LEADER 02608nam 2200421 450 001 9910634041203321 005 20230419092456.0 010 $a3-031-10691-1 035 $a(MiAaPQ)EBC7156901 035 $a(Au-PeEL)EBL7156901 035 $a(CKB)25703760400041 035 $a(EXLCZ)9925703760400041 100 $a20230419d2022 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDiscovery DMPK quick guide $eguide to data interpretation and integration /$fS. Cyrus Khojasteh [and three others] 210 1$aCham, Switzerland :$cSpringer International Publishing,$d[2022] 210 4$dİ2022 215 $a1 online resource (241 pages) 311 08$aPrint version: Khojasteh, S. Cyrus Discovery DMPK Quick Guide Cham : Springer International Publishing AG,c2023 9783031106903 327 $aGoals for DMPK during drug optimizations -- Drug Properties -- DMPK in lead optimization -- Candidate translational characterization -- Q&A of DMPK issues and tools for drug discovery -- ADME assays -- Regulatory documents for IND to Support FIH -- Appendix: Chemical nomenclature. 330 $aThis book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions. 606 $aDrug development 606 $aDrugs$xDesign 615 0$aDrug development. 615 0$aDrugs$xDesign. 676 $a615.19 702 $aKhojasteh$b S. Cyrus 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910634041203321 996 $aDiscovery DMPK quick guide$93089829 997 $aUNINA