LEADER 04046nam 2200361 450 001 9910673906903321 005 20230703110549.0 035 $a(CKB)5700000000300442 035 $a(NjHacI)995700000000300442 035 $a(EXLCZ)995700000000300442 100 $a20230703d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGenetics of Prader-Willi syndrome /$fMerlin G. Butler, David E. Godler 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2022. 215 $a1 online resource (224 pages) 311 $a3-0365-5025-9 327 $aAbout the Editors -- Special Issue: Genetics of Prader-Willi Syndrome -- Single-Case Study of Appetite Control in Prader-Willi Syndrome, Over 12-Years by the Indian Extract Caralluma fimbriata -- Venous Thromboembolism in Prader-Willi Syndrome: A Questionnaire Survey -- The Global Prader-Willi Syndrome Registry: Development, Launch, and Early Demographics -- Early Diagnosis in Prader-Willi Syndrome Reduces Obesity and Associated Co-Morbidities -- Defining Mental and Behavioural Disorders in Genetically Determined Neurodevelopmental Syndromes with Particular Reference to Prader-Willi Syndrome -- Age Distribution, Comorbidities and Risk Factors for Thrombosis in Prader-Willi Syndrome -- Prader-Willi-Like Phenotype Caused by an Atypical 15q11.2 Microdeletion -- Food and Non-Food-Related Behavior across Settings in Children with Prader-Willi Syndrome -- Clinical Observations and Treatment Approaches for Scoliosis in Prader-Willi Syndrome -- The Potential Role of Activating the ATP-Sensitive Potassium Channel in the Treatment of Hyperphagic Obesity -- Growth Trajectories in Genetic Subtypes of Prader-Willi Syndrome -- The Gut Microbiota Profile in Children with Prader-Willi Syndrome -- A 24-Week Physical Activity Intervention Increases Bone Mineral Content without Changes in Bone Markers in Youth with PWS -- Genetic Subtype-Phenotype Analysis of Growth Hormone Treatment on Psychiatric Behavior in Prader-Willi Syndrome -- Pharmacogenetic Testing of Cytochrome P450 Drug Metabolizing Enzymes in a Case Series of Patients with Prader-Willi Syndrome. 330 $aPrader-Willi syndrome (PWS) is a complex genomic imprinting disorder associated with a spectrum of medical, cognitive, behavioural, and psychiatric problems and is also the most common cause of life-threatening obesity that can be effectively treated with hormone therapy and restricted diet, if detected early. PWS is usually caused by the loss of the paternally inherited 15q11.2-q13 region and abnormal expression of genes within that region and beyond. While some genotype-phenotype correlations with delineation of clinical characteristics and natural history have emerged when comparing the three main molecular classes of PWS (maternal uniparental disomy (UPD) 15, imprinting centre defect, and deletion of paternal 15q11-q13), better awareness and informative biomarkers are still needed. These could facilitate early diagnosis, counseling, prognostic testing, as well as patient stratification for clinical trials, to improve outcomes for the affected children and their families. This Special Issue will comprise reviews and original research articles focused on the recent advances of genetics/genomics, testing, and epigenetic processes along with clinical description, co-morbidities, and natural history of PWS. Current and future directions with focus on improved screening, diagnosis, and treatment will be addressed in this rare neurodevelopmental genetic imprinting disorder influenced by the PWS genetic subtypes. 606 $aPrader-Willi syndrome 615 0$aPrader-Willi syndrome. 676 $a618.9285884 700 $aButler$b Merlin G.$01261076 702 $aGodler$b David E. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910673906903321 996 $aGenetics of Prader-Willi syndrome$93394364 997 $aUNINA LEADER 03239nam 22005655 450 001 996547968803316 005 20231214145433.0 010 $a981-19-3032-5 024 7 $a10.1007/978-981-19-3032-4 035 $a(CKB)5600000000511200 035 $a(DE-He213)978-981-19-3032-4 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/93997 035 $a(MiAaPQ)EBC7120669 035 $a(Au-PeEL)EBL7120669 035 $a(OCoLC)1351746877 035 $a(PPN)265861195 035 $a(EXLCZ)995600000000511200 100 $a20240605d2022 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDatabase Principles and Technologies ? Based on Huawei GaussDB /$fby Huawei Technologies Co., Ltd 205 $a1st ed. 2023. 210 $aSingapore$cSpringer Nature$d2023 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (XIII, 314 p. 1 illus.) 311 $a981-19-3031-7 327 $aChapter 1. Introduction to Databases -- Chapter 2. Basic Knowledge of Database -- Chapter 3. Getting Started with SQL Syntax -- Chapter 4. SQL Syntax Categories -- Chapter 5. Database Security Fundamentals -- Chapter 6. Database Development Environment -- Chapter 7. Database Design Fundamentals -- Chapter 8. Introduction to Huawei Cloud Database GaussDB.-. 330 $aThis open access book contains eight chapters that deal with database technologies, including the development history of database, database fundamentals, introduction to SQL syntax, classification of SQL syntax, database security fundamentals, database development environment, database design fundamentals, and the application of Huawei?s cloud database product GaussDB database. This book can be used as a textbook for database courses in colleges and universities, and is also suitable as a reference book for the HCIA-GaussDB V1.5 certification examination. The Huawei GaussDB (for MySQL) used in the book is a Huawei cloud-based high-performance, highly applicable relational database that fully supports the syntax and functionality of the open source database MySQL. All the experiments in this book can be run on this database platform. As the world?s leading provider of ICT (information and communication technology) infrastructure and smart terminals, Huawei?s products range from digital data communication, cyber security, wireless technology, data storage, cloud computing, and smart computing to artificial intelligence. 606 $aDatabase management 606 $aDatabase Management 610 $aDatabase 610 $acertification 610 $aHuawei 610 $aGaussDB 610 $abig data 610 $aMySQL 615 0$aDatabase management. 615 14$aDatabase Management. 676 $a005.74 700 $aHuawei Technologies Co$b Ltd$4aut$4http://id.loc.gov/vocabulary/relators/aut$01271678 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996547968803316 996 $aDatabase Principles and Technologies ? Based on Huawei GaussDB$92995966 997 $aUNISA