LEADER 03211nam 2200517 450 001 9910554247203321 005 20220510214757.0 010 $a1-5036-3040-4 024 7 $a10.1515/9781503630406 035 $a(CKB)4100000012000471 035 $a(MiAaPQ)EBC6708305 035 $a(Au-PeEL)EBL6708305 035 $a(OCoLC)1265462215 035 $a(DE-B1597)609947 035 $a(OCoLC)1251737513 035 $a(DE-B1597)9781503630406 035 $a(PPN)259807257 035 $a(EXLCZ)994100000012000471 100 $a20220510d2021 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCyber threats and nuclear weapons /$fHerbert Lin 210 1$aStanford, California :$cStanford University Press,$d[2021] 210 4$d©2021 215 $a1 online resource (218 pages) 311 $a1-5036-3039-0 327 $aCover -- Contents -- Preface -- 1 Introduction and Background -- 2 The Cyber-Nuclear Connection -- 3 The U.S. Nuclear Enterprise -- 4 Cybersecurity Lessons for Nuclear Modernization -- 5 Cyber Risks in Selected Nuclear Scenarios -- 6 Designing the Cyber-Nuclear Future: Observations and Imperatives -- 7 Moving Forward -- Notes -- Bibliography -- Index. 330 $aThe technology controlling United States nuclear weapons predates the Internet. Updating the technology for the digital era is necessary, but it comes with the risk that anything digital can be hacked. Moreover, using new systems for both nuclear and non-nuclear operations will lead to levels of nuclear risk hardly imagined before. This book is the first to confront these risks comprehensively. With Cyber Threats and Nuclear Weapons, Herbert Lin provides a clear-eyed breakdown of the cyber risks to the U.S. nuclear enterprise. Featuring a series of scenarios that clarify the intersection of cyber and nuclear risk, this book guides readers through a little-understood element of the risk profile that government decision-makers should be anticipating. What might have happened if the Cuban Missile Crisis took place in the age of Twitter, with unvetted information swirling around? What if an adversary announced that malware had compromised nuclear systems, clouding the confidence of nuclear decision-makers? Cyber Threats and Nuclear Weapons, the first book to consider cyber risks across the entire nuclear enterprise, concludes with crucial advice on how government can manage the tensions between new nuclear capabilities and increasing cyber risk. This is an invaluable handbook for those ready to confront the unique challenges of cyber nuclear risk. 606 $aNuclear weapons$zUnited States 606 $aNuclear weapons$xSecurity measures$zUnited States 606 $aComputer security$zUnited States 615 0$aNuclear weapons 615 0$aNuclear weapons$xSecurity measures 615 0$aComputer security 676 $a355.02170973 700 $aLin$b Herbert$01093194 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910554247203321 996 $aCyber Threats and Nuclear Weapons$92815367 997 $aUNINA LEADER 08059nam 2200385 450 001 9910647214603321 005 20230327052132.0 010 $a3-0365-6319-9 035 $a(CKB)5680000000300202 035 $a(NjHacI)995680000000300202 035 $a(EXLCZ)995680000000300202 100 $a20230327d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAnimal models for study of pathophysiological mechanisms of hypertension and its complications /$fedited by Josef Zicha, Ivana Vane?c?kova? 210 1$aBasel, Switzerland :$cMDPI - Multidisciplinary Digital Publishing Institute,$d[2023] 210 4$d©2023 215 $a1 online resource (296 pages) 311 $a3-0365-6318-0 327 $aAbout the Editors vii -- Preface to "Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications" ix -- You-Lin Tain and Chien-Ning Hsu Hypertension of Developmental Origins: Consideration of Gut Microbiome in Animal Models Reprinted from: Biomedicines 2022, 10, 875, doi:10.3390/biomedicines10040875 1 -- Hiroki Ohara and Toru Nabika Genetic Modifications to Alter Blood Pressure Level Reprinted from: Biomedicines 2022, 10, 1855, doi:10.3390/biomedicines10081855 23 -- Yukio Yamori, Miki Sagara, Hideki Mori and Mari Mori Stroke-Prone SHR as Experimental Models for Cardiovascular Disease Risk Reduction in Humans Reprinted from: Biomedicines 2022, 10, 2974, doi:10.3390/biomedicines10112974 45 -- Kenichi Goto and Takanari Kitazono Chloride Ions, Vascular Function and Hypertension Reprinted from: Biomedicines 2022, 10, 2316, doi:10.3390/biomedicines10092316 57 -- Maria Sofia Vieira-Rocha, Joana Beatriz Sousa, Pilar Rodr´?guez-Rodr´?guez, Silvia Madaglena Arribas and Carmen Diniz Elevated Vascular Sympathetic Neurotransmission and Remodelling Is a Common Feature in a Rat Model of Foetal Programming of Hypertension and SHR Reprinted from: Biomedicines 2022, 10, 1902, doi:10.3390/biomedicines10081902 73 -- Pilar Rodr´?guez-Rodr´?guez, Ignacio Monedero-Cobeta, David Ramiro-Cortijo, Sophida Puthong, Begona? Quintana-Villamandos, Alicia Gil-Ram´?rez, Silvia Canas, ? et al. Slower Growth during Lactation Rescues Early Cardiovascular and Adipose Tissue Hypertrophy Induced by Fetal Undernutrition in Rats Reprinted from: Biomedicines 2022, 10, 2504, doi:10.3390/biomedicines10102504 91 -- Nejla Latic, Ana Zupcic, Danny Frauenstein and Reinhold G. Erben Activation of RAAS Signaling Contributes to Hypertension in Aged Hyp Mice Reprinted from: Biomedicines 2022, 10, 1691, doi:10.3390/biomedicines10071691 107 -- Nejla Latic, Mirko Peitzsch, Ana Zupcic, Jens Pietzsch and Reinhold G. Erben Long-Term Excessive Dietary Phosphate Intake Increases Arterial Blood Pressure, Activates the Renin-Angiotensin-Aldosterone System, and Stimulates Sympathetic Tone in Mice Reprinted from: Biomedicines 2022, 10, 2510, doi:10.3390/biomedicines10102510 119 -- Fedor Simko, Tomas Baka, Peter Stanko, Kristina Repova, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, et al. Sacubitril/Valsartan and Ivabradine Attenuate Left Ventricular Remodelling and Dysfunction in Spontaneously Hypertensive Rats: Different Interactions with the Renin-Angiotensin-Aldosterone System Reprinted from: Biomedicines 2022, 10, 1844, doi:10.3390/biomedicines10081844 131 -- Christina Hawlitschek, Julia Brendel, Philipp Gabriel, Katrin Schierle, Aida Salameh, Heinz-Gerd Zimmer and Beate Rassler How Effective Is a Late-Onset Antihypertensive Treatment? Studies with Captopril as Monotherapy and in Combination with Nifedipine in Old Spontaneously Hypertensive Rats Reprinted from: Biomedicines 2022, 10, 1964, doi:10.3390/biomedicines10081964 147 -- Beate Rassler, Christina Hawlitschek, Julia Brendel and Heinz-Gerd Zimme How Do Young and Old Spontaneously Hypertensive Rats Respond to Antihypertensive Therapy? Comparative Studies on the Effects of Combined Captopril and Nifedipine Treatment Reprinted from: Biomedicines 2022, 10, 3059, doi:10.3390/biomedicines10123059 161 -- Katarina Andelova, Barbara Szeiffova Bacova, Matus Sykora, Stanislav Pavelka, Hana Rauchova and Narcis Tribulova Cardiac Cx43 Signaling Is Enhanced and TGF-?1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRM Reprinted from: Biomedicines 2022, 10, 1707, doi:10.3390/biomedicines10071707 175 -- Hana Mal´?nsk´a, Martina Huttl, ¨ Irena Markov´a, Denisa Mikl´ankov´a, Silvie Hojn´a, Franti?sek Papou?sek, JanSilhav ? y, ´ et al. Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein Reprinted from: Biomedicines 2022, 10, 2066, doi:10.3390/biomedicines10092066 195 -- Silvie Hojn´a, Zoe Kotsaridou, Zdenka ? Vanourkov´a, ? Hana Rauchov´a, Michal Behuliak, Petr Kujal, Michaela Kadlecov´a, Josef Zicha and Ivana Van?eckov´a ? Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease Reprinted from: Biomedicines 2022, 10, 2509, doi:10.3390/biomedicines10102509 211 -- Yung-Mei Chao, Hana Rauchov ´a and Julie Y. H. Chan Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic L-NAME Treatment in Rats Reprinted from: Biomedicines 2022, 10, 2232, doi:10.3390/biomedicines10092232 225 -- Giovanna Castoldi, Raffaella Carletti, Silvia Ippolito, Isabella Villa, Biagio Palmisano, Simona Bolamperti, Alessandro Rubinacci, et al. Angiotensin II Modulates Calcium/Phosphate Excretion in Experimental Model of Hypertension: Focus on Bone Reprinted from: Biomedicines 2022, 10, 2928, doi:10.3390/biomedicines10112928 253 -- Jeehye Maeng and Kyunglim Lee Role of Translationally Controlled Tumor Protein (TCTP) in the Development of Hypertension and Related Diseases in Mouse Models Reprinted from: Biomedicines 2022, 10, 2722, doi:10.3390/biomedicines10112722 265. 330 $aEssential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories. 606 $aHypertension 615 0$aHypertension. 676 $a616.132 702 $aZicha$b Josef 702 $aVane?c?kova?$b Ivana 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910647214603321 996 $aAnimal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications$93012707 997 $aUNINA