LEADER 00921nam0-22003371i-450- 001 990003783660403321 005 20001010 010 $a88-204-0008-1 035 $a000378366 035 $aFED01000378366 035 $a(Aleph)000378366FED01 035 $a000378366 100 $a20001010d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aALIENAZIONE e sociologia$fscritti di D. Bell, J. P. Clark...[et al.]$ga cura di Alberto Izzo 205 $a2.ed. 210 $aMilano$cFranco Angeli$d1980 215 $a344 p.$d22 cm 225 1 $aCollana di sociologia$v13 610 0 $aALIENAZIONE 676 $a302.544 702 1$aIzzo,$bAlberto$f<1933- > 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990003783660403321 952 $a302.544 IZZ 2$b2226$fBFS 959 $aBFS 996 $aAlienazione e sociologia$9273851 997 $aUNINA DB $aING01 LEADER 00813nam0-2200265 --450 001 9910635995903321 005 20230112181053.0 017 70$a448273$2U 020 $aIT$b1897 8811 100 $a20230112d1898----kmuy0itay5050 ba 101 0 $aita 102 $aIT 105 $a 001yy 200 1 $a<>lunedi nella scuola$econversazioni sui doveri e sui diritti$elibro per le scuole femminili e per le famiglie$fMaria Cleofe Pellegrini 205 $a2. ed. riveduta e corretta 210 $aMilano$cG. Agnelli$d1898 215 $aVI, 308 p.$d19 cm 700 1$aPellegrini,$bMaria Cleofe$0617533 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910635995903321 952 $a5/XII C 40$binv.124$fFLFBC 959 $aFLFBC 996 $aLunedi nella scuola$92998261 997 $aUNINA LEADER 10895nam 2200493 450 001 9910829981303321 005 20230415163825.0 010 $a1-119-78974-5 010 $a1-119-78972-9 035 $a(MiAaPQ)EBC7155925 035 $a(Au-PeEL)EBL7155925 035 $a(CKB)25657498800041 035 $a(EXLCZ)9925657498800041 100 $a20230415d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCoronavirus disease 2019 (COVID-19) $ea clinical guide /$fAli Gholamrezanezhad and Michael P. Dube 210 1$aHoboken, NJ :$cJohn Wiley & Sons, Inc.,$d[2023] 210 4$d©2023 215 $a1 online resource (701 pages) 311 08$aPrint version: Gholamrezanezhad, Ali Coronavirus Disease 2019 (Covid-19) Newark : John Wiley & Sons, Incorporated,c2023 9781119789680 327 $aCover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- Chapter 1 COVID-19: Epidemiology -- Origin -- Animal Host -- Infectivity and Incubation -- Modes of Transmission -- Overview -- Respiratory Droplets -- Aerosolization -- Direct Surface Contact and Fomites -- Fecal-Oral -- Bloodborne -- Semen and Vaginal Secretions -- Asymptomatic Transmission -- Virulence and Mortality -- Case Fatality Rate -- Serial Interval -- Reproduction Number/Reproduction Ratio -- Excess Mortality -- Demographics -- Overview -- Age -- Sex -- Race and Ethnicity -- Disease Prevention -- Vaccinations -- Personal Protective Equipment: Respirators and Masks -- Physical Distancing -- Hand and Surface Sanitation -- Adequate Ventilation of Indoor Spaces -- Use of Outdoor Spaces -- Global Impacts -- Distribution -- International Response -- Future Outbreaks -- Conclusions -- References -- Chapter 2 COVID-19: Virology -- Coronaviruses -- Taxonomy -- Morphology -- Nucleic Acid -- Antigenicity -- SARS-CoV-2 -- Morphology and Nucleic Acid -- Spike Protein -- Origin -- Viral Transmission -- Variants -- References -- Chapter 3 COVID-19: Laboratory/Serologic Diagnostics -- Molecular Diagnostics for COVID-19 -- Nucleic Acid Amplification Testing -- RT-qPCR -- RT-LAMP -- CRISPR-Based Techniques -- Sequencing Techniques -- Antigen Testing -- Viral Culture -- Antibody Testing for COVID-19 -- Principles of Antibody Testing -- Antibody Assays for SARS-CoV-2 -- Assay Target Selection -- Binding Assays -- Neutralization Assays -- Antibody Assay Sensitivity and Specificity -- Humoral Response to SARS-CoV-2 Infection -- Kinetics of Antibody Response -- Antibody Response and Disease Severity -- Duration of Immunity -- Current and Potential Applications of Antibody-Based Tests in SARS-CoV-2 -- Management of Individual Disease and Sequelae Monitoring. 327 $aContact Tracing -- Vaccine Efficacy -- Conclusions and Future Directions -- References -- Chapter 4 COVID-19: Radiologic Diagnosis -- Current Guidelines on When to Image -- Fleischner Society -- World Health Organization -- Practical Points -- Technical Considerations to Limit Spread While Imaging -- Chest Radiography -- Cross-Sectional Imaging -- Ultrasound -- Imaging by Modality -- X-Ray -- Computed Tomography -- Ultrasound -- PET -- MRI -- Guidelines for Reporting -- RSNA -- COVID-19 Reporting and Data System -- COVID-19 Imaging Reporting and Data System -- References -- Chapter 5 COVID-19: Pathology Perspective -- Gross and Histopathologic Findings in the Respiratory System -- Gross and Histopathologic Findings in the Cardiovascular System -- Histopathologic Findings in Kidney -- Histopathologic Findings in the Gastrointestinal Tract and Liver -- Histopathologic Findings in Brain -- Histopathologic Findings in Skin -- References -- Chapter 6 COVID-19: Immunology -- Anatomic Progression of COVID-19 -- Adaptive Immune Response in the Nasal Passages and the Lungs -- Immune Response to Immunization -- Immune Correlates of Protection from Infection -- Decline in Vaccine-Induced Immune Responses over Time -- Immune Consequences of Virologic Dissemination -- Autoantibodies Against Type I IFN -- Viral Evasion -- Immune Dysregulation -- Antibody-Dependent Cellular Cytotoxicity -- Cytokine Storm -- Conclusions -- Acknowledgments -- References -- Chapter 7 COVID-19: Presentation and Symptomatology -- Pulmonary Manifestations of COVID-19 -- Atypical Acute Respiratory Distress Syndrome -- Otolaryngologic Manifestations of COVID-19 -- Sense of Smell -- Voice Disorders -- Hearing, Tinnitus, and Facial Nerve -- Gastrointestinal Manifestation of COVID-19 -- Coronavirus and Pregnancy -- Physiologic Changes and Effect of SARS-CoV-2 Infection. 327 $aGeneral Symptoms of COVID-19 in Obstetric Patients -- Impact of COVID-19 on Gestation: Maternal and Neonatal Outcomes -- Vertical Transmission and Possible Fetal Complications -- COVID-19 and Delivery -- Breastfeeding -- Vaccination -- Urologic Manifestations of COVID-19 -- Kidneys -- Genital and Lower Urinary Tract Infection -- Disorders of Genital Organ Function -- Infertility -- References -- Chapter 8 COVID-19: Risk Stratification -- Potential Biomarkers for COVID-19 Detection, Severity, and Mortality -- Host Risk Factors for COVID-19 -- ABO Blood Type as an Additional Risk Factor -- ABO Blood Group and Rh Factor -- Association of Blood Group with Viral Respiratory Diseases -- Association of Blood Type with Higher Susceptibility to COVID-19 Infection and Outcomes -- Genetic Association and Underlying Molecular Mechanisms -- ML Methods for X-Ray and CT Image Classification and Prediction -- References -- Chapter 9 COVID-19: Outpatient Management in Adults -- Potential Conflicts of Interest -- Initial Diagnosis -- Prognosis and Choice of Admission Versus Outpatient Management -- Home Monitoring -- Telehealth Diagnosis and Follow-up -- Pulse Oximetry Monitoring -- Post-Hospital Discharge Care -- General Management Issues -- Isolation -- Hydration and Nutrition -- Continuation of Ongoing Therapies -- Nutritional Supplements -- Anticoagulation -- Use of Home Supplemental Oxygen -- Antivirals and Anti-inflammatory Treatments -- Anti-SARS-CoV-2 mAbs -- Selection of Outpatients to Receive Anti-SARS-CoV-2 mAbs -- Bamlanivimab Plus Etesevimab -- Casirivimab Plus Imdevimab -- Sotrovimab -- Bebtelovimab -- Side Effects of Anti-SARS-CoV-2 mAbs -- Distribution of mAbs -- Oral Antivirals -- Molnupiravir -- Nirmatrelvir (PF-07321332)/Ritonavir -- Outpatient Anti-inflammatory Interventions -- Inhaled Budesonide -- Fluvoxamine -- Dexamethasone. 327 $aDrugs That Are Not Recommended for Outpatient Use -- Janus Kinase Inhibitors/Anti-IL-6 Therapies -- Chloroquine and Hydroxychloroquine -- Ivermectin -- Azithromycin -- Lopinavir/Ritonavir -- Convalescent Plasma -- Colchicine -- Summary -- References -- Chapter 10 COVID-19: Inpatient Management -- Respiratory Support for Hospitalized Patients with COVID-19 -- Noninvasive Respiratory Support -- Prone Positioning in Awake Patients -- Caring for the Critically Ill Patient with COVID-19 -- Practical Considerations for Intubating Patients -- Mechanical Ventilation of Patients with COVID-19 -- Rescue Therapies for Refractory Hypoxemia of Ventilated Patients -- Pharmacologic Therapies for Hospitalized Patients with COVID-19 -- Use of Antivirals in Patients Hospitalized for COVID-19 -- Anti-inflammatory Therapies for Hospitalized Patients with COVID-19 -- Therapies that Have No Benefit in Hospitalized Patients with COVID-19 -- Extrapulmonary Disease in Acutely Ill Patients with COVID-19 -- Thromboembolic Disease -- Cardiac Complications -- Renal Complications -- Infectious Complications -- Performing Aerosol-Generating Procedures in Patients with COVID-19 -- Bronchoscopy in COVID-19 -- Tracheostomy in Patients with COVID-19 -- Cardiopulmonary Resuscitation of the Patient with COVID-19 -- Coordinating Patient Placement and Care in COVID-19 Units -- Increasing ICU Capacity -- Additional Management Considerations -- References -- Chapter 11 COVID-19: ICU and Critical Care Management -- Epidemiology of Critically Ill Patients with COVID-19 Pneumonia -- Risk Factors for Severe Disease -- Mortality -- Infection Prevention and Control of COVID-19 in the ICU -- Aerosol-Generating Procedures -- Visitation -- Cardiopulmonary Resuscitation in COVID-19 -- Hemodynamic Support in COVID-19 -- Management of Respiratory Failure from COVID-19 -- Intubation. 327 $aVentilator Management -- Prone Positioning -- Treatment of COVID-19-Associated ARDS with Corticosteroids -- Tocilizumab for Critical COVID-19 Illness -- Extracorporeal Membrane Oxygenation for COVID-19 ARDS -- Venous Thromboembolism and Anticoagulation in COVID-19 -- After the ICU: Challenges for Survivors of COVID-19 Critical Illness -- References -- Chapter 12 COVID-19 in Pediatrics -- Epidemiology -- Epidemiology of Multisystem Inflammatory Syndrome in Children -- Transmission in Children -- Neonatal Transmission -- Breastfeeding -- Clinical Manifestations -- Disease Severity -- Infection in Infants (Age < -- 1 Year) -- Cutaneous Manifestations -- COVID Toes -- Neurologic Symptoms -- Atypical Clinical Manifestations -- Imaging Findings -- MIS-C Clinical Manifestations -- Post-Acute Sequelae of SARS-CoV-2 (PASC) in Children -- Approach to Diagnosis -- Screening and Diagnosis in Symptomatic Patients -- Screening and Diagnosis in Asymptomatic Patients -- Neonatal Testing -- COVID-Recovered Patients -- Retesting of COVID-Recovered Patients -- Testing of COVID-19 Fully Vaccinated Persons -- MIS-C Diagnosis -- Hyperinflammation in COVID-19 Versus MIS-C -- Management -- Outpatient Management -- Inpatient Management -- Special Populations -- Antiviral Therapy -- Glucocorticoids -- Nonsteroidal Anti-inflammatory Drugs -- Convalescent Plasma -- Adjunctive Therapy -- Kinase Inhibitors -- Superimposed Infections -- Management of MIS-C -- Guidance for Return to Sports After SARS-CoV-2 Infection -- Vaccines -- References -- Chapter 13 Pharmacologic Therapeutics for COVID-19 -- Virus Life Cycle -- Drug Development for SARS-CoV-2 -- Immune Responses that Contribute to COVID-19 Pathology -- Challenges to Discover and Deploy Drugs for a New Infectious Agent -- Therapeutic Classes -- Antivirals -- Camostat (Foipan) -- Nafamostat -- Upamostat. 327 $aChloroquine and Hydroxychloroquine. 606 $aCOVID-19 (Disease) 606 $aCOVID-19 (Disease)$xPrevention 615 0$aCOVID-19 (Disease) 615 0$aCOVID-19 (Disease)$xPrevention. 676 $a362.1962414 700 $aGholamrezanezhad$b Ali$01659685 702 $aDube$b Michael P. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910829981303321 996 $aCoronavirus disease 2019 (COVID-19)$94014451 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