LEADER 01113nam0-22003611i-450- 001 990002104300403321 005 20160523173516.0 010 $a0080374948 035 $a000210430 035 $aFED01000210430 035 $a(Aleph)000210430FED01 035 $a000210430 100 $a20030910d1990----km-y0itay50------ba 101 0 $aeng 102 $aGB 105 $ay-------001yy 200 1 $a<>analysis of response in crop and livestock production$fby John L. Dillon, Jock R. Anderson 205 $a3. ed. 210 $aOxford$cPergamon Press$d1990 215 $aXII, 251 p.$d22 cm 610 0 $aAlimenti per animali$aProduzione$aModelli matematici 610 0 $aAlimenti per animali$aProduzione$aMetodi statistici 676 $a630.68$v19$zita 676 $a338.1$v9$zita 700 1$aDillon,$bJohn L.$0358882 701 1$aAnderson,$bJock R. 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990002104300403321 952 $a62 338.1 DIL$bDEPA 6801$fDAGEA 959 $aDAGEA 996 $aAnalysis of response in crop and livestock production$9394666 997 $aUNINA LEADER 03472nam 2200805z- 450 001 9910674013003321 005 20231214133533.0 035 $a(CKB)5680000000037611 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81046 035 $a(EXLCZ)995680000000037611 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (190 p.) 311 $a3-0365-3946-8 311 $a3-0365-3945-X 330 $aAntimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aMicrobiology (non-medical)$2bicssc 610 $aMdtF (YhiV) 610 $amultidrug resistance 610 $aRND-type efflux pump 610 $adye accumulation 610 $areal-time efflux 610 $apathogens 610 $aRND 610 $aevolution 610 $aefflux pump 610 $aadaptation 610 $aAliarcobacter butzleri 610 $aRND efflux pumps 610 $avirulence 610 $aresistance 610 $aRND pump 610 $adominant negative effect 610 $aassembly 610 $aprotein-protein interaction 610 $amutation 610 $adrug resistance 610 $acystic fibrosis 610 $aprevalence of efflux resistance mechanisms 610 $ahospital acquired infections 610 $aantibiotic resistance 610 $aallostery 610 $aantimicrobial resistance 610 $aconformational changes 610 $aenergetic transition 610 $agram-negative bacteria 610 $apump activation 615 7$aResearch & information: general 615 7$aBiology, life sciences 615 7$aMicrobiology (non-medical) 700 $aBroutin$b Isabelle$4edt$01339339 702 $aVargiu$b Attilio V$4edt 702 $aVenter$b Henrietta$4edt 702 $aPhan$b Gilles$4edt 702 $aBroutin$b Isabelle$4oth 702 $aVargiu$b Attilio V$4oth 702 $aVenter$b Henrietta$4oth 702 $aPhan$b Gilles$4oth 906 $aBOOK 912 $a9910674013003321 996 $aThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria$93060056 997 $aUNINA