LEADER 04207nam 22005775 450 001 9910644267503321 005 20251008150444.0 010 $a3-031-18591-9 024 7 $a10.1007/978-3-031-18591-5 035 $a(MiAaPQ)EBC7176575 035 $a(Au-PeEL)EBL7176575 035 $a(CKB)25998100200041 035 $a(DE-He213)978-3-031-18591-5 035 $a(PPN)26781187X 035 $a(EXLCZ)9925998100200041 100 $a20230112d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEndotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care /$fedited by Silvia De Rosa, Gianluca Villa 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (132 pages) 311 08$aPrint version: De Rosa, Silvia Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care Cham : Springer International Publishing AG,c2023 9783031185908 327 $aEndotoxin: Structure Source and Effects -- Pathophysiology of Endotoxic Shock -- Host Resistance to Endotoxic Shock -- Endotoxin and Organ Cross-talk -- Endotoxin Measurement in Septic Shock -- Clinical Management of Endotoxemia: Antibiotics -- Clinical Management of endotoxemia: volume support -- Clinical Management of Endotoxemia: Corticosteroids -- Clinical Management of Endotoxemia: Vasoactive and Cardiostimulant Drugs -- Clinical Management of Endotoxemia: Source Control -- Clinical Management of Endotoxemia: Treatment of DIC -- Clinical Management of Endotoxemia: Metabolic and Nutritional Support -- Strategies to Reduce Endotoxin Activities -- Extracorporeal Removal of Endotoxin. 330 $aThis book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation. The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption. Each section includes ?) brief pathophysiology; ?) principles of management; ?) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the related pathophysiology of endotoxic shock underling the specific clinical aspect and focusing on medical clinical management of endotoxemia and extracorporeal removal. The book ? written by international opinion leaders of this field ? is addressed to healthcare providers working in intensive care and represents a point of reference for intensivists, infectious disease physicians, nephrologists and critical care nurses involved in the management of endotoxic shock and enriched with useful downloadable material. 606 $aInternal medicine 606 $aCritical care medicine 606 $aNephrology 606 $aInternal Medicine 606 $aIntensive Care Medicine 606 $aNephrology 615 0$aInternal medicine. 615 0$aCritical care medicine. 615 0$aNephrology. 615 14$aInternal Medicine. 615 24$aIntensive Care Medicine. 615 24$aNephrology. 676 $a616.025 676 $a616.944 702 $aDe Rosa$b Silvia 702 $aVilla$b Gianluca 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910644267503321 996 $aEndotoxin induced-shock$93364023 997 $aUNINA