LEADER 05578nam 2200565 450 001 9910794539803321 005 20220822042907.0 010 $a1-9788-0142-4 010 $a1-9788-0144-0 024 7 $a10.36019/9781978801448 035 $a(CKB)4100000011982509 035 $a(MiAaPQ)EBC6678246 035 $a(Au-PeEL)EBL6678246 035 $a(OCoLC)1260340953 035 $a(DE-B1597)600705 035 $a(DE-B1597)9781978801448 035 $a(MdBmJHUP)musev2_102370 035 $a(EXLCZ)994100000011982509 100 $a20220327d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAnthony Cerami $ea life in translational medicine /$fConrad Keating 210 1$aNew Brunswick :$cRutgers University Press,$d[2021] 210 4$dŠ2021 215 $a1 online resource (219 pages) 311 $a1-9788-0140-8 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Hard work -- The Rockefeller effect -- The shaping of a scientific mind -- The Rockefeller University and the broad horizon -- Diabetes: The creation of the hemoglobin arc test -- Glucose, aging, the cross-linking of biology and business -- The conceptual breakthrough -- Cachectin -- Tumor necrosis factor -- Leaving the Rockefeller University: The end of the dream -- Philanthropy goes awry -- Translation in transition -- Anti-TNF therapy: Changing the pharmaceutical landscape -- Taking on big pharma. 330 $a"Since the turn of the new millennium, 'translational research', the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe. Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline's most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in the hope of improving human health will find inspiration in examining the sacrifices and achievements of Cerami's career in translational medicine. During his three decades at Rockefeller University his cross-disciplinary and laboratory-without-wall approach established 'rational drug design' as the most effective means of advancing the fields of parasitology, hematology, immunology, metabolism, therapeutics and molecular medicine. Cerami's story and that of the evolution of translation are intimately entwined: the contours of Cerami's career shaped by developments in translation, and in exchange, the field itself molded by Cerami's work. To understand one is to understand the other. By examining the life of this often overlooked biochemist it is possible to intimately focus on the ideas and thought processes of a scientist who has helped to define the great acceleration in translational research over the past half century - research that, knowingly or otherwise, has most likely affected the life of almost everyone on the planet. We also gain a better understanding of the febrile creative atmosphere that percolated through the laboratories leading the way in translational medicine, and gain insight into the art, science, successes, failures and providence that underlie major scientific breakthroughs. Anybody interested in the questions of where modern medicines come from, how health outcomes around the globe are affected by research and imagination, and where the future of drug discovery is leading, will be rewarded by exploring Cerami's life in translation. This book is not restricted to those with a professional interest in science, because anyone dedicated to living a life of creativity and discovery will be rewarded by reading this book. In many respects, Cerami's life reflects the modern metaphor of the 'American dream' with his journey from humble beginnings on a chicken farm in rural New Jersey, to occupying a place in the highest echelons of the US scientific establishment. His journey in translational medicine was propelled forward by two obsessions; the idea that he could help people who were sick, and the excitement of discovery. In following his two great passions, he trained a generation of specialists in translational medicine that continue to transform our understanding of, and treatments for, human disease. Anthony Cerami's work has shown how science has become an important force for social change by laying the foundations of modern translational medicine"--$cProvided by publisher. 606 $aMedicine$xResearch 606 $aMedical scientists$vBiography 606 $aDrugs$xDesign 606 $aBiochemists$vBiography 610 $aAnthony Cerami, Translational Medicine, Medicine, therapeutics, Rockefeller University, biochemistry, malaria vaccine, tropical diseases, Africa, immunology, metabolic diseases, diabetes, medical research, Ph.D., pathogenesis, Harvard, Crohn's disease. 615 0$aMedicine$xResearch. 615 0$aMedical scientists 615 0$aDrugs$xDesign. 615 0$aBiochemists 676 $a610.72 700 $aKeating$b Conrad$0788893 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910794539803321 996 $aAnthony Cerami$93732889 997 $aUNINA LEADER 01843nam 2200445z- 450 001 9910689795803321 005 20161209103748.0 035 $a(CKB)5860000000033727 035 $a(BIP)010686351 035 $a(EXLCZ)995860000000033727 100 $a20220406c2004uuuu -u- - 101 0 $aeng 200 10$aSeaport security, cargo inspection, and hazardous materials transportation $efield hearing before the Subcommittee on Surface Transportation and Merchant Marine, Committee on Commerce, Science, and Transportation, United States Senate, One Hundred Seventh Congress, second session, January 11, 2002 215 $a1 online resource (iii, 43 p.) 311 $a0-16-071626-8 517 $aSeaport security, cargo inspection, and hazardous materials transportation 606 $aHarbors$xSecurity measures$zUnited States 606 $aMarine terminals$xSecurity measures$zUnited States 606 $aFreight and freightage$xSecurity measures$zUnited States 606 $aCustoms inspection$zUnited States 606 $aHazardous substances$xTransportation$zUnited States 606 $aNational security$zUnited States 610 $aHarbors 610 $aFreight and freightage 610 $aHazardous substances 610 $aNational security 610 $aTransportation 610 $aBusiness & economics 610 $aTechnology & engineering 610 $aPolitical science 615 0$aHarbors$xSecurity measures 615 0$aMarine terminals$xSecurity measures 615 0$aFreight and freightage$xSecurity measures 615 0$aCustoms inspection 615 0$aHazardous substances$xTransportation 615 0$aNational security 906 $aBOOK 912 $a9910689795803321 996 $aSeaport security, cargo inspection, and hazardous materials transportation$93144692 997 $aUNINA LEADER 06668nam 22008535 450 001 9910647771303321 005 20250610122544.0 010 $a3-031-24866-X 024 7 $a10.1007/978-3-031-24866-5 035 $a(MiAaPQ)EBC7191450 035 $a(Au-PeEL)EBL7191450 035 $a(CKB)26089877900041 035 $a(DE-He213)978-3-031-24866-5 035 $a(PPN)268204462 035 $a(EXLCZ)9926089877900041 100 $a20230204d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aLearning and Intelligent Optimization $e16th International Conference, LION 16, Milos Island, Greece, June 5?10, 2022, Revised Selected Papers /$fedited by Dimitris E. Simos, Varvara A. Rasskazova, Francesco Archetti, Ilias S. Kotsireas, Panos M. Pardalos 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (576 pages) 225 1 $aLecture Notes in Computer Science,$x1611-3349 ;$v13621 311 08$aPrint version: Simos, Dimitris E. Learning and Intelligent Optimization Cham : Springer International Publishing AG,c2023 9783031248658 327 $aInvited Papers -- Optimal Scheduling of the Leaves of a Tree and the SVO Frequencies of Languages -- From Design of Experiments to Combinatorics of Disasters: A Conceptual Framework for Disaster Exercises -- Separating two polyhedra utilizing alternative theorems and penalty function -- Contributed Papers. -A Composite Index Method for Optimization Benchmarking -- Optimal Energy Management of Microgrid Using Multi-objective Optimisation Approach -- A Stochastic Alternating Balance k-Means Algorithm for Fair Clustering -- Binary Black Widow Optimization Algorithm for Feature Selection Problems -- Learning to Solve a Stochastic Orienteering Problem with Time Windows -- ML-based approach for accelerating global search algorithm for solving multicriteria problems -- The Skewed Kruskal algorithm -- Bounds for sparse solutions of K-SVCR multi-class classification model -- Integer Linear Programming in Solving an Optimization Problem at the Mixing Department of the Metallurgical Production -- Realtime Gray-Box Algorithm Configuration -- Dynamic urban solid waste management system for smart cities -- Single MCMC Chain Parallelisation on Decision Trees -- Single MCMC Chain Parallelisation on Decision Trees -- Competitive supply allocation in a distribution network under overproduction -- Safe-exploration of control policies from safe-experience via Gaussian Processes -- Bayesian Optimization in Wasserstein Spaces -- Network Vulnerability Analysis in Wasserstein Spaces -- BERT Self-Learning Approach with Limited Labels for Document Classification -- Autonomous Learning Optimization for Deep Learning -- Optimizing Data Augmentation Policy through Random Unidimensional Search -- Evaluating Student Behaviour on the MathE Platform - Clustering Algorithms Approaches -- Unsupervised Training for Neural TSP Solver -- Comparing surrogate models for tuning optimization algorithms -- Search and Score-based Waterfall Auction Optimization -- Survey on KNN Methods in Data Science -- Constrained Shortest Path and Hierarchical Structures -- Investigation of Graph Neural Networks for Instance Segmentation of Industrial Point Cloud Data -- Fitness landscape ruggedness impact on PSO in dealing with three variants of the travelling salesman problem -- A Multi-UAVs? Provider Model for the provision of 5G Service Chains: a game theoretic approach -- Metabolic Syndrome Risk Forecasting on Elderly with ML Techniques -- Airport Digital Twins for Resilient Disaster Management Response -- Strategies for Surviving Aggressive Multiparty Repeated Standoffs -- A Hybridization of GRASP and UTASTAR for Solving the Vehicle Routing Problem with Pickups and Deliveries and 3D Loading Constraints -- Packing hypertrees and the k-cut problem in Hypergraphs -- Maximizing the Eigenvalue-Gap and Promoting Sparsity ofDoubly Stochastic Matrices with PSO -- Value of Information in the Mean-Square Case and its Application to the Analysis of Financial Time-Series Forecast. 330 $aThis book constitutes the refereed proceedings of the 16th International Conference on Learning and Intelligent Optimization, LION 16, which took place in Milos Island, Greece, in June 2022. The 36 full papers and 3 short papers presented in this volume were carefully reviewed and selected from 60 submissions. LION deals with automatic solver configuration, parallel methods, intelligent optimization, nature-inspired algorithms, hard combinatorial optimization problems, DC learning, computational intelligence, and others. The contributions were organized in topical sections as follows: Invited Papers; Contributed Papers. 410 0$aLecture Notes in Computer Science,$x1611-3349 ;$v13621 606 $aNumerical analysis 606 $aComputer science$xMathematics 606 $aMathematical statistics 606 $aComputer science 606 $aArtificial intelligence 606 $aSocial sciences$xData processing 606 $aComputers 606 $aNumerical Analysis 606 $aProbability and Statistics in Computer Science 606 $aTheory of Computation 606 $aArtificial Intelligence 606 $aComputer Application in Social and Behavioral Sciences 606 $aComputing Milieux 606 $aAprenentatge automātic$2thub 606 $aOptimitzaciķ matemātica$2thub 606 $aProcessament de dades$2thub 608 $aCongressos$2thub 608 $aLlibres electrōnics$2thub 615 0$aNumerical analysis. 615 0$aComputer science$xMathematics. 615 0$aMathematical statistics. 615 0$aComputer science. 615 0$aArtificial intelligence. 615 0$aSocial sciences$xData processing. 615 0$aComputers. 615 14$aNumerical Analysis. 615 24$aProbability and Statistics in Computer Science. 615 24$aTheory of Computation. 615 24$aArtificial Intelligence. 615 24$aComputer Application in Social and Behavioral Sciences. 615 24$aComputing Milieux. 615 7$aAprenentatge automātic 615 7$aOptimitzaciķ matemātica 615 7$aProcessament de dades 676 $a519.3 676 $a006.31 702 $aSimos$b Dimitris E. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910647771303321 996 $aLearning and Intelligent Optimization$9773725 997 $aUNINA