LEADER 04139nam 2200409 450 001 9910647494603321 005 20230326224751.0 024 7 $a10.5772/intechopen.100842 035 $a(CKB)5680000000300329 035 $a(NjHacI)995680000000300329 035 $a(EXLCZ)995680000000300329 100 $a20230326d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBRCA1 and BRCA2 Mutations $eDiagnostic and Therapeutic Implications /$fEdited by Mani T. Valarmathi 210 1$aLondon :$cIntechOpen,$d2023. 210 4$d©2023 215 $a1 online resource (134 pages) 311 $a1-80356-806-2 311 $a1-80356-807-0 320 $aIncludes bibliographical references and index. 327 $aPreface -- Section 1 Hereditary Breast and Ovarian Cancer Syndrome -- Chapter 1 Introductory Chapter: The Influence of BRCA1/2 Genes Mutations on Hereditary Breast and Ovarian Cancer Syndrome - Is it in your Genes? by Mani T. Valarmathi Section 2 BRCA Discovery -- Chapter 2 Discovery of BRCA Mutations: Historical Perspective of Its Scientific, Clinical and Social Impact by Natalia B. Burachik, Ana Laura Ortiz and Edith C. Kordon Section 3 BRCA Structure and Function -- Chapter 3 BRCA Biological Functions by Divya Bhargavi Pulukuri, Vijaya Babu Penke, Divya Jyothi Palati, Prudvi Raj Pulla, Shanker Kalakotla and Siddhartha Lolla -- Chapter 4 The Fundamental Role of BARD1 Mutations and Their Applications as a Prognostic Biomarker for Cancer Treatment by Yousef M. Hawsawi and Anwar Shams -- Section 4 BRCA-Associated Cancers -- Chapter 5 BRCA Gene Mutations and Prostate Cancer by Gvantsa Kharaishvili, Mariam Kacheishvili and Giorgi Akhvlediani -- Chapter 6 Genomic Consequences of Ovarian Cancer with Respect to DNA Damage and Repair Mechanism by Sonali Verma, Gresh Chander, Ruchi Shah and Rakesh Kumar -- Section 5 BRCA Genetic Testing and Counselling -- Chapter 7 Implications of BRCA1 and BRCA2 Mutations in Mexico by Carlos Arturo Gonzalez Nun?ez, Paula Anel Cabrera Galeana, Sandy Ruiz Cruz and Alexandra Garcilazo Reyes -- Chapter 8 Quality of Life is Essential: Implications for Diagnosis and Treatment for BRCA1/2 Germline Mutations by Yuliana Sanchez Contreras, Brigney Isvettia Aceves Poveda, David Neri Acosta Gutierrez and Rosa Maria Alvarez Gomez. 330 $aMutations in the BRCA1/2 genes are the most common cause of hereditary breast and ovarian cancer (HBOC), and HBOC is an autosomal dominant cancer predisposition syndrome. Individuals with HBOC have a high risk for breast and ovarian cancers and a moderate risk for other cancers, such as prostate, pancreatic, melanoma, and fallopian tube cancers. The goal of screening individuals at high risk of familial cancer is either prevention (such as a change in lifestyle or diet) or early detection of cancer. The identification of BRCA mutation carriers is important, since increased surveillance, drug therapy, and prophylactic surgery can reduce cancer-related morbidity and mortality. In recent years, there has been substantial development in BRCA-associated hereditary breast and/or breast-ovarian cancer research and its clinical applications. In this context, this book consolidates the recent advances in BRCA-related cancer biology and therapeutics, covering a wide spectrum of interrelated topics. Chapters cover a wide range of topics, such as BRCA discovery, BRCA structure and function, BRCA-associated cancers, BRCA genetic testing and counselling, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants. 517 $aBRCA1 and BRCA2 Mutations 606 $aBreast$xCancer$xGenetic aspects 615 0$aBreast$xCancer$xGenetic aspects. 676 $a616.99449042 702 $aValarmathi$b Mani T. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910647494603321 996 $aBRCA1 and BRCA2 Mutations$93075763 997 $aUNINA LEADER 07969nam 2200649 450 001 9910827311803321 005 20230807221612.0 010 $a0-8014-5559-6 010 $a0-8014-5560-X 024 7 $a10.7591/9780801455605 035 $a(CKB)3710000000462626 035 $a(EBL)3425985 035 $a(SSID)ssj0001533121 035 $a(PQKBManifestationID)12645267 035 $a(PQKBTitleCode)TC0001533121 035 $a(PQKBWorkID)11484120 035 $a(PQKB)11250144 035 $a(MiAaPQ)EBC3425985 035 $a(OCoLC)1080551342 035 $a(MdBmJHUP)muse58536 035 $a(DE-B1597)496495 035 $a(OCoLC)918150494 035 $a(DE-B1597)9780801455605 035 $a(Au-PeEL)EBL3425985 035 $a(CaPaEBR)ebr11084144 035 $a(CaONFJC)MIL821878 035 $a(EXLCZ)993710000000462626 100 $a20150813h20152015 uy 0 101 0 $aeng 135 $aur|nu---|u||u 181 $ctxt 182 $cc 183 $acr 200 00$aMonarchs in a changing world $ebiology and conservation of an iconic butterfly /$fedited by Karen S. Oberhauser, Kelly R. Nail, Sonia Altizer 210 1$aIthaca, New York ;$aLondon, [England] :$cComstock Publishing Associates, a division of Cornell University Press,$d2015. 210 4$d©2015 215 $a1 online resource (352 p.) 300 $aDescription based upon print version of record. 311 $a0-8014-5315-1 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tContents --$tPART I Model Programs for Citizen Science, Education, and Conservation /$rOberhauser, Karen S. --$tPART II Monarchs as Herbivores, Prey, and Hosts /$rRoode, Jacobus C. de --$tPART III Monarchs in a Changing Climate /$rNail, Kelly R. / Oberhauser, Karen S. --$tPART IV Conserving North American Monarch Butterflies /$rBrower, Lincoln P. / Fink, Linda S. --$tPART V New Perspectives on Monarch Migration, Evolution, and Population Biology /$rDavis, Andrew K. / Altizer, Sonia --$tReferences --$tContributors --$tIndex --$tColor Plates 330 $aMonarch butterflies are among the most popular insect species in the world and are an icon for conservation groups and environmental education programs. Monarch caterpillars and adults are easily recognizable as welcome visitors to gardens in North America and beyond, and their spectacular migration in eastern North America (from breeding locations in Canada and the United States to overwintering sites in Mexico) has captured the imagination of the public. Monarch migration, behavior, and chemical ecology have been studied for decades. Yet many aspects of monarch biology have come to light in only the past few years. These aspects include questions regarding large-scale trends in monarch population sizes, monarch interactions with pathogens and insect predators, and monarch molecular genetics and large-scale evolution. A growing number of current research findings build on the observations of citizen scientists, who monitor monarch migration, reproduction, survival, and disease. Monarchs face new threats from humans as they navigate a changing landscape marked by deforestation, pesticides, genetically modified crops, and a changing climate, all of which place the future of monarchs and their amazing migration in peril. To meet the demand for a timely synthesis of monarch biology, conservation and outreach, Monarchs in a Changing World summarizes recent developments in scientific research, highlights challenges and responses to threats to monarch conservation, and showcases the many ways that monarchs are used in citizen science programs, outreach, and education. It examines issues pertaining to the eastern and western North American migratory populations, as well as to monarchs in South America, the Pacific and Caribbean Islands, and Europe. The target audience includes entomologists, population biologists, conservation policymakers, and K-12 teachers. Contributors: Anurag A. Agrawal, Cornell University; Jared G. Ali, Michigan State University; Sonia Altizer, University of Georgia; Michael C. Anderson, Eden Prairie, Minnesota; Sophia M. Anderson, Eden Prairie, Minnesota; Kim Bailey, Georgia Department of Natural Resources; Rebecca Batalden, University of Minnesota; Kristen A. Baum, Oklahoma State University; Scott Hoffman Black, Xerces Society for Invertebrate Conservation; Brianna Borders, Xerces Society for Invertebrate Conservation; Lincoln P. Brower, Sweet Briar College; Wendy Caldwell, University of Minnesota; Mariana Cantú-Férnandez, Universidad Nacional Autónoma de México; Nicola Chamberlain, Harvard University; Sonya Charest, Montreal Insectarium; Andrew K. Davis, University of Georgia; Alma De Anda, Covina, California; Guadalupe del Rio Pesado, Alternare, A.C., Mexico; Janet Kudell-Ekstrum, USDA Forest Service; Linda S. Fink, Sweet Briar College; Mark Fishbein, Oklahoma State University; Juan Fernández-Haeger, University of Córdoba, Spain; Eligio García Serrano, Fondo Monarca, Mexico; Mark Garland, Cape May Monarch Monitoring Project; Brian Hayes, Monarch Teacher Network; Elizabeth Howard, Journey North; Mark D. Hunter, University of Michigan; Sarina Jepsen, Xerces Society for Invertebrate Conservation; Diego Jordano, University of Córdoba, Spain; Matthew C. Kaiser, University of Minnesota; Ridlon J. Kiphart, Texas Master Naturalists; Marcus R. Kronforst, University of Chicago; Jim Lovett, University of Kansas; Eric Lee-Mäder, Xerces Society for Invertebrate Conservation; Stephen B. Malcolm, Western Michigan University; Héctor Martínez-Torres, Universidad Nacional Autónoma de México; Susan Meyers, Stone Mountain Memorial Association; Erik A. Mollenhauer, Monarch Teacher Network; Mía Monroe, Xerces Society for Invertebrate Conservation; Eneida B. Montesinos-Patino, Monarch Butterfly Fund; Gail M. Morris, Southwest Monarch Study; Elisha K. Mueller, Oklahoma State University; Kelly R. Nail, University of Minnesota; Karen S. Oberhauser, University of Minnesota; Diego R. Pérez-Salicrup, Universidad Nacional Autónoma de México; Amanda A. Pierce, Emory University; John Pleasants, Iowa State University; Victoria Pocius, University of Kansas; Robert Michael Pyle, Northwest Lepidoptera Survey; M. Isabel Ramírez, Universidad Nacional Autónoma de México; Sergio Rasmann, University of California, Irvine; Gerald Rehfeldt, USDA Forest Service; Eduardo Rendón-Salinas, World Wildlife Fund-Mexico; Leslie Ries, National Socio-Environmental Synthesis Center; Jacobus C. de Roode, Emory University; Richard G. RuBino, Florida State University; Ann Ryan, University of Kansas; Cuauhtémoc Sáenz-Romero, Universidad Michoacana de San Nicolás de Hidalgo; Lidia Salas-Canela, Universidad Nacional Autónoma de México; Phil Schappert, Biophilia Consulting; Priya C. Shahani, Oregon State University; Benjamin H. Slager, Western Michigan University; Michelle J. Solensky, University of Jamestown; Douglas J. Taron, Chicago Academy of Sciences/Peggy Notebaert Nature Museum; Orley R. Taylor, University of Kansas; Rocío Treviño, Protección de la Fauna Mexicana A.C.; Francis X. Villablanca, California Polytechnic State University; Dick Walton, New Jersey Audubon/Cape May Bird Observatory; Ernest H. Williams, Hamilton College; Elisabeth Young-Isebrand, University of Minnesota; Myron P. Zalucki, University of Queensland; Raúl R. Zubieta, Universidad Nacional Autónoma de México 606 $aMonarch butterfly 606 $aMonarch butterfly$xConservation$zNorth America 615 0$aMonarch butterfly. 615 0$aMonarch butterfly$xConservation 676 $a595.78/9 702 $aOberhauser$b Karen S. 702 $aNail$b Kelly R. 702 $aAltizer$b Sonia 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910827311803321 996 $aMonarchs in a changing world$93974039 997 $aUNINA