LEADER 07336nam 22009015 450 001 9910629284303321 005 20240426132239.0 010 $a3-031-06573-5 024 7 $a10.1007/978-3-031-06573-6 035 $a(MiAaPQ)EBC7133716 035 $a(Au-PeEL)EBL7133716 035 $a(CKB)25299356500041 035 $a(OCoLC)1350689371 035 $a(DE-He213)978-3-031-06573-6 035 $a(PPN)266348971 035 $a(EXLCZ)9925299356500041 100 $a20221108d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNuclear, Chromosomal, and Genomic Architecture in Biology and Medicine /$fedited by Malgorzata Kloc, Jacek Z. Kubiak 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (657 pages) 225 1 $aResults and Problems in Cell Differentiation,$x1861-0412 ;$v70 311 08$aPrint version: Kloc, Malgorzata Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine Cham : Springer International Publishing AG,c2022 9783031065729 320 $aIncludes bibliographical references. 327 $aPart I. Genome Architecture, Evolution, and Cell Fate -- Chapter 1. Networks and Islands of Genome Nano-Architecture and their Potential Relevance for Radiation Biology (A Hypothesis and Experimental Verification Hints) -- Chapter 2. A Unified Genomic Mechanism of Cell-Fate Change -- Chapter 3. Alterations to Genome Organisation in Stem Cells, Their Differentiation and Associated Diseases -- Chapter 4. How Genomes Emerge, Function, and Evolve: Living Systems Emergence - Genotype-Phenotype-Multilism - Genome/Systems Ecology -- Chapter 5. Integrating Multimorbidity into a Whole-Body Understanding of Disease Using Spatial Genomics -- Part II. Chromosomes and Chromatin Architecture and Dynamics -- Chapter 6. Mitotic Antipairing of Homologous Chromosomes -- Chapter 7. CENP-A, a Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States -- Chapter 8. Scaling Relationship in Chromatin as a Polymer -- Chapter 9. Chromatin Dynamics during Entry to Quiescence and Compromised Functionality in Cancer Cells -- Chapter 10. Functional Aspects of Sperm Chromatin Organization -- Part III. Mechanosensitive and Epigenetic Regulators of Gene Expression and Chromatin Organization -- Chapter 11. The LINC Complex Assists the Nuclear Import of Mechanosensitive Transcriptional Regulators -- Chapter 12. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype -- Chapter 13. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle -- Chapter 14. Histone Modifications in Mouse Pronuclei and Consequences for Embryo Development -- Part IV. Nucleus, Nucleolus, and Nucleolar Organizer Architecture -- Chapter 15. Nuclear Architecture in the Nervous System -- Chapter 16. Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms -- Chapter 17. Nuclear Organization in Response to Stress: A Special Focus on Nucleoli -- Chapter 18. Simulation of Different Three-Dimensional Models of Whole Interphase Nuclei Compared to Experiment ? A Consistent Scale-Bridging Simulation Framework for Genome Organization -- Chapter 19. Nucleolar Organizer Regions as Transcription-Based Scaffolds of Nucleolar Structure and Function -- Chapter 20. A Transient Mystery: Nucleolar Channel Systems -- Part V. Nuclear Actin Role in Polarization, Genome Organization, and Gene Expression -- Chapter 21. Cellular Polarity Transmission to the Nucleus -- Chapter 22. The Role of Nuclear Actin in Genome Organization and Gene Expression Regulation During Differentiation -- Chapter 23. Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer. 330 $aThis volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture. 410 0$aResults and Problems in Cell Differentiation,$x1861-0412 ;$v70 606 $aCell nuclei 606 $aChromosomes 606 $aBiology$xTechnique 606 $aGenomics 606 $aBiomaterials 606 $aNucleic acids 606 $aGene expression 606 $aNuclear Organization 606 $aChromosomes 606 $aGenomic Analysis 606 $aNucleic Acid 606 $aGene Expression Analysis 606 $aCitologia$2thub 606 $aCromosomes$2thub 606 $aGenòmica$2thub 606 $aNuclis cel·lulars$2thub 606 $aDiferenciació cel·lular$2thub 608 $aLlibres electrònics$2thub 615 0$aCell nuclei. 615 0$aChromosomes. 615 0$aBiology$xTechnique. 615 0$aGenomics. 615 0$aBiomaterials. 615 0$aNucleic acids. 615 0$aGene expression. 615 14$aNuclear Organization. 615 24$aChromosomes. 615 24$aGenomic Analysis. 615 24$aNucleic Acid. 615 24$aGene Expression Analysis. 615 7$aCitologia 615 7$aCromosomes 615 7$aGenòmica 615 7$aNuclis cel·lulars 615 7$aDiferenciació cel·lular 676 $a571.835 676 $a611.0181 702 $aKloc$b Malgorzata 702 $aKubiak$b Jacek Z. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910629284303321 996 $aNuclear, Chromosomal, and Genomic Architecture in Biology and Medicine$92967813 997 $aUNINA