LEADER 03726nam 2200601 450 001 996308834003316 005 20221206182727.0 024 7 $a10.2478/9788376560564 035 $a(CKB)2670000000528798 035 $a(SSID)ssj0001537885 035 $a(PQKBManifestationID)11876286 035 $a(PQKBTitleCode)TC0001537885 035 $a(PQKBWorkID)11522038 035 $a(PQKB)10805877 035 $a(WaSeSS)IndRDA00058672 035 $a(DE-B1597)212029 035 $a(OCoLC)1013942220 035 $a(OCoLC)958034648 035 $a(DE-B1597)9788376560564 035 $a(MiAaPQ)EBC1249831 035 $a(Au-PeEL)EBL1249831 035 $a(CaPaEBR)ebr11055003 035 $a(OCoLC)939262640 035 $a(EXLCZ)992670000000528798 100 $a20150602h20132013 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHistamine H4 receptor $ea novel drug target for immunoregulation and inflammation /$fHolger Stark 210 1$aLondon, England :$cVersita, Versita Limited,$d2013. 210 4$d©2013 215 $a1 online resource (368 pages) $cillustrations; digital, PDF file(s) 225 0 $aVersita discipline : Chemistry, Life Sciences 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a83-7656-055-7 311 0 $a83-7656-056-5 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tPreface --$tChapter 1 The histamine H4 receptor story --$tChapter 2 Histamine H4 Receptor Ligands --$tChapter 3 Histamine Metabolism --$tChapter 4 Histamine Receptors and Inflammatory Cells --$tChapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders --$tChapter 6 Histamine in Atopic Disorders: Atopic Dermatitis and Pruritus --$tChapter 7 Non-professional Histamine Producing Cells, Immune Responses and Autoimmunity --$tChapter 8 Histamine in Cancer --$tChapter 9 Non Receptor-mediated Histamine Actions --$tChapter 10 Perspectives in H4R Research and Therapeutic Exploitation --$tList of Figures --$tList of Tables --$tIndex 330 $aH4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed. 606 $aHistamine 610 $aG protein coupled receptors, H4R ligands, Inflammation, Autoimmune Disorders, Pruritus, Asthma, Allergy, Cancer, Drug Development, Drug Target, Clinical Candidates, Biogenic Amin. 615 0$aHistamine. 676 $a612.01575 700 $aStark$b Holger$0802446 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996308834003316 996 $aHistamine H4 receptor$91980461 997 $aUNISA LEADER 03058nam 2200637 450 001 9910671172403321 005 20170919181014.0 010 $a84-9031-520-5 035 $a(CKB)2560000000149210 035 $a(EBL)3220579 035 $a(OCoLC)924644290 035 $a(SSID)ssj0001468010 035 $a(PQKBManifestationID)11967774 035 $a(PQKBTitleCode)TC0001468010 035 $a(PQKBWorkID)11521532 035 $a(PQKB)10280879 035 $a(MiAaPQ)EBC3220579 035 $a(OCoLC)991996725 035 $a(FlNmELB)ELB56927 035 $a(EXLCZ)992560000000149210 100 $a20140718d2013 uy 0 101 0 $aspa 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 13$aEl derecho penal entre la ley y el juez $eestudios de derecho penal /$fGiovanni Fiandaca ; presentacio?n de Luis Miguel Reyna Alfaro ; traduccio?n a cargo de Karen Ventura Saavedra 210 1$aMadrid :$cDykinson,$d[2013] 215 $a1 online resource (206 p.) 225 1 $aCuadernos "Luis Jime?nez de Asu?a" ;$v39 300 $aDescription based upon print version of record. 311 $a84-9031-376-8 327 $aEL DERECHO PENAL ENTRE LA LEY Y EL JUEZ: ESTUDIOS DE DERECHO PENAL; PA?GINA LEGAL; I?NDICE; ADVERTENCIA; PRESENTACIO?N A LA EDICIO?N EN ESPAN?OL; NOTA DEL AUTOR A LA EDICIO?N EN ESPAN?OL*; PREFACIO A LA EDICIO?N ITALIANA; SECCIO?N PRIMERA; LA LEGALIDAD PENAL EN LOS EQUILIBRIOS DEL SISTEMA POLI?TICO-CONSTITUCIONAL * **; EL JUEZ ENTRE JUSTICIA Y DEMOCRACIA EN LA SOCIEDAD COMPLEJA*; HERMENE?UTICA Y APLICACIO?N JUDICIAL DEL DERECHO PENAL*; DERECHO PENAL Y PROCESO*; CONTROL DE RACIONALIDAD Y LEGISLACIO?N PENAL*; PENSAR Y ORDENAR EL MU?LTIPLO*; SECCIO?N SEGUNDA; ¿LA OFENSIVIDAD ES UN PRINCIPIO CODIFICABLE?* 327 $aOBSERVACIONES ACERCA DE LA REGULACIO?N DE LA IMPUTABILIDAD EN EL PROYECTO GROSSO*I. Crisis del concepto de imputabilidad y perspectivas de reforma del Co?digo; II. Propuestas de nueva regulacio?n de los casos de incapacidad autoprocurada; LA JUSTICIA DE MENORES COMO LABORATORIO EXPERIMENTAL DE INNOVACIONES EXTENSIBLES AL DERECHO PENAL COMU?N 410 0$aCuadernos "Luis Jime?nez de Asu?a" ;$v39. 606 $aCriminal law$xInterpretation and construction 606 $aCriminal law$xPhilosophy 606 $aJudicial discretion 606 $aDerecho Penal$xFilosofi?a 606 $aDerecho Penal$xInterpretacio?n 606 $aPoder discrecional de los jueces 615 0$aCriminal law$xInterpretation and construction. 615 0$aCriminal law$xPhilosophy. 615 0$aJudicial discretion. 615 4$aDerecho Penal$xFilosofi?a. 615 4$aDerecho Penal$xInterpretacio?n. 615 4$aPoder discrecional de los jueces. 676 $a3450072 700 $aFiandaca$b Giovanni$0294019 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910671172403321 996 $aEl derecho penal entre la ley y el juez$93056593 997 $aUNINA LEADER 03005nam 2200649 450 001 9910810755503321 005 20200520144314.0 010 $a0-8131-8478-9 010 $a0-8131-3397-1 010 $a0-8131-5071-X 035 $a(CKB)3710000000333878 035 $a(EBL)1914999 035 $a(SSID)ssj0001401498 035 $a(PQKBManifestationID)12618528 035 $a(PQKBTitleCode)TC0001401498 035 $a(PQKBWorkID)11350301 035 $a(PQKB)10016316 035 $a(OCoLC)897141673 035 $a(MdBmJHUP)muse43722 035 $a(Au-PeEL)EBL1914999 035 $a(CaPaEBR)ebr11009741 035 $a(CaONFJC)MIL690681 035 $a(OCoLC)900343565 035 $a(MiAaPQ)EBC1914999 035 $a(EXLCZ)993710000000333878 100 $a20150205h20101983 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBlack liberation in Kentucky $eemancipation and freedom, 1862-1884 /$fVictor B. Howard 205 $aPaperback edition. 210 1$aLexington, Kentucky :$cThe University Press of Kentucky,$d2010. 210 4$d©1983 215 $a1 online resource (231 p.) 300 $aIncludes index. 311 $a1-322-59399-X 311 $a0-8131-1433-0 320 $aIncludes bibliographical references and index. 327 $aCover; Title; Copyright; Contents; Preface; Introduction; 1 Kentucky Responds to War; 2 The Army and the Slave; 3 Emancipation; 4 Military Enrollment; 5 Slaves Go to War; 6 From Soldier to Freedman; 7 The Search for Work; 8 Families in Transition; 9 The Testimony Question; 10 Black Suffrage; 11 Equal Education?; Epilogue; Notes; Manuscript Sources and Government Documents; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; W 330 $aKentucky occupied an unusual position with regard to slavery during the Civil War as well as after. Since the state never seceded, the emancipation proclamation did not free the majority of Kentucky's slaves; in fact, Kentucky and Delaware were the only two states where legal slavery still existed when the thirteenth amendment was adopted by Congress. Despite its unique position, no historian before has attempted to tell the experience of blacks in the Commonwealth during the Civil War and Reconstruction.Victor B. Howard's Black Liberation in Kentucky fills this void in the history of slavery 606 $aAfrican Americans$zKentucky$xHistory$y19th century 606 $aReconstruction (U.S. history, 1865-1877)$zKentucky 607 $aKentucky$xHistory$yCivil War, 1861-1865 607 $aKentucky$xRace relations 615 0$aAfrican Americans$xHistory 615 0$aReconstruction (U.S. history, 1865-1877) 676 $a976.9/00496073 700 $aHoward$b Victor B.$01122260 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910810755503321 996 $aBlack liberation in Kentucky$93958437 997 $aUNINA