LEADER 03100nam 2200385 450 001 9910647203903321 005 20230328022920.0 035 $a(CKB)5680000000300265 035 $a(NjHacI)995680000000300265 035 $a(EXLCZ)995680000000300265 100 $a20230328d2023 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNon-alcoholic Fatty Liver Disease $eNew Insight and Glance Into Disease Pathogenesis /$fedited by Ju-Seop Kang 210 1$aLondon :$cIntechOpen,$d2023. 210 4$dİ2023 215 $a1 online resource (ix, 156 pages) $cillustrations 311 $a1-83968-090-3 311 $a1-83968-091-1 327 $aPreface -- Section 1 Basic Concept and Molecular Aspect in the Development of NAFLD/NASH -- Chapter 1 Non-Alcoholic Fatty Liver Disease: Pathogenesis and the Significance of High-Density Lipoprotein as a Molecular Modifier by Ibrahim Kalle Kwaifa, Abdullahi S. Mainasara, Muhammad Lawal Jidda, Amrina Mohammad Amin, Garba Abdullahi, Faruku Ladan and Maryam Danyaro -- Chapter 2 Hepatic Lipid Homeostasis in NAFLD by Shuo Zhang, Bing Ji, Changqing Yang and Li Yang -- Chapter 3 Transcriptional Regulation by ERR and Its Role in NAFLD Pathogenesis by Brittney Hua, Ielyzaveta Slarve, Aditi A. Datta, Chenxi Xu, Chien-yu Chen and Bangyan L. Stiles -- Section 2 Therapeutic Aspect Including Iron Metabolism and Heparinase in NAFLD -- Chapter 4 Role of the Enzyme Heparanase in the Development of Fatty Liver by Shadi Hamoud -- Chapter 5 Regulation of Iron Metabolism in NAFLD/NASH by Yuki Hamada and Eiichi Hirano -- Chapter 6 Therapeutic Approach to NAFLD-NASH by Georgios Sfikas and Ioannis Valsamidis. 330 $aNon-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis that develops in the absence of competing for liver disease etiologies such as alcohol consumption, monogenic hereditary conditions, or iatrogenic causes. The pathogenesis of NAFLD is multifactorial and its understanding is still incomplete. Although knowledge of the cellular and molecular mechanisms underlying disease development and progression has grown signi?cantly in recent years, the exact contribution of environmental and genetic factors as well as that of extrahepatic and intrahepatic events in determining the disease phenotype remains ill de?ned. This book discusses topics highly correlated with NAFLD such as the regulation of iron metabolism, the role of the enzyme heparanase in liver steatosis, transcriptional regulation by ERR and its role in pathogenesis, hepatic lipid homeostasis, therapeutic approaches to NAFLD, and pathogenesis and significance of HDL as a molecular modifier in NAFLD. 517 $aNon-alcoholic Fatty Liver Disease 606 $aFatty liver 615 0$aFatty liver. 676 $a616.362 702 $aKang$b Ju-Seop 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910647203903321 996 $aNon-alcoholic fatty liver disease$92095512 997 $aUNINA