LEADER 00851nam0 2200277 450 001 9910571301403321 005 20220613075321.0 010 $a9788832240658 100 $a20220613d2022----km y0itay50 ba 101 0 $aita 102 $aIT 105 $aa 001yy 200 1 $aA Roma. Immagini, figure e idea di una cittą$fa cura di Antonella Greco, Elisabetta Cristallini 210 $aPalermo$cEdizioni Caracol$d2022 215 $a463 p.$cill.$d25 cm 225 0 $aStoria dell'urbanistica$v13/2021 304 $aTitolo tratto dalla copertina 702 1$aGreco,$bAntonella 702 1$aCristallini,$bElisabetta 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910571301403321 952 $a12.1702$b49/22$fDARST 959 $aDARST 996 $aA Roma. Immagini, figure e idea di una cittą$92863549 997 $aUNINA LEADER 00888nam0-2200277 --450 001 9910628386903321 005 20221129095426.0 010 $a88-424-9899-8 100 $a20221129d2006----kmuy0itay5050 ba 101 0 $aita 102 $aIT 105 $a 001yy 200 1 $aDizionario del fascismo$estoria, personaggi, cultura, economia fonti e dibattito storiografico$fa cura di Alberto De Bernardi e Scipione Guarracino 210 $aMilano$cB. Mondadori$dstampa 2006 215 $aXXV, 625 p.$d19 cm 225 1 $aEconomica$v2 610 0 $aFascismo$aItalia$aEnciclopedie e dizionari 702 1$aGuarracino,$bScipione 702 1$aDe Bernardi,$bAlberto 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910628386903321 952 $aFONDO ROSSI 1450$bROSSI 1492$fFARBC 959 $aFARBC 996 $aDizionario del fascismo$9472668 997 $aUNINA LEADER 02058nam 2200337 450 001 9910674006303321 005 20230622221838.0 035 $a(CKB)4100000002047011 035 $a(NjHacI)994100000002047011 035 $a(EXLCZ)994100000002047011 100 $a20230622d2018 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular Entry of Binary and Pore-Forming Bacterial Toxins /$fAlexey S. Ladokhin 210 1$aBasel :$cMDPI AG - Multidisciplinary Digital Publishing Institute,$d2018. 215 $a1 online resource (128 pages) 311 $a3-03842-704-7 330 $aAnnotation Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues. 606 $aBacterial toxins 615 0$aBacterial toxins. 676 $a615.95299 700 $aLadokhin$b Alexey S.$01368098 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910674006303321 996 $aCellular Entry of Binary and Pore-Forming Bacterial Toxins$93392606 997 $aUNINA