LEADER 03707nam 2200661Ia 450 001 9910642997203321 005 20230213211439.0 010 $a1-282-34585-0 010 $a9786612345852 010 $a0-470-51338-1 010 $a0-470-51339-X 035 $a(CKB)1000000000377195 035 $a(EBL)470561 035 $a(OCoLC)609849517 035 $a(SSID)ssj0000297077 035 $a(PQKBManifestationID)11210007 035 $a(PQKBTitleCode)TC0000297077 035 $a(PQKBWorkID)10327316 035 $a(PQKB)10093247 035 $a(MiAaPQ)EBC470561 035 $a(EXLCZ)991000000000377195 100 $a19860711d1986 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFunctions of the proteoglycans$b[electronic resource] 210 $aChichester ;$aNew York $cWiley$d1986 215 $a1 online resource (311 p.) 225 1 $aCiba Foundation symposium ;$v124 300 $aEditors: David Evered (organizer) and Julie Whelan. 300 $a"Symposium on Functions of the Proteoglycans, held at the Ciba Foundation, London, 14-16 January 1986"--Contents p. [v]. 300 $a"A Wiley-Interscience publication." 311 $a0-471-91090-2 320 $aIncludes bibliographies and indexes. 327 $aFUNCTIONS OF THE PROTEOGLYCANS; Contents; Participants; Introduction; The properties and turnover of hyalu ronan; Cartilage proteog lycans; Biological roles of dermatan sulphate proteog lycans; Common structures of the core proteins of interstitial p rot eog lycans; Biosynthesis and processing of proteodermatan sulphate; ProteogIycan-collagen interactions; The functions of the heparan sulphate proteoglycans; Functions of proteoglycans at the cel surface 327 $aHeparan sulphate proteoglycan as mediator of some adhesive responses and cytoskeletal reorganization of cells on fibronectin matrices: independent versus cooperative functionsGeneral discussion I; Structure and function of basement membrane proteoglycans; Biosynthesis and structure of the basement rnern brane proteoglycan containing he paran sul p hate side-chains; General discussion II; Vascular cel I p roteog lycans: evidence for metabolic modulation; Molecular cloning of proteoglycan core proteins; Secretory granule proteoglycans of mast cells and natural killer cells 327 $aChairman's summing-upIndex of contributors; Subject index 330 $aPresents a comprehensive review of current proteoglycan research, which is providing fresh insights into many major chronic diseases. The proteoglycans are a family of macromolecules which contain one or more glycosaminoglycan chains covalently bound to a core protein. Proteoglycans are a major component of the extracellular matrix of connective tissues and help to determine its volume, resiliency, and organization. They are an important medium through which nutrients, hormones, and other solutes are transported to cells, and they play a significant role in cell-cell interactions. Disturbances 410 0$aCiba Foundation symposium ;$v124. 606 $aProteoglycans$xPhysiological effect$vCongresses 606 $aPhysiology 615 0$aProteoglycans$xPhysiological effect 615 0$aPhysiology. 676 $a574.19245 676 $a612 676 $a612.015754 701 $aEvered$b David$0857127 701 $aWhelan$b Julie$0322651 712 12$aSymposium on Functions of the Proteoglycans$f(1986 :$eCiba Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910642997203321 996 $aFunctions of the proteoglycans$93005959 997 $aUNINA