKawakami$b Toshiaki$4oth 906 $aBOOK 912 $a9910674395803321 996 $aRole of TCTP in Cell Biological and Disease Processes$93058560 997 $aUNINA