LEADER 02259nam 2200373 450 001 9910674389103321 005 20230625023442.0 035 $a(CKB)5400000000045816 035 $a(NjHacI)995400000000045816 035 $a(EXLCZ)995400000000045816 100 $a20230625d2017 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUpdated View on an Emerging Target $eSelected Papers from the 8th International Conference on Protein Kinase CK2 /$fedited by Joachim Jose [and three others] 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2017. 210 4$dİ2017 215 $a1 online resource (xiii, 320 pages) $cillustrations 311 $a3-03842-412-9 320 $aIncludes bibliographical references. 330 $aThe 8th International Conference on Protein Kinase CK2 (www.uks.eu/ck2), organized by Matthias Montenarh and Claudia Go?tz, will be held at the Faculty of Medicine of Saarland University, in Homburg, Germany, from 6-9 September, 2016. Protein kinase CK2 is a serine/threonine kinase, which is highly conserved in evolution. Knock-out experiments have shown that this enzyme is absolutely necessary for cell viability. The enzyme is highly expressed in rapidly proliferating cells, which goes along with an elevated enzyme activity. Protein kinase CK2 is involved in a broad range of signaling pathways, regulating proliferation, differentiation, apoptosis, or senescence. Recent advances towards the characterization of the three-dimensional structure of protein kinase CK2 and its subunits will undoubtedly yield important new insights into its regulation, and the functions of CK2. Moreover, with two inhibitors of the enzyme presently in clinical phase II trials, human protein kinase CK2 has appeared as an emerging target for cancer diseases. 517 $aUpdated View on an Emerging Target 606 $aProtein kinase CK2 615 0$aProtein kinase CK2. 676 $a572.76 702 $aJose$b Joachim 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910674389103321 996 $aUpdated View on an Emerging Target$93390456 997 $aUNINA