LEADER 02898nam 2200385 450 001 9910674383003321 005 20230623221714.0 024 7 $a10.3390/books978-3-0365-2717-8 035 $a(CKB)5400000000043757 035 $a(NjHacI)995400000000043757 035 $a(EXLCZ)995400000000043757 100 $a20230623d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aArteriogenesis and therapeutic angiogenesis /$fedited by Paul Quax, Elisabeth Deindl 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2022. 215 $a1 online resource (220 pages) 311 $a3-0365-2716-8 330 $aAlthough advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions. 606 $aMedicine$xPractice 606 $aMedicine$vEarly works to 1800 615 0$aMedicine$xPractice. 615 0$aMedicine 676 $a610.8 702 $aQuax$b Paul 702 $aDeindl$b Elisabeth 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910674383003321 996 $aArteriogenesis and Therapeutic Angiogenesis$92943953 997 $aUNINA