LEADER 02281nam 2200373 450 001 9910633968403321 005 20230326180656.0 010 $a1-80355-622-6 035 $a(CKB)5700000000338677 035 $a(NjHacI)995700000000338677 035 $a(EXLCZ)995700000000338677 100 $a20230326d2022 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aGene Expression $eedited by Fumiaki Uchiumi 210 1$aLondon :$cIntechOpen,$d[2022] 210 4$dİ2022 215 $a1 online resource (216 pages) 311 $a1-80355-621-8 327 $a1. Introductory Chapter: Gene Expression in Eukaryotic Cells. 2. Transcription Elongation Factors in Health and Disease. 3. Biophysical and Biochemical Approaches for R-Loop Sensing Mechanism. 4. lncRNAs: Role in Regulation of Gene Expression. 5. Gene Expression and Transcriptome Sequencing: Basics, Analysis, Advances. 6. APC and MSH2 mRNA Quantitative Gene Expression and Bayesian Analysis of Proband in Hereditary Colorectal Carcinoma. 7. Circular DNA: How Circular DNA Assists Cancer Roll with Therapeutic Punches. 8. Genetics of Colorectal Cancer Racial Disparities. 9. Bayesian Random-Effects Meta-Analysis Models in Gene Expression Studies. 330 $aGene expression is dependent on multiple steps, including transcription, RNA processing, and translation. Importantly, recent studies revealed that gene expression is regulated by chromatin structures and non-coding RNA profiles. Elucidating the molecular mechanisms may contribute to the development of novel therapeutics for aging-related diseases, including cancer and neurodegenerative diseases. This book provides a comprehensive overview of gene expression and its role in human disease. It consists of nine chapters organized into two sections on molecular mechanisms in controlling gene expression and the relationships between transcriptional control and human disease. 606 $aGene expression 615 0$aGene expression. 676 $a572.865 702 $aUchiumi$b Fumiaki 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910633968403321 996 $aGene expression$9795582 997 $aUNINA