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101 0 $aeng
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181   $ctxt$2rdacontent
182   $cc$2rdamedia
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200 10$aEstrogen as a Contributing Factor to the Development of Lipedema /$fwritten by Sara Al-Ghadban, Mary L. Teeler and Bruce A. Bunnell
210  1$aLondon :$cIntechOpen,$d2021.
215   $a1 online resource (136 pages)
311   $a1-83969-107-7 
327   $a1. Introduction -- 2. Estrogens and estrogen receptors in lipedema -- 2.1 Estrogen and adipogenesis -- 2.2 Estrogen and inflammation -- 3. Potential hormonal therapy -- 4. Conclusion -- Acknowledgments -- Conflict of interest -- References.
330   $aLipedema is an underdiagnosed painful adipose tissue disorder that occurs almost exclusively in women, with onset manifesting at puberty or at times of hormonal change. Unlike many fat disorders, diet and exercise have little to no impact on the prevention or progression of this disease. Estrogens control the distribution of body fat and food intake, regulate leptin expression, increase insulin sensitivity, and reduce inflammation through signaling pathways mediated by its receptors, estrogen receptor alpha (ER?) and ER?. This review will focus on understanding the role of estrogen in the pathogenesis of the disease and envisage potential hormonal therapy for lipedema patients.
606   $aEstrogen
615  0$aEstrogen.
676   $a573.44
700   $aAl-Ghadban$b Sara$01348886
702   $aBunnell$b Bruce A.
702   $aTeeler$b Mary L.
801  0$bNjHacI
801  1$bNjHacl
906   $aBOOK
912   $a9910633982303321
996   $aEstrogen as a Contributing Factor to the Development of Lipedema$93086577
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