LEADER 04664nam 22007815 450 001 9910635397603321 005 20240311094916.0 010 $a9783031208485$b(electronic bk.) 010 $z9783031208478 024 7 $a10.1007/978-3-031-20848-5 035 $a(MiAaPQ)EBC7158323 035 $a(Au-PeEL)EBL7158323 035 $a(CKB)25732554700041 035 $a(DE-He213)978-3-031-20848-5 035 $a(EXLCZ)9925732554700041 100 $a20221216d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe Centrosome and its Functions and Dysfunctions /$fby Heide Schatten 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (115 pages) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v235 311 08$aPrint version: Schatten, Heide The Centrosome and Its Functions and Dysfunctions Cham : Springer International Publishing AG,c2023 9783031208478 320 $aIncludes bibliographical references and index. 327 $aCell and Molecular Biology of Centrosome Structure and Function -- The centrosome Cycle within the cell cycle -- Centrosome as center for proteolytic activity and dysfunctions associated with pathogenesis of human disease -- Centrosome dysfunctions in cancer -- Virus exploitation of centrosomes -- Centrosomes in reproduction -- Transition from centrosomal to non-centrosomal microtubule organization during cellular polarization -- External and environmental effects on Centrosomes -- Centrosomes and centrosome equivalents in other systems -- Non-centrosomal microtubule organization in plant cells. 330 $aThe book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research. . 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v235 606 $aCytology 606 $aReproduction 606 $aPhysiology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aCancer 606 $aDevelopmental biology 606 $aCell Biology 606 $aReproductive Physiology 606 $aBiomedical Research 606 $aCancer Biology 606 $aDevelopmental Biology and Stem Cells 606 $aCentrosomes$2thub 606 $aCitologia$2thub 608 $aLlibres electrònics$2thub 615 0$aCytology. 615 0$aReproduction. 615 0$aPhysiology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aCancer. 615 0$aDevelopmental biology. 615 14$aCell Biology. 615 24$aReproductive Physiology. 615 24$aBiomedical Research. 615 24$aCancer Biology. 615 24$aDevelopmental Biology and Stem Cells. 615 7$aCentrosomes 615 7$aCitologia 676 $a574.3 700 $aSchatten$b Heide$0899576 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910635397603321 996 $aThe Centrosome and Its Functions and Dysfunctions$92998106 997 $aUNINA