LEADER 01053nam0-22003371i-450- 001 990008091310403321 005 20140415141231.0 010 $a88-076-0081-1 035 $a000809131 035 $aFED01000809131 035 $a(Aleph)000809131FED01 035 $a000809131 100 $a20050418d1991----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aSchizofrenia e guarigione$epsichiatria ed economia politica$fRichard Warner$gprefazione di Michele Tansella$gintroduzione e cura di Giovanni de Girolamo 210 $aMilano$cFeltrinelli$d1991 215 $a494 p.$d23 cm 225 1 $aBiblioteca di psichiatria e di psicologia clinica$v81 676 $a616.8982$v20$zita 700 1$aWarner,$bRichard$f<1943- >$0329546 702 1$aTansella,$bMichele 702 1$aDe Girolamo,$bGiovanni 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990008091310403321 952 $aXI G W 19$b2000$fDFD 959 $aDFD 996 $aSchizofrenia e guarigione$9753169 997 $aUNINA LEADER 03177nam 2200613Ia 450 001 9910144402103321 005 20170815112402.0 010 $a1-282-34275-4 010 $a9786612342752 010 $a0-470-72155-3 010 $a0-470-72156-1 035 $a(CKB)1000000000579667 035 $a(EBL)406495 035 $a(OCoLC)476225856 035 $a(SSID)ssj0000157792 035 $a(PQKBManifestationID)11155896 035 $a(PQKBTitleCode)TC0000157792 035 $a(PQKBWorkID)10144410 035 $a(PQKB)11411790 035 $a(MiAaPQ)EBC406495 035 $a(EXLCZ)991000000000579667 100 $a20080707d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFragment-based drug discovery$b[electronic resource] $ea practical approach /$feditors, Edward R. Zartler, Michael J. Shapiro 210 $aChichester, U.K. $cJohn Wiley & Sons$d2008 215 $a1 online resource (297 p.) 300 $aDescription based upon print version of record. 311 $a0-470-05813-7 320 $aIncludes bibliographical references and index. 327 $aFragment-Based Drug Discovery; Contents; List of Contributors; 1 Introduction to Fragment-based Drug Discovery; 2 Designing a Fragment Process to Fit Your Needs; 3 Assembling a Fragment Library; 4 Practical Aspects of Using NMR in Fragment-based Screening; 5 Application of Protein-Ligand NOE Matching to the Rapid Evaluation of Fragment Binding Poses; 6 Target-immobilized NMR Screening: Validation and Extension to Membrane Proteins; 7 In Situ Fragment-based Medicinal Chemistry: Screening by Mass Spectrometry; 8 Computational Approaches to Fragment and Substructure Discovery and Evaluation 327 $a9 Virtual Fragment Scanning: Current Trends, Applications and Web-based Tools10 Capture Methods for Fragment-based Discovery; 11 Identification of High-affinity -Secretase Inhibitors Using Fragment-based Lead Generation; Index 330 $aFragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical ti 606 $aDrug development 606 $aDrugs$xDesign 606 $aLigands (Biochemistry) 608 $aElectronic books. 615 0$aDrug development. 615 0$aDrugs$xDesign. 615 0$aLigands (Biochemistry) 676 $a615.19 676 $a615/.19 701 $aZartler$b Edward$0924230 701 $aShapiro$b Michael$g(Michael J.)$067246 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910144402103321 996 $aFragment-based drug discovery$92074092 997 $aUNINA LEADER 03773nam 2200625 c 450 001 9910629584103321 005 20240308190956.0 010 $a0-19-268965-7 010 $a0-19-195649-X 010 $a0-19-268964-9 024 7 $a10.1093/oso/9780192865748.001.0001 035 $a(MiAaPQ)EBC7075544 035 $a(Au-PeEL)EBL7075544 035 $a(CKB)24717065700041 035 $a(UK-OxUP)9780191956492 035 $a(PPN)268195609 035 $a(EXLCZ)9924717065700041 100 $a20220510d2022|||| ||| | 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSick note $ea history of the British welfare state /$fGareth Millward 210 1$aOxford :$cOxford University Press,$d[2022] 215 $a1 online resource (245 pages) 225 1 $aOxford scholarship online. 311 $a0-19-286574-9 320 $aIncludes bibliographical references and index. 327 $aList of Figures -- List of Abbreviations -- 1. Introduction -- 2. The 'Birth' of the Sick Note -- 3. Absenteeism and Postwar Rebuilding -- 4. Chauvinists and Breadwinners in the 'Classic Welfare State' -- 5. Privatization? The Sick Note into the 1980s -- 6. Chronicity and Capacity towards the New Millennium -- 7. The 'Death' of the Sick Note? -- 8. Conclusion -- Bibliography -- Index. 330 3 $aSick Note is a history of how the British state asked, 'who is really sick?' Tracing medical certification for absence from work from 1948 to 2010, it shows that doctors, employers, employees, politicians, media commentators, and citizens each concerned themselves with measuring sickness. At various times, each understood that a signed note from a doctor was not enough to 'prove' whether someone was 'really' sick. Yet, with no better alternative on offer, the sick note survived in practice and in the popular imagination-just like the welfare state itself. Sick Note reveals the interplay between medical, employment, and social security policy. The physical note became an integral part of working and living in Britain, while the term 'sick note' was often deployed rhetorically as a mocking nickname or symbol of Britain's economic and political troubles. Using government policy documents, popular media, internet archives, and contemporary research, this book covers the evolution of medical certification and the welfare state since the Second World War, demonstrating how sickness and disability policies responded to demographic and economic changes-though not always satisfactorily for administrators or claimants. Moreover, despite the creation of 'the fit note' in 2010, the idea of 'the sick note' has remained. With the specific challenges posed by the global pandemic in the early 2020s, Sick Note shows how the question of 'who is really sick?' has never been straightforward and will continue to perplex the British state. 410 0$aOxford Academic. 517 $aSick Note 606 $aWelfare state 606 $aSocial Welfare$xhistory 606 $aWelfare state$xHistory 606 $aSick leave 606 $aSocial medicine$zGreat Britain 606 $aSick leave$xSocial aspects$zGreat Britain 606 $aSick leave$xEconomic aspects$zGreat Britain 615 0$aWelfare state. 615 0$aSocial Welfare$xhistory. 615 0$aWelfare state$xHistory. 615 0$aSick leave. 615 0$aSocial medicine 615 0$aSick leave$xSocial aspects 615 0$aSick leave$xEconomic aspects 676 $a305.5620942 700 $aMillward$b Gareth$0880261 801 0$bUK-OxUP 801 1$bUK-OxUP 906 $aBOOK 912 $a9910629584103321 996 $aSick Note$92966053 997 $aUNINA