LEADER 04518nam 2200553 450 001 9910632469203321 005 20231027175903.0 010 $a3-030-89937-3 035 $a(MiAaPQ)EBC7145544 035 $a(Au-PeEL)EBL7145544 035 $a(CKB)25456393000041 035 $a(PPN)266353576 035 $a(EXLCZ)9925456393000041 100 $a20230407d2023 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMosaicism in human skin $eunderstanding nevi, nevoid skin disorders, and cutaneous neoplasia /$fRudolf Happle, Antonio Torrelo 205 $aSecond edition. 210 1$aCham, Switzerland :$cSpringer,$d[2023] 210 4$dİ2023 215 $a1 online resource (251 pages) $cillustrations, portrait 311 08$aPrint version: Happle, Rudolf Mosaicism in Human Skin Cham : Springer International Publishing AG,c2022 9783030899363 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Preface -- Acknowledgments -- 1: Introduction -- 2: Mosaicism as a Biological Concept -- 2.1 Historical Beginnings -- 2.2 Mosaicism in Plants -- 2.3 Mosaicism in Animals -- 2.4 Mosaicism in Human Skin -- 2.5 Mosaicism Versus Chimerism -- 2.6 Does the Coat of Zebras Reflect Mosaicism? -- References -- 3: The Major Categories of Mosaicism -- 3.1 Nonsegmental Versus Segmental Mosaicism of Autosomal Dominant Skin Disorders -- 3.1.1 Nonsegmental Mosaicism -- 3.1.2 Segmental Mosaicism -- 3.2 Genomic Versus Epigenetic Mosaicism -- 3.3 Genomic Mosaicism -- 3.3.1 Genomic Mosaicism of Autosomes -- 3.3.1.1 Mosaicism Caused by Loss of Heterozygosity -- 3.3.1.2 Genomic Mosaicism of Lethal Autosomal Mutations -- Mosaicism Caused by Lethal Cytogenetic Abnormalities -- Mosaicism Caused by Lethal Molecular Defects -- 3.3.1.3 Genomic Mosaicism of Nonlethal Autosomal Mutations -- Simple Segmental Mosaicism of Autosomal Dominant Disorders -- Superimposed Mosaicism of Autosomal Dominant Disorders -- Monoallelic Versus Biallelic Mosaicism -- Disseminated Mosaicism of Biallelic Autosomal Dominant Disorders -- Isolated Segmental Biallelic Monoclonal Mosaicism -- Blue Rubber Bleb Angiomatosis ("Blue Rubber Bleb Nevus Syndrome"): A Unique Type of Postzygotic Mosaicism -- 3.3.2 Autosomal Recessive Mosaicism -- 3.3.3 Didymosis (Twin Spotting) -- 3.3.4 Revertant Mosaicism -- 3.3.5 Genomic X-Chromosome Mosaicism in Male Patients -- 3.3.6 Superimposed Segmental Manifestation of Polygenic Skin Disorders -- 3.4 Epigenetic Mosaicism -- 3.4.1 Epigenetic Mosaicism of Autosomal Genes -- 3.4.2 Epigenetic Mosaicism of X Chromosomes -- 3.4.2.1 Functional X-Chromosome Mosaicism in Female Patients -- 3.4.2.2 Why Do Women Live Longer? -- 3.4.2.3 Functional X-Chromosome Mosaicism in Male Patients -- 3.4.3 X-Linked Genes Escaping Inactivation -- References -- 4: Relationship Between Hypomorphic Alleles and Mosaicism of X-Linked or Autosomal Mutations -- 4.1 Hypomorphic Alleles and X-Linked Dominant, Male-Lethal Cutaneous Syndromes -- 4.2 Hypomorphic Alleles in Autosomal Dominant Skin Disorders -- References -- 5: The Archetypical Patterns of Segmental Cutaneous Mosaicism -- 5.1 Lines of Blaschko -- 5.1.1 Lines of Blaschko, Narrow Bands -- 5.1.2 Lines of Blaschko, Broad Bands -- 5.1.3 Analogy of Blaschko's Lines in Other Organs -- 5.1.4 Blaschko's Lines in Animals -- 5.1.5 Analogy of Blaschko's Lines in the Murine Brain -- 5.2 Flag-like Pattern -- 5.3 Phylloid Pattern -- 5.4 Lateralization Pattern -- References -- 6: Less Well-Defined or So Far Unclassifiable Patterns -- 6.1 Oblique Pattern (Sash-Like Pattern) -- 6.2 Pallister-Killian Pattern -- 6.3 Midfacial Pattern -- References -- 7: Nevi -- 7.1 The Theory of Lethal Genes Surviving by Mosaicism -- 7.2 Pigmentary Nevi -- 7.2.1 Melanocytic Nevi -- 7.2.1.1 Common Small Melanocytic Nevus. 606 $aSkin$xDiseases 606 $aMosaicism 606 $aSkin Neoplasms 606 $aSkin Diseases 606 $aNevus 606 $aMosaicism 615 0$aSkin$xDiseases. 615 0$aMosaicism. 615 12$aSkin Neoplasms. 615 22$aSkin Diseases. 615 22$aNevus. 615 22$aMosaicism. 676 $a616.5 700 $aHapple$b R$g(Rudolf),$0755408 702 $aTorrelo$b Antonio 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910632469203321 996 $aMosaicism in Human Skin$92982867 997 $aUNINA LEADER 04425nam 22007334a 450 001 9910781907703321 005 20230617042022.0 010 $a1-282-19400-3 010 $a9786612194009 010 $a3-11-019763-4 024 7 $a10.1515/9783110197631 035 $a(CKB)1000000000520857 035 $a(EBL)325606 035 $a(OCoLC)191926189 035 $a(SSID)ssj0000250528 035 $a(PQKBManifestationID)11204041 035 $a(PQKBTitleCode)TC0000250528 035 $a(PQKBWorkID)10232041 035 $a(PQKB)11486669 035 $a(MiAaPQ)EBC325606 035 $a(DE-B1597)32234 035 $a(OCoLC)979583537 035 $a(DE-B1597)9783110197631 035 $a(Au-PeEL)EBL325606 035 $a(CaPaEBR)ebr10197184 035 $a(CaONFJC)MIL219400 035 $a(OCoLC)191818361 035 $a(EXLCZ)991000000000520857 100 $a20051102d2005 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStandard negation$b[electronic resource] $ethe negation of declarative verbal main clauses in a typological perspective /$fby Matti Miestamo 210 $aBerlin ;$aNew York $cMouton de Gruyter$dc2005 215 $a1 online resource (504 p.) 225 1 $aEmpirical approaches to language typology ;$v31 300 $aDescription based upon print version of record. 311 0 $a3-11-018579-2 320 $aIncludes bibliographical references (p. [412]-469) and indexes. 327 $tFront matter --$tContents --$tChapter 1 Introduction --$tChapter 2 Theoretical and methodological issues --$tChapter 3 Classification --$tChapter 4 Quantitative data --$tChapter 5 Functional motivations --$tChapter 6 Conclusions --$tBack matter 330 $aThis book is the first cross-linguistic study of clausal negation based on an extensive and systematic language sample. Methodological issues, especially sampling, are discussed at length. Standard negation - the basic structural means languages have for negating declarative verbal main clauses - is typologized from a new perspective, paying attention to structural differences between affirmatives and negatives. In symmetric negation affirmative and negative structures show no differences except for the presence of the negative marker(s), whereas in asymmetric negation there are further structural differences, i.e. asymmetries. A distinction is made between constructional and paradigmatic asymmetry; in the former the addition of the negative marker(s) is accompanied by further structural differences in comparison to the corresponding affirmative, and in the latter the correspondences between the members of (verbal etc.) paradigms used in affirmatives and negatives are not one-to-one. Cross-cutting the constructional-paradigmatic distinction, asymmetric negation can be further divided into subtypes according to the nature of the asymmetry. Standard negation structures found in the 297 sample languages are exemplified and discussed in detail. The frequencies of the different types and some typological correlations are also examined. Functional motivations are proposed for the structural types - symmetric negatives are language-internally analogous to the linguistic structure of the affirmative and asymmetric negatives are language-externally analogous to different asymmetries between affirmation and negation on the functional level. Relevant diachronic issues are also discussed. The book is of interest to language typologists, descriptive linguists and to all linguists interested in negation. 410 0$aEmpirical approaches to language typology ;$v31. 606 $aGrammar, Comparative and general$xNegatives 606 $aGrammar, Comparative and general$xClauses 606 $aGrammar, Comparative and general$xVerb 606 $aTypology (Linguistics) 610 $aLanguage Typology. 610 $aNegation. 615 0$aGrammar, Comparative and general$xNegatives. 615 0$aGrammar, Comparative and general$xClauses. 615 0$aGrammar, Comparative and general$xVerb. 615 0$aTypology (Linguistics) 676 $a415 686 $aET 740$2rvk 700 $aMiestamo$b Matti$f1972-$01547600 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910781907703321 996 $aStandard negation$93820330 997 $aUNINA