LEADER 04394nam 22006615 450 001 9910639877503321 005 20251008152006.0 010 $a3-031-20025-X 024 7 $a10.1007/978-3-031-20025-0 035 $a(MiAaPQ)EBC7165772 035 $a(Au-PeEL)EBL7165772 035 $a(CKB)25913872000041 035 $a(PPN)267817142 035 $a(DE-He213)978-3-031-20025-0 035 $a(OCoLC)1362528079 035 $a(EXLCZ)9925913872000041 100 $a20221221d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRevising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept /$fby Panos Macheras, Athanasios A. Tsekouras 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (137 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$aPrint version: Macheras, Panos Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept Cham : Springer International Publishing AG,c2023 9783031200243 320 $aIncludes bibliographical references. 327 $aPart I: Oral Pharmacokinetics -- Chapter 1. From Bateman (1908) To Dost (1953) -- Chapter 2. The Unphysical Hypothesis Of Infinite Absorption Time -- Chapter 3. The Finite Absorption Time (Fat) Concept -- Chapter 4. The Rise Of Physiologically Based Finite Time Pharmacokinetic (Pbftpk) Models -- Part II: Bioavailability-Bioequivalence -- Chapter 5. History Of The Bioavailability-Bioequivalence Concepts -- Chapter 6. Therapeutic Equivalence Based On Bioequivalence Studies -- Chapter 7. Bioavailability Under The Prism Of Finite Absorption Time -- Chapter 8. Bioequivalence Under The Prism Of Finite Absorption Time. 330 $aThis book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering. This excellent text serves as a historical review of drug absorption kinetics and its application to bioavailability and bioequivalence. However, its main thrust is the application of the authors' innovative new approaches to modifying these processes utilizing concepts of finite absorption time (FAT) and physiologically based finite time pharmacokinetic (PBFTPK) models. The work described in detail is based on the innovative experimental studies, many in depth examples and simulations, and the authors' outstanding theoretical contributions to our understanding of drug gastrointestinal absorption, and drug pharmacokinetics. I found the book to be an enjoyable and enlightening read. Professor Leslie Benet, Department of Bioengineering & Therapeutic Sciences, Schools of Pharmacy & Medicine, University of California, San Francisco, USA. 410 0$aBiomedical and Life Sciences Series 606 $aPharmaceutical chemistry 606 $aPharmacology 606 $aPharmacy 606 $aBiomedical engineering 606 $aPharmaceutics 606 $aPharmacology 606 $aPharmacy 606 $aBiomedical Engineering and Bioengineering 615 0$aPharmaceutical chemistry. 615 0$aPharmacology. 615 0$aPharmacy. 615 0$aBiomedical engineering. 615 14$aPharmaceutics. 615 24$aPharmacology. 615 24$aPharmacy. 615 24$aBiomedical Engineering and Bioengineering. 676 $a615.7 700 $aMacheras$b P$g(Panos),$01351088 702 $aTsekouras$b Athanasios A. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910639877503321 996 $aRevising oral pharmacokinetics, bioavailability and bioequivalence based on the finite absorption time concept$93090580 997 $aUNINA