LEADER 05058nam 2200601Ia 450 001 9910627299803321 005 20200520144314.0 010 $a1-283-42582-3 010 $a9786613425829 010 $a1-84593-901-8 035 $a(CKB)2670000000131543 035 $a(EBL)837628 035 $a(OCoLC)773565129 035 $a(SSID)ssj0000588671 035 $a(PQKBManifestationID)12264197 035 $a(PQKBTitleCode)TC0000588671 035 $a(PQKBWorkID)10663651 035 $a(PQKB)10847206 035 $a(MiAaPQ)EBC837628 035 $a(EXLCZ)992670000000131543 100 $a20110411d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAmino acids in human nutrition and health /$fedited by J.P.F. D'Mello 210 $aWallingford, Oxfordshire ;$aCambridge, MA $cCABI$dc2012 215 $a1 online resource (578 p.) 300 $aDescription based upon print version of record. 311 $a1-84593-798-8 320 $aIncludes bibliographical references and index. 327 $aContents; Contributors; Preface; Glossary; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; PART I: ENZYMES AND METABOLISM; 1 Glutamate Dehydrogenase; 1.1 Abstract; 1.2 Introduction; 1.3 GDH in Animals; 1.4 Active Site; 1.5 Role of GDH in Insulin Homeostasis; 1.6 Evolution of GDH Allostery; 1.7 Conclusions; 1.8 Acknowledgements; 2 Aminotransferases; 2.1 Abstract; 2.2 Introduction; 2.3 The Role of Aminotransferases in Brain Metabolism; 2.4 Alanine Aminotransferases and Glutamate 327 $a2.5 Aspartate Aminotransferases and their Role in the Malate-Aspartate Shuttle and Glutamate Metabolism2.6 Pathological Conditions Resulting from Impaired Aminotransferase Metabolism; 2.7 Aminotransferase Proteins as Biomarkers of Disease; 2.8 Conclusions and Future Directions; 3 Arginase; 3.1 Abstract; 3.2 Introduction; 3.3 Isoforms and Distribution; 3.4 Structure and Location of Arginase; 3.5 Involvement of Arginase in Health and Disease; 3.6 Regulation of Activity; 3.7 Arginase Inhibitors; 3.8 Conclusions 327 $a4 Bypassing the Endothelial L-Arginine-Nitric Oxide Pathway: Effects of Dietary Nitrite and Nitrate on Cardiovascular Function4.1 Abstract; 4.2 Introduction; 4.3 L-Arginine: A Semi-Essential Amino Acid in Human Physiology; 4.4 L-Arginine is the Substrate of the Nitric Oxide Synthases: The L-Arginine-Nitric Oxide Pathway; 4.5 L-Arginine in Cardiovascular Disease: Perspectives and Limitations; 4.6 Nitric Oxide Generation without NO-Synthase? Bypassing the L-Arginine Pathway; 4.7 The Nitrate-Nitrite-Nitric Oxide Pathway; 4.8 Effects of Nitrite and Nitrate in Human Physiology 327 $a4.9 Dietary Nitrate and Nitrite4.10 Conclusions; 4.11 Acknowledgements; 5 Histidine Decarboxylase; 5.1 Abstract; 5.2 Introduction; 5.3 Histidine Decarboxylase Enzyme; 5.4 Histidine Decarboxylase Gene; 5.5 Pharmacological Inhibition; 5.6 mRNA Antisense and Gene Knockout; 5.7 Neurophysiology and Behaviour; 5.8 Summary and Conclusions; 5.9 Acknowledgements; 6 Glutamate Decarboxylase; 6.1 Abstract; 6.2 Introduction; 6.3 Distribution of GABA; 6.4 GAD 65 in Blood Leucocytes; 6.5 Taste Signalling; 6.6 Suggestions for Future Research; 6.7 Conclusions; 6.8 Acknowledgements; 7 Glutaminase; 7.1 Abstract 327 $a7.2 Introduction7.3 Mammalian Glutaminase Genes and Transcripts; 7.4 Mammalian Glutaminase Enzymes; 7.5 Glutaminase Expression in Mammalian Brain; 7.6 State of Art and Perspectives; 7.7 Conclusions; 7.8 Acknowledgements; 8 D-Serine and Serine Racemase in the Retina; 8.1 Abstract; 8.2 Introduction; 8.3 NMDA Receptor and D-serine as a Co-agonist; 8.4 D-Serine in the Retina; 8.5 Mechanisms of D-Serine Uptake in the Retina; 8.6 D-Serine and Serine Racemase in Retinal Neurons; 8.7 Role of D-Serine in the Retina; 8.8 Role of D-Serine and Serine Racemase in Neuronal Cell Death; 8.9 Conclusions 327 $a8.10 Acknowledgements 330 $aHuman health issues relating to amino acids are extremely broad and include metabolic disorders of amino acid metabolism as well as their presence in food and use as supplements. This book covers the biochemistry of amino acid metabolism in the context of health and disease. It discusses their use as food supplements, in clinical therapy and nutritional support and focuses on major recent developments, highlighting new areas of research that will be needed to sustain further interest in the field. It is suitable researchers and students in human nutrition and food science. 606 $aAmino acids in human nutrition 606 $aAmino acids$xMetabolism 615 0$aAmino acids in human nutrition. 615 0$aAmino acids$xMetabolism. 676 $a612.015756 701 $aD'Mello$b J. P. Felix$01142273 712 02$aC.A.B. International. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910627299803321 996 $aAmino acids in human nutrition and health$92977124 997 $aUNINA