LEADER 10810nam 2200493 450 001 9910635383403321 005 20231110212941.0 010 $a9789811972683$b(electronic bk.) 010 $z9789811972676 035 $a(MiAaPQ)EBC7157440 035 $a(Au-PeEL)EBL7157440 035 $a(CKB)25703671000041 035 $a(EXLCZ)9925703671000041 100 $a20230418d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDorsolateral prefrontal cortex $eworking memory and executive functions /$fShintaro Funahashi 210 1$aSingapore :$cSpringer,$d[2022] 210 4$d©2022 215 $a1 online resource (554 pages) 225 1 $aBrain Science 311 08$aPrint version: Funahashi, Shintaro Dorsolateral Prefrontal Cortex Singapore : Springer,c2022 9789811972676 327 $aIntro -- Preface -- Acknowledgments -- Contents -- Chapter 1: Dorsolateral Prefrontal Cortex -- 1.1 Introduction -- 1.2 The Prefrontal Cortex -- 1.3 Features of the Prefrontal Cortex -- 1.4 Anatomical Features of the Prefrontal Cortex -- 1.4.1 Cytoarchitectonic Features -- 1.4.2 Cytoarchitectonic Features of the Lateral Prefrontal Cortex -- 1.4.3 Relations to the Thalamic Mediodorsal Nucleus -- 1.4.4 Granular Layer IV -- 1.4.5 Mesulam´s Cortical Classification -- 1.5 Anatomical Features of the Lateral Prefrontal Cortex -- 1.5.1 Cellular Components -- 1.5.1.1 Pyramidal Neurons -- 1.5.1.2 Nonpyramidal Neurons -- 1.5.1.3 Interactions Between Pyramidal and Nonpyramidal Neurons -- 1.5.1.4 Modulation of Activity by Catecholamine and Monoamine -- 1.5.2 Anatomical Heterogeneity in Area 46 -- 1.5.3 Cortico-Cortical Connections -- 1.5.3.1 Afferent Connections -- 1.5.3.2 Efferent Connections -- 1.5.3.3 Callosal Connections -- 1.5.4 Cortico-Subcortical Connections -- 1.5.4.1 Anatomical Connections with the Thalamus -- 1.5.4.2 Prefrontal Connections with the Basal Ganglia -- 1.5.4.3 Prefrontal Connections with Other Subcortical Structures -- 1.5.5 Intracortical Structures: Columnar Organization -- 1.6 Functional Features of the Lateral Prefrontal Cortex -- 1.6.1 Human Prefrontal Functions -- 1.6.2 Functional Heterogeneity of the Prefrontal Cortex -- 1.6.3 Functional Heterogeneity in Human Prefrontal Cortex -- 1.6.4 Functional Development of the Prefrontal Cortex -- References -- Chapter 2: Historical Perspective of Prefrontal Research -- 2.1 Functional Localization of the Cerebral Cortex -- 2.2 Historical Perspective of Frontal Lobe Functions -- 2.2.1 Debate Between Holistic Theory and Localization Theory -- 2.2.2 Functions of the Frontal Lobe -- 2.2.3 Lashley´s Principles: Equipotentiality and Mass Action. 327 $a2.2.4 The Prefrontal Cortex Has Some Specific Function -- 2.2.5 Jacobsen´s Experiments Using Delayed-Response Task -- 2.2.6 Delayed-Response Deficits Caused by Prefrontal Lesions -- 2.2.7 Localization of the Cortical Area Responsible for Delayed-Response Performance -- 2.2.8 Delayed-Response Deficits Can Be Observed in Human Prefrontal Patients -- 2.2.9 Delayed-Response Deficits Can Also Be Observed in Rats and Dogs -- 2.3 Behavioral Deficits in Other Delay Tasks Caused by Prefrontal Lesions -- 2.3.1 Delayed Alternation Task and Importance of Spatial Factor -- 2.3.2 Delayed Matching-to-Sample Task and Other Delay Tasks -- 2.4 Cryogenic Depression of Prefrontal Functions -- 2.5 What Causes Delayed-Response Deficits? -- 2.5.1 Factors Affecting Delayed-Response Performances -- 2.5.2 Increased Susceptibility, Distractibility, and Hyperactivity to Irrelevant Stimuli -- 2.5.3 Kinesthetic Effects -- 2.6 Mnemonic Hypothesis of Prefrontal Function -- 2.6.1 Problems of Behavior Control During the Delay Period -- 2.6.2 An Oculomotor Version of the Delayed-Response Task -- 2.6.3 Mnemonic Scotoma Observed in Prefrontal Lesioned Monkeys -- 2.6.4 Contralateral Bias of Spatial Mnemonic Process in the Prefrontal Cortex -- 2.6.5 Working Memory Is an Important Function of the Prefrontal Cortex -- References -- Chapter 3: Working Memory and Prefrontal Functions -- 3.1 Introduction -- 3.2 Short-Term Memory and Working Memory -- 3.2.1 Modal Model of Human Memory -- 3.2.2 Baddeley and Hitch´s Experiment -- 3.3 Working Memory -- 3.3.1 Working Memory Model Proposed by Baddeley -- 3.3.2 Other Models and Definitions of Working Memory -- 3.3.3 Working Memory in Animal Studies -- 3.3.3.1 Working Memory Versus Reference Memory -- 3.3.3.2 Spatial Working Memory Tasks -- 3.3.3.3 Non-spatial Working Memory Tasks and Recognition Memory Tasks. 327 $a3.3.4 Advantages of Delayed-Response Task in Searching Neural Mechanisms of Working Memory -- 3.3.5 Working Memory As an Important Concept for Prefrontal Functions -- 3.4 Working Memory in the Prefrontal Cortex -- 3.4.1 Search for Neural Correlates of Working Memory in the Prefrontal Cortex -- 3.4.2 Kubota´s and Fuster´s Studies in the Prefrontal Cortex -- 3.4.3 Differential Delay-Period Activity. -- 3.4.4 Delay-Period Activity Is a Neural Correlate of the Mnemonic Process in the Prefrontal Cortex? -- 3.4.5 Differential Delay-Period Activity As a Neural Correlate of Mnemonic Process? -- 3.5 An oculomotor Delayed-Response Task -- 3.5.1 The Oculomotor Delayed-Response Task -- 3.5.2 Task-Related Prefrontal Activity in the ODR Task -- 3.6 Delay-Period Activity in the ODR Task -- 3.6.1 Sustained Nature of Delay-Period Activity -- 3.6.2 Directional Selectivity -- 3.6.3 Robustness of Delay-Period Activity -- 3.6.4 Learning Effects -- 3.6.5 Delay-Period Activity Is a Neural Correlate of Working Memory Process -- 3.6.6 Mnemonic Receptive Field -- 3.6.7 Delay-Period Activity Represents Retrospective and Prospective Information -- 3.6.8 Delay-Period Activity Represents Relative or Absolute Spatial Information -- 3.7 Delay-Period Activity Encoding Non-spatial Visual Information -- 3.7.1 Delay-Period Activity in Non-spatial Visual Working Memory Tasks -- 3.7.2 Delay-Period Activity Representing Object Categories. -- 3.7.3 Robustness of Delay-Period Activity -- 3.7.4 Retrospective Coding Versus Prospective Coding -- 3.7.5 Interactions Between Spatial and Non-spatial Information -- 3.8 Delay-Period Activity Encoding Somatosensory Information -- 3.9 Delay-Period Activity Representing Motor Information -- 3.10 Delay-Period Activity Representing Task Difference and Behavioral Rule -- 3.11 Delay-Period Activity Representing Reward Expectation. 327 $a3.12 Delay-Period Activity Representing Temporal Order of Stimulus Presentation -- 3.13 Delay-Period Activity Representing Numerical Quantity -- 3.14 Delay-Period Activity Representing Relative Distance Between Stimuli -- 3.15 Delay-Period Activity Representing Estimation of Behavioral Timing -- 3.16 Information Processing in Working Memory -- 3.16.1 Information Represented by Delay-Period Activity Changes -- 3.16.2 Population-Vector Analysis -- 3.16.3 Population-Vector Analysis of Delay-Period Activity -- 3.16.4 What Causes the Rotation of the Population Vector during the Delay Period? -- 3.16.5 Interaction Between Delay-Period Activity and Saccade-Related Activity -- 3.16.6 Integration of Multiple Information -- 3.16.7 Dynamic Changes of Functional Interactions Among Prefrontal Neurons -- 3.17 Delay-Period Activity Observed in Other Brain Areas -- 3.17.1 Frontal Eye Field -- 3.17.2 Orbitofrontal Cortex -- 3.17.3 Parietal Cortex -- 3.17.4 Inferior Temporal Cortex -- 3.17.5 Other Cortical Areas -- 3.17.6 Thalamus -- 3.17.7 Basal Ganglia -- 3.17.8 Other Subcortical Areas -- 3.18 Delay-Period Activity Is a Neural Mechanism for Temporarily Maintaining Information -- References -- Chapter 4: Executive Control -- 4.1 Introduction -- 4.2 What Is Executive Control? -- 4.3 Executive Control and the Prefrontal Cortex -- 4.3.1 Wisconsin Card Sorting Test -- 4.3.2 Tower of London Test -- 4.3.3 Self-Ordered Test -- 4.3.4 Other Tests Sensitive to Prefrontal Functions -- 4.3.5 Prefrontal Contribution to Executive Control -- 4.4 Executive Control by the Prefrontal Cortex -- 4.4.1 Control of Attention -- 4.4.1.1 Attention-Related Activity Observed in the Prefrontal Cortex -- 4.4.1.2 Attention-Related Activity in the Frontal Eye Field -- 4.4.1.3 Top-Down Control of Visual Information Processing by the Frontal Eye Field. 327 $a4.4.1.4 Top-Down Control of Visual Information Processing by the Prefrontal Cortex -- 4.4.2 Inhibitory Control -- 4.4.2.1 Anti-Saccade Task -- 4.4.2.2 Stop-Signal Paradigm -- 4.4.2.3 No-Go Dominant Activity -- 4.4.2.4 Conflict Conditions -- 4.4.3 Task Management -- 4.4.4 Shifting Stimulus or Action Categories -- 4.4.5 Planning -- 4.5 How Does the Prefrontal Cortex Achieve Executive Control? -- 4.6 Interactions between the Prefrontal Cortex and Other Cortical Areas -- 4.7 Conclusions -- References -- Chapter 5: Sensory and Motor Processing -- 5.1 Sensory Processing -- 5.1.1 Visual Processing -- 5.1.1.1 Characteristics of Visual Responses -- 5.1.1.2 Topographic Representation of Visual Response Features -- 5.1.1.3 Cue-Period Activity Observed During Performance of Cognitive Tasks -- 5.1.1.3.1 Visual Responses Observed During Delayed-Response Performances -- 5.1.1.3.2 Visual Responses in the ODR Task -- 5.1.1.3.3 Visual Responses in Matching-to-Sample Tasks and Discrimination Tasks -- 5.1.1.4 Discrimination of Relevant Visual Stimuli from Irrelevant Ones -- 5.1.1.5 Behavioral Context-Dependent Visual Responses -- 5.1.2 Auditory Processing -- 5.1.2.1 Auditory Projections to the Prefrontal Cortex -- 5.1.2.2 Auditory Responses in the Prefrontal Cortex -- 5.1.2.3 Selectivity of Auditory Responses and Participation in Vocal Communication -- 5.1.3 Somatosensory Processing -- 5.2 Skeletomotor Control -- 5.2.1 Anatomical Connections Between the Prefrontal Cortex and Cortical Motor Areas -- 5.2.2 Movement-Related Activity in the Prefrontal Cortex -- 5.2.3 Response-Period Activity Is Context Dependent -- 5.3 Eye Movement Control -- 5.3.1 Historical Perspective on the Prefrontal Contribution to Eye Movement Control -- 5.3.1.1 Effects of Electrical Stimulation in the Frontal Lobe -- 5.3.1.2 Saccade-Related Single-Neuron Activity in the Frontal Eye Field. 327 $a5.3.2 Saccade-Related Activity in the Dorsolateral Prefrontal Cortex. 410 0$aBrain Science 606 $aExecutive functions (Neuropsychology) 606 $aExecutive functions (Neuropsychology)$xResearch 615 0$aExecutive functions (Neuropsychology) 615 0$aExecutive functions (Neuropsychology)$xResearch. 676 $a153.733 700 $aFunahashi$b S$g(Shintaro),$01350646 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910635383403321 996 $aDorsolateral prefrontal cortex$93089307 997 $aUNINA