LEADER 05057nam 22015133a 450 001 9910674009603321 005 20250203235430.0 010 $a9783039210831 010 $a3039210831 024 8 $a10.3390/books978-3-03921-083-1 035 $a(CKB)4920000000094815 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61371 035 $a(ScCtBLL)8bd267cb-866f-46c6-87e7-02a7821517e4 035 $a(OCoLC)1126206907 035 $a(oapen)doab61371 035 $a(EXLCZ)994920000000094815 100 $a20250203i20192019 uu 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTRP Channels in Health and Disease$fAlexander Dietrich 210 $cMDPI - Multidisciplinary Digital Publishing Institute$d2019 210 1$aBasel, Switzerland :$cMDPI,$d2019. 215 $a1 electronic resource (266 p.) 311 08$a9783039210824 311 08$a3039210823 330 $aAlmost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for "canonical", TRPA with A for "ankyrin", TRPM with M for "melastatin", TRPML with ML for "mucolipidin", TRPP with P for "polycystin", and TRPV with V for "vanilloid". Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in "Cells" summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options. 606 $aMedicine$2bicssc 610 $atransient receptor potential channels 610 $aphotochromic ligands 610 $aelementary immunology 610 $aPurkinje cell 610 $aEPSC 610 $asubstance P 610 $achemicals 610 $aorgan toxicity 610 $alymphocytes 610 $aHSP70 610 $aphysiology 610 $abioavailable 610 $ainflammatory bowel disease 610 $aplatelets 610 $apollutants 610 $ayeast 610 $aregulatory T cells 610 $akinase 610 $aSaccharomyces cerevisiae 610 $amanganese 610 $acerebellum 610 $aTRP channel 610 $aNHERF 610 $ainflammation 610 $ananoHPLC-ESI MS/MS 610 $aTRPM7 610 $achemical probes 610 $aTRPM8 610 $adorsal column nuclei 610 $aTRPV2 610 $aTRPV3 610 $acalcitonin gene-related peptide 610 $aTRPV1 610 $aion channels 610 $atransient receptor potential 610 $a2D gel electrophoresis 610 $aMALDI-TOF MS(/MS) 610 $aTRPV4 610 $aoverproduction 610 $asulfur mustard 610 $aoxidative stress 610 $agraft versus host disease 610 $amenthol 610 $atopical 610 $achemosensor 610 $aAP18 610 $acalcium signalling 610 $amucosal epithelium 610 $acuneate nucleus 610 $aproduction platform 610 $aTRPC channels 610 $aulcerative colitis 610 $achannel structure 610 $axerostomia 610 $aneutrophils 610 $acardiovascular system 610 $aTRPC5 610 $aTRPC6 610 $aTRPC3 610 $aTRPC4 610 $acalcium signaling 610 $aprotein purification 610 $aadipose tissue 610 $atransient receptor potential (TRP) channels 610 $asodium 610 $aTH17 610 $adiacylglycerol 610 $ahypersensitivity 610 $aTRPY1 610 $aGABAB 610 $aHEK293 610 $athrombosis 610 $aion channel 610 $aTRPC 610 $apathophysiology 610 $aSMAD 610 $atoxicology 610 $aendothelium 610 $acalcium 610 $aproteomics 610 $aTRPA1 610 $asalivary glands 610 $aTRP channels 610 $alipid mediators 610 $asensors 610 $aradiation 610 $aTRPM4 channel 610 $ahuman medulla oblongata 610 $amGluR1 610 $asmall molecules 610 $aTRPC3 pharmacology 615 7$aMedicine 700 $aDietrich$b Alexander$0764160 801 0$bScCtBLL 801 1$bScCtBLL 906 $aBOOK 912 $a9910674009603321 996 $aTRP Channels in Health and Disease$93059186 997 $aUNINA