LEADER 04934nam 22006255 450 001 9910627240203321 005 20251008140702.0 010 $a3-031-12390-5 024 7 $a10.1007/978-3-031-12390-0 035 $a(MiAaPQ)EBC7119406 035 $a(Au-PeEL)EBL7119406 035 $a(CKB)25176341300041 035 $a(PPN)265857503 035 $a(DE-He213)978-3-031-12390-0 035 $a(OCoLC)1350428512 035 $a(EXLCZ)9925176341300041 100 $a20221018d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGlycobiology of the Nervous System /$fedited by Cara-Lynne Schengrund, Robert K. Yu 205 $a2nd ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (506 pages) 225 1 $aAdvances in Neurobiology,$x2190-5223 ;$v29 300 $aIncludes index. 311 08$aPrint version: Schengrund, Cara-Lynne Glycobiology of the Nervous System Cham : Springer International Publishing AG,c2022 9783031123894 327 $a1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates. -- 2. Introduction to cells comprising the nervous system. -- 3. Synthesis -- processing -- and function of N-glycans in N-glycoproteins. -- 4. Synthesis of O-linked glycoconjugates in the nervous system. -- 5. Chemistry and function of glycosaminoglycans in the nervous system. -- 6. Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system. -- 7. Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics. -- 8. Structural analysis of oligosaccharides and glycoconjugates using NMR. -- 9. Glycolipid and glycoprotein expression during neural development. -- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide). -- 11. Role of myelin-associated glycoproteins in the peripheral nervous system. -- 12. Glycosignaling: a general review. -- 13. Glycosphingolipids in the regulation of the nervous system. -- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration. -- 15. Glycoconjugates in nuclear membranes. -- 16. N-glycosylation in regulation of the nervous system. -- 17. Role of carbohydrates in the interaction of pathogens with neural cells. -- 18. Glycoconjugate changes in aging and age-related diseases. -- 19. Gangliosides and glycolipids in neurodegenerative disorders. -- 20. Inborn errors of glycosphingolipid catabolism and potential treatment. -- 21. Neurological aspects of human glycosylation disorders. -- 22. Glycoconjugates and neural tumors. -- 23. Galectins and neuroinflammation . -- 24. Glycoconjugates and neuroimmunological diseases. -- 25. Targeting nanoparticle drug carriers to the brain. -- 26. Use of quantum dots to treat inherited lysosomal storage diseases. -- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates. 330 $aThis new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators. 410 0$aAdvances in Neurobiology,$x2190-5223 ;$v29 606 $aNeurosciences 606 $aZoology 606 $aNeurochemistry 606 $aNeuroscience 606 $aZoology 606 $aNeurochemistry 615 0$aNeurosciences. 615 0$aZoology. 615 0$aNeurochemistry. 615 14$aNeuroscience. 615 24$aZoology. 615 24$aNeurochemistry. 676 $a572.567 676 $a612.8 702 $aSchengrund$b Cara-Lynne 702 $aYu$b Robert K. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910627240203321 996 $aGlycobiology of the Nervous System$92975430 997 $aUNINA