LEADER 03509nam  2200829z- 450 
001 9910674013003321
005 20220506
035   $a(CKB)5680000000037611
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81046
035   $a(oapen)doab81046
035   $a(EXLCZ)995680000000037611
100   $a20202205d2022      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria
210   $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022
215   $a1 online resource (190 p.)
311 08$a3-0365-3946-8 
311 08$a3-0365-3945-X 
330   $aAntimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.
606   $aBiology, life sciences$2bicssc
606   $aMicrobiology (non-medical)$2bicssc
606   $aResearch & information: general$2bicssc
610   $aadaptation
610   $aAliarcobacter butzleri
610   $aallostery
610   $aantibiotic resistance
610   $aantimicrobial resistance
610   $aassembly
610   $aconformational changes
610   $acystic fibrosis
610   $adominant negative effect
610   $adrug resistance
610   $adye accumulation
610   $aefflux pump
610   $aenergetic transition
610   $aevolution
610   $agram-negative bacteria
610   $ahospital acquired infections
610   $aMdtF (YhiV)
610   $amultidrug resistance
610   $amutation
610   $an/a
610   $apathogens
610   $aprevalence of efflux resistance mechanisms
610   $aprotein-protein interaction
610   $apump activation
610   $areal-time efflux
610   $aresistance
610   $aRND
610   $aRND efflux pumps
610   $aRND pump
610   $aRND-type efflux pump
610   $avirulence
615  7$aBiology, life sciences
615  7$aMicrobiology (non-medical)
615  7$aResearch & information: general
700   $aBroutin$b Isabelle$4edt$01339339
702   $aVargiu$b Attilio V$4edt
702   $aVenter$b Henrietta$4edt
702   $aPhan$b Gilles$4edt
702   $aBroutin$b Isabelle$4oth
702   $aVargiu$b Attilio V$4oth
702   $aVenter$b Henrietta$4oth
702   $aPhan$b Gilles$4oth
906   $aBOOK
912   $a9910674013003321
996   $aThe Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria$93060056
997   $aUNINA