LEADER 05987nam 2201573z- 450 001 9910639996003321 005 20231214132834.0 010 $a3-0365-6068-8 035 $a(CKB)5470000001633393 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/95858 035 $a(EXLCZ)995470000001633393 100 $a20202301d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNatural and Synthetic Bioactives for Skin Health, Disease and Management 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (314 p.) 311 $a3-0365-6067-X 330 $aIn recent years, researchers have shown a special interest in natural products as alternative methods for the prevention, treatment, and/or management of various skin illnesses and disorders, primarily due to their natural availability, efficacity, reduced cost, and minimal toxicity. In a similar vein, synthetic bioactives, as well as small molecules, have been studied in vitro, in vivo, and in clinical studies as potential drugs or supplements. This Special Issue of Nutrients comprises an array of literature reviews, original communications, and studies on the roles of natural products, synthetic bioactives, and small molecules in a variety of skin disorders and diseases, such as aging, atopic dermatitis, cutaneous T-cell lymphomas, melanoma, allergies, hyperpigmentation, inflammation, and more, which were investigated through in vitro and ex vivo approaches, preclinical trials, cell-based assays, and animal models. The mechanisms of action of certain compounds are proposed, while others are currently under investigation. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of skin disorders, the wealth of information published in this Special Issue can act as a springboard for the development of new preventive and therapeutic modalities for the management of skin diseases. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 610 $akeratinocytes 610 $arutin 610 $aascorbic acid 610 $aUV radiation 610 $aproteomics 610 $a3D cell culture 610 $aborage oil 610 $atriacylglycerol metabolism 610 $aacyl-ceramide 610 $acorneocyte lipid envelope 610 $aepidermis 610 $aanti-melanogenesis 610 $aB16/F10 melanoma cell 610 $ahydroxyoctadecadienoic acid 610 $aSorghum bicolor 610 $a3-isobutyl-1-methylxanthine 610 $amycosis fungoides 610 $aatopic dermatitis 610 $acutaneous lymphomas 610 $acornified envelope proteins 610 $aFLG 610 $amicroalgae 610 $aPlanktochlorella nurekis 610 $askin cells 610 $aproliferation 610 $asenescence 610 $aholothuroids 610 $aglycosaminoglycans 610 $ainflammation 610 $aear-inflammation 610 $awhey 610 $aLactobacillus helveticus 610 $amelanin 610 $a?-melanocyte-stimulating hormone 610 $atyrosinase 610 $atyrosinase-related protein 1 610 $adopachrome tautomerase 610 $amicrophthalmia-associated transcription factor 610 $acosmetics 610 $ablack cumin 610 $aNigella sativa 610 $aThymocid® 610 $askin aging 610 $aglycation 610 $acollagen 610 $acollagenase 610 $aelastase 610 $amelanogenesis 610 $acosmeceutical 610 $akonjac glucomannan 610 $aultraviolet B 610 $ahuman epidermal primary melanocytes 610 $ahuman embryonic fibroblasts 610 $aanti-inflammatory activity 610 $aantioxidant activity 610 $aCornus officinalis 610 $amolecular docking 610 $ahuman high-affinity IgE receptors 610 $a?-MSH 610 $aUVB irradiation 610 $alotus seedpod extract 610 $aepigallocatechin 610 $apropolis 610 $askin 610 $amatrix metalloproteinase-1 610 $aUV 610 $aphosphoinositide 3-kinase 610 $askin care 610 $askin health 610 $abioactive substances 610 $aphytonutrients 610 $aantioxidants 610 $anutraceuticals 610 $aPerilla frutescens 610 $acell proliferation 610 $aultraviolet radiation 610 $aDNA repair 610 $aLactobacillus plantarum CJLP55 610 $aacne vulgaris 610 $asebum 610 $ahydration 610 $aurine bacterial extracellular vesicles 610 $afungal infections 610 $ananohydrogel 610 $apolysaccharide 610 $aessential oils 610 $aeggshell membrane 610 $akeratinocyte differentiation 610 $aTRPV 610 $askin thickness 610 $aLithospermum erythrorhizon 610 $aNC/Nga 610 $aTh1 610 $aTh2 610 $aTh17 610 $aTh22 610 $aimmune balance 610 $askin barrier function 615 7$aResearch & information: general 615 7$aBiology, life sciences 700 $aChamcheu$b Jean Christopher$4edt$01278483 702 $aWalker$b Anthony L$4edt 702 $aNoubissi-Kamdem$b Felicite$4edt 702 $aChamcheu$b Jean Christopher$4oth 702 $aWalker$b Anthony L$4oth 702 $aNoubissi-Kamdem$b Felicite$4oth 906 $aBOOK 912 $a9910639996003321 996 $aNatural and Synthetic Bioactives for Skin Health, Disease and Management$93013407 997 $aUNINA LEADER 07734nam 22006491c 450 001 9910784725003321 005 20200115203623.0 010 $a1-4725-6403-0 010 $a1-281-25865-2 010 $a9786611258658 010 $a1-84731-375-2 024 7 $a10.5040/9781472564030 035 $a(CKB)1000000000405918 035 $a(EBL)335266 035 $a(OCoLC)476147021 035 $a(SSID)ssj0000152988 035 $a(PQKBManifestationID)12007750 035 $a(PQKBTitleCode)TC0000152988 035 $a(PQKBWorkID)10391679 035 $a(PQKB)10564402 035 $a(MiAaPQ)EBC1772413 035 $a(MiAaPQ)EBC335266 035 $a(OCoLC)232574854 035 $a(UtOrBLW)bpp09256151 035 $a(Au-PeEL)EBL335266 035 $a(EXLCZ)991000000000405918 100 $a20140929d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFair trials $ethe European criminal procedural tradition and the European Court of Human Rights $fSarah J. Summers 205 $a1st ed. 210 1$aOxford $aPortland, Oregon $cHart Publishing $d2007. 215 $a1 online resource (209 p.) 225 1 $aCriminal law library $vv. 4 300 $aDescription based upon print version of record. 311 $a1-84113-730-8 320 $aIncludes bibliographical references and index 327 $aPart One -- 1. The Enduring Legacy of 'Inquisitorial' and 'Accusatorial' Procedural Forms in the Debate on Comparative Criminal Procedure -- AThe Enduring Legacy of the Inquisitorial -- Accusatorial Divide -- BThe Connection to Legal Nationalism -- CDeveloping a New Approach for Analysing European Criminal Procedure Law -- 2. The Origins of the European Criminal Procedural Tradition -- AIntroduction: The Importance of the Developments of the Nineteenth Century -- BThe Development of the 'Accusatorial Trinity' -- CJudicial Impartiality -- (i)The Separation of the Functions of 'Judging' and Prosecuting in -- France and Germany -- (ii) Impassivity or Activity: The Role of the English Judge in the -- Examination of the Evidence -- (iii) Institutional Impartiality -- DThe Public Hearing Requirement -- EImmediate and Oral Proceedings -- (i) Immediate and Oral Examination of Evidence at Trial -- (ii) Consideration at Trial of Evidence Collected before the Trial and -- Submitted in Writing -- (iii)Immediate and Oral Proceedings as Fundamental to the Accusatorial -- System -- FConclusions -- 3. The Rights of the Defence: Lessons from the Nineteenth Century -- AThe Institutional Nature of the 'Rights of the Accused' -- BThe Rights of the Defence at Trial -- (i)The Presence of the Accused -- (ii) Participatory Rights of the Accused -- (a) The Developing Conception of the Accused as a Party -- (b) Understanding the Nature of the Accused's Participatory Rights: The English Reforms of the Late Nineteenth Century -- (c) The Assistance of Counsel -- CThe Role of the Defence in the Pre-trial Phase -- (i) The Pre-trial Phase as 'Investigative' -- (a) The Questioning of the Accused -- (b) The Examination of Evidence -- (ii)The Determinative Reality of the Investigation -- DConclusions -- Part Two -- 4. Defining Fairness in Article 6(1) ECHR -- AIntroduction -- BIdentifying Vargha's 'Accusatorial Trinity' -- CThe Role of the 'Equality of Arms' Doctrine -- DThe Relationship between the Adversarial Procedure Requirement and the -- Equality of Arms -- EThe Court's Interpretation of the Adversarial Procedure Requirement in -- Criminal Proceedings -- (i)The Right to be Present at Trial -- (ii)Knowledge of the Other Side's Submissions -- (iii)Opportunity to Comment on the Other Side's Submissions -- FThe Relationship between the Defence and the Prosecution -- GFairness and Implied Procedural Forms -- 5. The Structure of the 'Trial' in Article 6 ECHR -- AIntroduction -- BThe Defence's Right to Challenge Witness Evidence -- CWitness Evidence in Europe: An Overview -- DRegulating Witness Evidence: Article 6(3)(d) -- (i)What is an Adequate and Proper Opportunity to Challenge Witnesses? -- (a) The Identity of the Witness -- (b) The Importance of the Witness -- (ii)When Should Witnesses be Examined? -- EThe Importance of the Trial as the Forum for Confronting Witness Evidence -- FReconciling Examination of Witnesses in the Investigation Phase with the -- 'Accusatorial Trinity' -- (i)The Presence of Counsel during Pre-trial Examination of Witnesses -- (ii)The Presence of an Impartial Supervisory Authority during the Examination of Witnesses -- (iii)Immediacy -- G The Privilege Against Self-incrimination -- (i) Improper Compulsion -- (ii) Indirect 'Acceptable' Compulsion -- (iii) The Relationship between Compulsion and the Assistance of Counsel -- (iv) The Privilege against Self-incrimination as a Substitute for the Refusal to Insist on Adversarial Principles in the Investigation Phase -- HThe Root of the Problem: Defining the 'Trial' -- (i)The Investigation Phase Lacuna -- (ii)Explaining the Investigation Phase Lacuna: Les Travaux Pre?paratoires -- (iii)Resolving the Fairness Deficit: Acknowledging the European Procedural Tradition -- 6. Reassessing Fairness in European Criminal Law: Procedural Fairness, Defence Rights and Institutional Forms -- AProcedural Fairness as Individual Rights -- BProcedural Rights and Institutional Forms -- CArticle 6 ECHR and the European Criminal Procedural Tradition -- DTowards an Institutional Understanding of Fairness in Criminal Proceedings 330 8 $aThe right to a fair trial has become an issue of increasing public concern, following a series of high profile cases such as the Bulger case, Khan (Sultan) and R v DPP ex p Kebilene. In determining the scope of the right, we now increasingly look to the ECHR, but the court has given little guidance, focusing on reconciling procedural rules rather than addressing the broader issues. This book addresses the issue of the meaning of the right by examining the contemporary jurisprudence in the light of a body of historical literature which discusses criminal procedure in a European context. It argues that there is in fact a European criminal procedural tradition which has been neglected in contemporary discussions, and that an understanding of this tradition might illuminate the discussion of fair trial in the contemporary jurisprudence. This challenging new work elucidates the meaning of the fair trial and in doing so challenges the conventional approach to the analysis of criminal procedure as based on the distinction between adversarial and inquisitorial procedural systems. The book is divided into two parts. The first part is dominated by an examination of the fair trial principles in the works of several notable European jurists of the nineteenth century, arguing that their writings were instrumental in the development of the principles underlying the modern conception of criminal proceedings. The second part looks at the fair trials jurisprudence of the ECHR and it is suggested that although the Court has neglected the European tradition, the jurisprudence has nevertheless been influenced, albeit unconsciously, by the institutional principles developed in the nineteenth century 410 0$aCriminal law library (Oxford, England)$vv. 4. 606 $aFair trial$zEurope 606 $2International criminal law 606 $aCriminal procedure$zEurope 615 0$aFair trial 615 0$aCriminal procedure 676 $a345.4056 700 $aSummers$b Sarah J.$0725316 801 0$bUtOrBLW 801 1$bUtOrBLW 801 2$bUkLoBP 906 $aBOOK 912 $a9910784725003321 996 $aFair trials$93832943 997 $aUNINA