LEADER 03389nam 2200373 450 001 9910674044303321 005 20230629164323.0 024 7 $a10.3390/books978-3-0365-2939-4 035 $a(CKB)5400000000044259 035 $a(NjHacI)995400000000044259 035 $a(EXLCZ)995400000000044259 100 $a20230629d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe Role of Complement in Cancer Immunotherapy /$fedited by Ronald P. Taylor 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2022. 215 $a1 online resource (156 pages) 311 $a3-0365-2938-1 330 $aThe dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the killing of malignant cells. Indeed, there are now numerous examples of monoclonal antibodies (mAbs) that have either been approved by the FDA or that are under active investigation that make use of complement when eliminating cancer cells. Although the direct in vitro killing of mAb-opsonized cancer cell lines by complement-dependent cytotoxicity (CDC) can be readily demonstrated, there are considerable challenges related to the translation of these findings to the clinic, and numerous strategies have been employed to maximize mAb-mediated CDC in cancer treatment. These approaches include the redesign of mAb dosing schedules; engineering the Fc regions of the mAbs to enhance complement activation; treatment with cocktails of mAbs that bind to several different sites on the targeted cells and thus that potentially synergize CDC promotion; and neutralizing the complement control proteins on malignant cells to weaken their defenses against complement. Target sites on malignant cells that have been successfully exploited for mAb-induced CDC include CD20, CD37, CD38, CD52, and Epidermal Growth Factor Receptors. MAbs specific to complement components have served as powerful analytical reagents to investigate the detailed mechanisms of CDC, and they have been employed to document complement activation by cancer cells and to examine the role of complement proteins (in particular C1q and fragments of C3 and C5) in supporting tumor growth. The use of polyclonal and mAb reagents has revealed a role for the intracellular complement system in cancer biology and strategies that focus on the interaction of complement with the tumor microenvironment, and examining the impact of the complotype on the response to immunotherapy in cancer should lead to additional mAb-based therapies. Along these lines, there is now increasing evidence that strategies that make use of mAbs or other agents to modulate the action of C3a/C5a or their respective receptors may also find use in cancer immunotherapy. 606 $aCancer$xImmunotherapy 606 $aCancer vaccines 615 0$aCancer$xImmunotherapy. 615 0$aCancer vaccines. 676 $a616.994061 702 $aTaylor$b Ronald P. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910674044303321 996 $aThe Role of Complement in Cancer Immunotherapy$93395465 997 $aUNINA