LEADER 05037nam 2200649 a 450 001 9910626114203321 005 20200520144314.0 010 $a1-283-67084-4 010 $a1-78064-031-5 035 $a(CKB)2670000000240871 035 $a(EBL)1044650 035 $a(OCoLC)813536564 035 $a(SSID)ssj0000757551 035 $a(PQKBManifestationID)12323569 035 $a(PQKBTitleCode)TC0000757551 035 $a(PQKBWorkID)10758942 035 $a(PQKB)11600417 035 $a(MiAaPQ)EBC1044650 035 $a(EXLCZ)992670000000240871 100 $a20120110d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAntimicrobial drug discovery $eemerging strategies /$fedited by George Tegos and Eleftherios Mylonakis 210 $aWallingford, Oxfordshire, U.K. $cCABI$d2012 215 $a1 online resource (369 p.) 225 0$aAdvances in molecular and cellular microbiology ;$v22 300 $aDescription based upon print version of record. 311 $a1-84593-943-3 320 $aIncludes bibliographical references and index. 327 $aEmerging discovery strategies : an evolving necessity / Anthony R. Ball and George P. Tegos -- The antibiotic crisis / Arnold L. Demain and Jaroslav Spizek -- Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of escerichia coli and salmonella / Leonard Amaral ... [et al.] -- Small molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents / Sanjay M. Jachak ... [et al.] -- Fungal efflux-mediated resistance : from targets to inhibitors / Brian C. Monk ... [et al.] -- Vacuolar ATPase (V-ATPase) : a model proton pump for antifungal drug discovery -- Karlett J Parra -- Drug tolerance, persister cells and drug discovery / Kim Lewis -- Inhibition of quorum sensing as a novel antimicrobial strategy -- Gilles Brackman, Hans J. Nelis and Tom Coenye -- Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target / Jaroslaw M. Boberek ... [et al.] -- Lysostaphin : a silver bullet for staph / John F. Kokai-Kun -- Strategies to identify modified ribosomally synthesized antimicrobials -- Alan J. Marsh ... [et al.] -- QSAR based discovery of antimicrobial peptides active against multidrug resistant bacteria / Christopher D. Fjell ... [et al.] -- Acetyl-CoA carboxylase as a target for antibacterial development / Grover L. Waldrop -- Underexploited targets in LPS biogenenesis for the design of antibacterials / Laura Cipolla ... [et al.] -- Predicting and dissecting biomolecular interactions by information-driven docking / Panagiotis Kastritsis & Alexandre M.J.J Bonvin -- Anti-fungals and anti-fungal drug discovery / Richard Calderone ... [et al.] -- Pathosystematic studies and the rational design of antifungal interventions / Elaine M Bignell and Darius Armstrong-James -- In vivo high-throughput antimicrobial discovery screens utilizing caenorhabditis elegans as an alternative host / Jeffrey J. Coleman and Eleftherios Mylonakis -- Drosophila melanogaster as a versatile model for discovery of drugs effective against human microbe-induced infection and pathology / Yiorgos Apidianakis and Dimitrios P. Kontoyiannis -- Antimicrobial photosensitizers - harnessing the power of light to treat infections / Sulbha K Sharma, Tianhong Dai and Michael R Hamblin -- Nanoparticle platforms for antimicrobial therapy / David Trofa, Joshua D. Nosanchuk -- Antimicrobial activity of carbon nanotubes / Shaobin Liu, Yuan Chen. 330 $aResistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vert 410 0$aAdvances in Molecular and Cellular Microbiology 606 $aAnti-infective agents 606 $aDrugs$xDesign 606 $aDiseases$xAnimal models 606 $aHigh throughput screening$xMethodology 606 $aPhotosensitizing compounds 606 $aPharmacology 615 0$aAnti-infective agents. 615 0$aDrugs$xDesign. 615 0$aDiseases$xAnimal models. 615 0$aHigh throughput screening$xMethodology. 615 0$aPhotosensitizing compounds. 615 0$aPharmacology. 676 $a615.7/92 701 $aTegos$b George$01267333 701 $aMylonakis$b Eleftherios$01267334 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910626114203321 996 $aAntimicrobial drug discovery$92980071 997 $aUNINA