LEADER 03627nam 22006375 450 001 9910672449203321 005 20230824193915.0 010 $a981-9900-78-6 024 7 $a10.1007/978-981-99-0078-7 035 $a(MiAaPQ)EBC7207233 035 $a(Au-PeEL)EBL7207233 035 $a(CKB)26186233500041 035 $a(DE-He213)978-981-99-0078-7 035 $a(PPN)26820618X 035 $a(EXLCZ)9926186233500041 100 $a20230220d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aG Protein-Coupled Receptors $eImmobilization and Applications in Drug Discovery /$fby Xinfeng Zhao, Qian Li, Jing Wang, Qi Liang, Jia Quan 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (100 pages) 225 1 $aSpringerBriefs in Molecular Science,$x2191-5415 311 08$aPrint version: Zhao, Xinfeng G Protein-Coupled Receptors Singapore : Springer,c2023 9789819900770 320 $aIncludes bibliographical references. 327 $aG Protein-Coupled Receptors -- Purification of G Protein-Coupled Receptors -- Oriented Immobilization of G Protein-Coupled Receptors -- Key Biochemical Aspects of Drug-Target Interactions -- Immobilized GPCRs in Drug-Receptor Interaction Analysis -- Immobilized GPCRs in Compound Screening. 330 $aThis book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the ?post-structural biology? era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities. 410 0$aSpringerBriefs in Molecular Science,$x2191-5415 606 $aAnalytical chemistry 606 $aBiochemistry 606 $aPharmaceutical chemistry 606 $aPharmaceutical chemistry 606 $aAnalytical Chemistry 606 $aChemical Biology 606 $aMedicinal Chemistry 606 $aPharmaceutics 615 0$aAnalytical chemistry. 615 0$aBiochemistry. 615 0$aPharmaceutical chemistry. 615 0$aPharmaceutical chemistry. 615 14$aAnalytical Chemistry. 615 24$aChemical Biology. 615 24$aMedicinal Chemistry. 615 24$aPharmaceutics. 676 $a615.19 700 $aZhao$b Xinfeng$01335427 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910672449203321 996 $aG Protein-Coupled Receptors$93374644 997 $aUNINA