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010   $a9789811971228$b(electronic bk.)
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024 7 $a10.1007/978-981-19-7122-8
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035   $a(DE-He213)978-981-19-7122-8
035   $a(OCoLC)1356575649
035   $a(EXLCZ)9925616804100041
100   $a20221208d2022      u|         0
101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aBiology of Vascular Smooth Muscle $eVasoconstriction and Dilatation /$fby Yuansheng Gao
205   $a2nd ed. 2022.
210  1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2022.
215   $a1 online resource (422 pages)
225 1 $aBiomedical and Life Sciences Series
311 08$aPrint version: Gao, Yuansheng Biology of Vascular Smooth Muscle Singapore : Springer,c2023 9789811971211 
327   $aArchitecture of the vessel wall -- Ultrastructure of vascular smooth muscle -- Vascular endothelium -- Electrical and mechanical properties of vascular smooth muscle -- Biochemistry of the contractile proteins of smooth muscle -- Metabolism of vascular smooth muscle -- Neurotransmitters -- Endothelium-derived factors -- Local metabolic factors -- Shear stress, myogenic response, and blood flow autoregulation -- Intracellular Ca2+ regulation -- Regulation of myosin light chain phosphorylation -- Cyclic AMP signaling -- Cyclic GMP signaling -- MicroRNAs and vasoreactivity -- Extracellular vesicles as unique signaling messengers -- Genetic and epigenetic modification -- Coronary vasoreactivity -- Cerebral vasoreactivity -- Pulmonary vasoreactivity -- Renal vasoreactivity -- Hypoxic vasoreactivity  -- Ageing and vasoreactivity.
330   $aThis book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.
410  0$aBiomedical and Life Sciences Series
606   $aHuman physiology
606   $aPhysiology
606   $aInternal medicine
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aHuman Physiology
606   $aPhysiology
606   $aInternal Medicine
606   $aBiomedical Research
615  0$aHuman physiology.
615  0$aPhysiology.
615  0$aInternal medicine.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615 14$aHuman Physiology.
615 24$aPhysiology.
615 24$aInternal Medicine.
615 24$aBiomedical Research.
676   $a599.0116
700   $aGao$b Yuansheng$0989761
801  0$bMiAaPQ
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912   $a9910634037703321
996   $aBiology of Vascular Smooth Muscle$92996350
997   $aUNINA