LEADER 04957nam 2200613 a 450 001 9910643782903321 005 20230213211645.0 010 $a1-280-76859-2 010 $a9786613679369 010 $a0-470-71920-6 010 $a0-470-71671-1 035 $a(CKB)1000000000687620 035 $a(EBL)703766 035 $a(OCoLC)775867377 035 $a(SSID)ssj0000715101 035 $a(PQKBManifestationID)11410193 035 $a(PQKBTitleCode)TC0000715101 035 $a(PQKBWorkID)10701285 035 $a(PQKB)11568008 035 $a(MiAaPQ)EBC703766 035 $a(EXLCZ)991000000000687620 100 $a19850814h19611960 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCiba Foundation Symposium jointly with Committee for Symposia on Drug Action, on Adrenergic Mechanisms$b[electronic resource] /$feditor for the British Pharmacological Society, J.R. Vane ; editors for the Ciba Foundation, G.E.W. Wolstenholme and Maeve O'Connor 210 $aBoston $cLittle, Brown and Co.$d[1961? c1960] 215 $a1 online resource (666 p.) 225 1 $aCiba Foundation symposia 300 $aDescription based upon print version of record. 311 $a0-470-72264-9 320 $aIncludes bibliographical references and indexes. 327 $aADRENERGIC MECHANISMS; CONTENTS; Opening address; Session 1 : Formafion and lnactivation of Adrenergic Transmitters; Formation of adrenergic transmitters; Formation of adrenaline and noradrenaline; Discussion; The fate of adrenaline and noradrenaline; 3-Methoxy-4-hydroxymandelic acid excretion in phaeochromocytoma; The metabolism of [?-l4CJ](±)-adrenaline in the cat; Discussion; Session 2: Storage of Catechol Aminer; Chairman's opening remarks; Origin, development and distribution of chromaffin cells; The storage of amines in the chromaffin cell 327 $aSome observations on the synthesis and storage of catechol amines in the adrenaline-containing cells of the suprarenal medullaCell types of the adrenal medulla; Discussion; Session 3: The Adrenergic Neurone; Chairman's opening remarks; Release of sympathetic transmitter by nerve stimulation; Discussion; Interference with the release of transmitter in response to nerve stimulation; The effects of bretylium and allied agents on adrenergic neurones; The persistence of adrenergic nerve conduction after TM 10 or bretylium in the cat; Some pharmacological properties of guanethidine; Discussion 327 $aSession 4: Adrenergic Mechanisms in ManEffects of adrenaline, noradrenaline and isopropylnoradrenaline in man; Effects of catechol amines on consecutive vascular sections; Discussion; Clinical effects of drugs which prevent the release of adrenergic transmitter; Bretylium; Discussion; Session 5 : Actions of Adrenaline and Noradrenaline on the Effector Cell; Chairman's opening remarks: The concept of receptors; Relationships between agonists, antagonists and receptor sites; Receptors for sympathomimetic amines; Sympathomimetic drugs and their receptors 327 $aVarious types of receptors for sympathomimetic drugsDiscussion; Biophysical changes produced by adrenaline and noradrenaline; Effect of adrenaline on depolarized smooth muscle; Discussion; The relation of adenosine-3',5'-phosphate to the action of catechol amines; The action of adrenaline on carbohydrate metabolism in relation to some of its pharmacodynamic efficts; Discussion; Session 6: Mechanism of Action of Other Sympathortiimetic Amines; Chairman's opening remarks; Tyramine and other amines as noradrenaline-releasing substances; Some observations on the effects of tyramine; Discussion 327 $aThe actions of sympathomimetic amines on tryptamine receptorsThe depolarizing and blocking action of amphetamine in the cat's superior cervical ganglion; Discussion; Session 7: Central Adrenergic Mechanisms; Chairman's opening remarks; Some central actions of adrenaline and noradrenaline when administered into the cerebral ventricles; Intervention of an adrenergic mechanism during brain stem reticular activation; Electrophysiological evidence relating to the ro?le of adrenaline in the central nervous system; The passage of catechol amines through the blood-brain barrier 327 $aRelease of an adrenaline-like substance by electrical stimulation of the brain stem 410 0$aCiba Foundation symposium. 606 $aAdrenergic mechanisms$vCongresses 615 0$aAdrenergic mechanisms 676 $a612.45082 701 $aVane$b John R$095892 701 $aO'Conner$b Maeve$01275287 701 $aWolstenholme$b G. E. W$g(Gordon Ethelbert Ward)$063039 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910643782903321 996 $aCiba Foundation Symposium jointly with Committee for Symposia on Drug Action, on Adrenergic Mechanisms$93005068 997 $aUNINA