LEADER 04736nam 22006255 450 001 9910624383203321 005 20251009103038.0 010 $a3-031-12398-0 024 7 $a10.1007/978-3-031-12398-6 035 $a(MiAaPQ)EBC7123183 035 $a(Au-PeEL)EBL7123183 035 $a(CKB)25201531200041 035 $a(PPN)265862795 035 $a(DE-He213)978-3-031-12398-6 035 $a(OCoLC)1349085628 035 $a(EXLCZ)9925201531200041 100 $a20221025d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRecent Advances in Therapeutic Drug Monitoring and Clinical Toxicology /$fedited by Seth Kwabena Amponsah, Yashwant V. Pathak 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (384 pages) 225 1 $aBiomedical and Life Sciences Series 311 08$aPrint version: Amponsah, Seth Kwabena Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Cham : Springer International Publishing AG,c2022 9783031123979 320 $aIncludes bibliographical references and index. 327 $aTherapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions. 330 $aThis book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges . 410 0$aBiomedical and Life Sciences Series 606 $aPharmacology 606 $aToxicology 606 $aPharmaceutical chemistry 606 $aPharmacology 606 $aToxicology 606 $aPharmaceutics 615 0$aPharmacology. 615 0$aToxicology. 615 0$aPharmaceutical chemistry. 615 14$aPharmacology. 615 24$aToxicology. 615 24$aPharmaceutics. 676 $a615.9 676 $a615.7 702 $aAmponsah$b Seth Kwabena 702 $aPathak$b Yashwant 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910624383203321 996 $aRecent advances in therapeutic drug monitoring and clinical toxicology$93060006 997 $aUNINA