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010   $a9789811978142$b(electronic bk.)
010   $z9789811978135
024 7 $a10.1007/978-981-19-7814-2
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035   $a(Au-PeEL)EBL7157444
035   $a(CKB)25703758000041
035   $a(DE-He213)978-981-19-7814-2
035   $a(OCoLC)1355218110
035   $a(EXLCZ)9925703758000041
100   $a20221213d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDiscovery of Small-Molecule Modulators of Protein?RNA Interactions for Treating Cancer and COVID-19 /$fby Wan Gi Byun
205   $a1st ed. 2023.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023.
215   $a1 online resource (156 pages)
225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061
300   $a"Doctoral thesis accepted by Seoul National University, Seoul, Korea (Republic of)"
311 08$aPrint version: Byun, Wan Gi Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and COVID-19 Singapore : Springer,c2022 9789811978135 
327   $a1. Introduction -- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28?Let-7 Interaction -- 3. Discovery of Small-Molecule Modulators of Protein?RNA Interactions by Fluorescence Intensity-Based Binding Assay -- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2 -- Appendix.
330   $aThis book describes the development of novel protein?RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein?RNA interactions to treat cancer and COVID-19. Modulating protein?RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein?RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein?RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein?RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein?RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein?RNA interactions in chemical biology and drug development.
410  0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061
606   $aBioengineering
606   $aBiotechnology
606   $aBiophysics
606   $aProtein folding
606   $aRNA interference
606   $aBiological and Physical Engineering
606   $aChemical Bioengineering
606   $aBiophysics
606   $aProtein Folding
606   $aRNA Interference
615  0$aBioengineering.
615  0$aBiotechnology.
615  0$aBiophysics.
615  0$aProtein folding.
615  0$aRNA interference.
615 14$aBiological and Physical Engineering.
615 24$aChemical Bioengineering.
615 24$aBiophysics.
615 24$aProtein Folding.
615 24$aRNA Interference.
676   $a362.1962414
700   $aByun$b Wan Gi$01272792
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910635394703321
996   $aDiscovery of Small-Molecule Modulators of Protein?RNA Interactions for Treating Cancer and COVID-19$94164333
997   $aUNINA