LEADER 03376nam 2200373 450 001 9910674023003321 005 20230629104757.0 035 $a(CKB)4920000000094898 035 $a(NjHacI)994920000000094898 035 $a(EXLCZ)994920000000094898 100 $a20230629d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChemical and Molecular Approach to Tumor Metastases /$fedited by Gianni Sava and Alberta Bergamo 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2018. 210 4$dİ2018 215 $a1 online resource (vii, 264 pages) $cillustrations 311 $a3-03842-895-7 320 $aIncludes bibliographical references. 330 $aMalignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is responsible for the unfavorable prognosis and of relapses even after initially successful tumor therapies. The lack of success of chemo- and immune-therapy approaches depends on many factors among which, the inadequate capacity of the anti-tumor drugs of reaching appropriate concentrations in the organs and tissues involved in the metastatic growth is a major concern. Another factor is the complexity of the metastasis biology and of their molecular behavior, evidencing a population of tumor cells with a genetic compartment different from that of the tumor of origin. The involvement of host cells and factors recruited by the metastatic cells and committed to support the metastatic growth is also an event crucial for the lack of success of the anti-tumor therapy. The knowledge of the molecular biology of metastases is mandatory to support the search for chemical agents to treat the metastatic determinants and to control of the neoplastic disease. This Special Issue on "Chemical and Molecular Approach to Tumor Metastases" will explore the impact of biology, molecular medicine and chemistry on all aspects related to tumor metastases from the biological and molecular aspects of the metastatic growth, including the relationships between the metastatic cells and the host environment, and the search for druggable determinants useful for the chemical analysis of agents selectively active against tumor metastases. With the combination of invited reviews and original papers from prominent scientists working on all aspects of molecular medicine and cancer therapy, such as, but not limited to: drug delivery, genomics, chemoprevention, drug discovery, we aim to sample recent progress in molecular and chemical aspects of therapy of malignant tumors. Clinical success studies and evidences of novel compounds are particularly welcome. 606 $aNeural transmission 615 0$aNeural transmission. 676 $a599.0188 702 $aSava$b Gianni 702 $aBergamo$b Alberta 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910674023003321 996 $aChemical and Molecular Approach to Tumor Metastases$92932975 997 $aUNINA