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010   $a3-031-18629-X
024 7 $a10.1007/978-3-031-18629-5
035   $a(MiAaPQ)EBC7147184
035   $a(Au-PeEL)EBL7147184
035   $a(CKB)25483505900041
035   $a(PPN)266349560
035   $a(OCoLC)1353296907
035   $a(DE-He213)978-3-031-18629-5
035   $a(EXLCZ)9925483505900041
100   $a20221125d2022      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDNA-Encoded Libraries /$fedited by Andreas Brunschweiger, Damian W. Young
205   $a1st ed. 2022.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022.
215   $a1 online resource (280 pages)
225 1 $aTopics in Medicinal Chemistry,$x1862-247X ;$v40
311 08$aPrint version: Brunschweiger, Andreas DNA-Encoded Libraries Cham : Springer International Publishing AG,c2022 9783031186288 
320   $aIncludes bibliographical references.
327   $aA History of Selection-Based High-Throughput Screening Technologies for Hit Identification -- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical Libraries -- Advancements in DEL-Compatible Chemical Reactions -- Design Considerations in Constructing and Screening DNA-Encoded Libraries -- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries -- Selection Strategies in DNA-Encoded Libraries -- From DEL Selections to Validated Hits to Clinical Leads -- A Perspective on 30 Years of DNA-Encoded Chemistry. .
330   $aThis book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening(HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery. The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as graduate students and scholars who are interested in this rapidly improving technology.
410  0$aTopics in Medicinal Chemistry,$x1862-247X ;$v40
606   $aPharmaceutical chemistry
606   $aPhysical biochemistry
606   $aBiology$xTechnique
606   $aBiophysics
606   $aProteins
606   $aMedicinal Chemistry
606   $aBiophysical Chemistry
606   $aBiophysical Methods
606   $aProtein Biochemistry
615  0$aPharmaceutical chemistry.
615  0$aPhysical biochemistry.
615  0$aBiology$xTechnique.
615  0$aBiophysics.
615  0$aProteins.
615 14$aMedicinal Chemistry.
615 24$aBiophysical Chemistry.
615 24$aBiophysical Methods.
615 24$aProtein Biochemistry.
676   $a929.605
676   $a615.19
702   $aBrunschweiger$b Andreas
702   $aYoung$b Damian W.
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910632474303321
996   $aDNA-Encoded Libraries$92982337
997   $aUNINA