LEADER 02257nam 2200385 450 001 9910673907603321 005 20230624124104.0 024 7 $a10.3390/books978-3-0365-2923-3 035 $a(CKB)5400000000042880 035 $a(NjHacI)995400000000042880 035 $a(EXLCZ)995400000000042880 100 $a20230624d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aColorectal Cancer $eFrom Pathophysiology to Novel Therapeutic Approaches /$fedited by Valeria Barresi 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2022. 215 $a1 online resource (284 pages) 311 $a3-0365-2922-5 330 $aColorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions. 517 $aColorectal Cancer 606 $aColon (Anatomy)$xCancer 606 $aRectum$xCancer 615 0$aColon (Anatomy)$xCancer. 615 0$aRectum$xCancer. 676 $a616.994347 702 $aBarresi$b Valeria 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910673907603321 996 $aColorectal cancer$92366401 997 $aUNINA