LEADER 03509nam 2200829z- 450 001 9910674013003321 005 20220506 035 $a(CKB)5680000000037611 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81046 035 $a(oapen)doab81046 035 $a(EXLCZ)995680000000037611 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (190 p.) 311 08$a3-0365-3946-8 311 08$a3-0365-3945-X 330 $aAntimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens. 606 $aBiology, life sciences$2bicssc 606 $aMicrobiology (non-medical)$2bicssc 606 $aResearch & information: general$2bicssc 610 $aadaptation 610 $aAliarcobacter butzleri 610 $aallostery 610 $aantibiotic resistance 610 $aantimicrobial resistance 610 $aassembly 610 $aconformational changes 610 $acystic fibrosis 610 $adominant negative effect 610 $adrug resistance 610 $adye accumulation 610 $aefflux pump 610 $aenergetic transition 610 $aevolution 610 $agram-negative bacteria 610 $ahospital acquired infections 610 $aMdtF (YhiV) 610 $amultidrug resistance 610 $amutation 610 $an/a 610 $apathogens 610 $aprevalence of efflux resistance mechanisms 610 $aprotein-protein interaction 610 $apump activation 610 $areal-time efflux 610 $aresistance 610 $aRND 610 $aRND efflux pumps 610 $aRND pump 610 $aRND-type efflux pump 610 $avirulence 615 7$aBiology, life sciences 615 7$aMicrobiology (non-medical) 615 7$aResearch & information: general 700 $aBroutin$b Isabelle$4edt$01339339 702 $aVargiu$b Attilio V$4edt 702 $aVenter$b Henrietta$4edt 702 $aPhan$b Gilles$4edt 702 $aBroutin$b Isabelle$4oth 702 $aVargiu$b Attilio V$4oth 702 $aVenter$b Henrietta$4oth 702 $aPhan$b Gilles$4oth 906 $aBOOK 912 $a9910674013003321 996 $aThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria$93060056 997 $aUNINA LEADER 03245nam 22007334a 450 001 9910143274103321 005 20250111110035.0 010 $a9786613267139 010 $a9781283267137 010 $a1283267136 010 $a9780874214918 010 $a0874214912 035 $a(CKB)1000000000344123 035 $a(EBL)287120 035 $a(OCoLC)779852234 035 $a(SSID)ssj0000458228 035 $a(PQKBManifestationID)11268380 035 $a(PQKBTitleCode)TC0000458228 035 $a(PQKBWorkID)10439286 035 $a(PQKB)10018291 035 $a(MdBmJHUP)muse16327 035 $a(Au-PeEL)EBL3442771 035 $a(CaPaEBR)ebr10328683 035 $a(OCoLC)932313523 035 $a(Au-PeEL)EBL287120 035 $a(CaONFJC)MIL326713 035 $a(MiAaPQ)EBC3442771 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/47769 035 $a(DE-B1597)716541 035 $a(DE-B1597)9780874214918 035 $a(MiAaPQ)EBC287120 035 $a(Perlego)2056116 035 $a(oapen)doab47769 035 $a(EXLCZ)991000000000344123 100 $a20030825d2003 ub 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe flowering thorn $einternational ballad studies /$fedited by Thomas A. McKean 205 $a1st ed. 210 $aLogan, Utah $cUtah State University Press$dc2003 215 $a1 online resource (395 p.) 300 $a"A project of the Kommission fur Volksdichtung and the Elphinstone Institute." 311 08$a9780874215687 311 08$a0874215684 320 $aIncludes bibliographical references and indexes. 327 $aContents; Introduction; Now She's Fairly Altered Her Meaning: Interpreting Narrative Song; Malign Forces That Can Punish and Pardon: Structure and Motif; Recapturing the Journey: Cruxes of Context, Version, and Transmission; Regions, Reprints, and Repertoires; ""Purement scientifique et archeologique"": The Mediating Collector; Acknowledgments; Notes on Contributors; General Index; Song Title Index 330 $aThe flowering thorn expresses the dual nature of the ballad: at once a distinctive expression of European tradition, but also somewhat tricky to approach from a scholarly perspective, requiring a range of disciplines to illuminate its rich composition. Most of this latter quality has to do with the very features that characterize ballads... or narrative songs. These include an appearance of fragmentation; a wide range of cultural and social referents; complex, evocative symbolic language; and variation. The notable multiformity of meaning, text and tune is mirrored in scholarsh 606 $aBallads$xHistory and criticism 606 $aFolk literature$xHistory and criticism 615 0$aBallads$xHistory and criticism. 615 0$aFolk literature$xHistory and criticism. 676 $a782.4/3 700 $aMckean$b Thomas, $4aut$4http://id.loc.gov/vocabulary/relators/aut 701 $aMcKean$b Thomas A.$f1961-$0961850 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143274103321 996 $aThe flowering thorn$92180657 997 $aUNINA